The impact of the milk glycobiome on the neonate gut microbiota

Alline R. Pacheco, Daniela Barile, Mark Underwood, David A. Mills

Research output: Contribution to journalArticle

68 Citations (Scopus)

Abstract

Human milk is a complete source of nourishment for the infant. Exclusive breastfeeding not only sustains the infant's development but also guides the proliferation of a protective intestinal microbiota. Among the many components of milk that modulate the infant gut microbiota, the milk glycans, which comprise free oligosaccharides, glycoproteins, and glycolipids, are increasingly recognized as drivers of microbiota development and overall gut health. These glycans may display pleiotropic functions, conferring protection against infectious diseases and also acting as prebiotics, selecting for the growth of beneficial intestinal bacteria. The prebiotic effect of milk glycans has direct application to prevention of diseases such as necrotizing enterocolitis, a common and devastating disease of preterm infants. In this article, we review the impact of the human (and bovine) milk glycome on gut health through establishment of a milk-oriented microbiota in the neonate.

Original languageEnglish (US)
Pages (from-to)419-445
Number of pages27
JournalAnnual Review of Animal Biosciences
Volume3
DOIs
StatePublished - Feb 1 2015

Fingerprint

intestinal microorganisms
Milk
neonates
Newborn Infant
Polysaccharides
milk
Prebiotics
polysaccharides
Microbiota
Human Milk
prebiotics
breast milk
digestive system
infant development
enterocolitis
Necrotizing Enterocolitis
glycolipids
Glycolipids
breast feeding
disease prevention

Keywords

  • bifidobacteria
  • glycobiome
  • milk bioactives
  • milk oligosaccharides
  • neonatal microbiota

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)
  • Biotechnology
  • Genetics

Cite this

The impact of the milk glycobiome on the neonate gut microbiota. / Pacheco, Alline R.; Barile, Daniela; Underwood, Mark; Mills, David A.

In: Annual Review of Animal Biosciences, Vol. 3, 01.02.2015, p. 419-445.

Research output: Contribution to journalArticle

Pacheco, Alline R. ; Barile, Daniela ; Underwood, Mark ; Mills, David A. / The impact of the milk glycobiome on the neonate gut microbiota. In: Annual Review of Animal Biosciences. 2015 ; Vol. 3. pp. 419-445.
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