Abstract
Objective: Computed tomographyYbased treatment planning for cervical cancer has allowed investigation into the volumetric radiation dose delivered to the rectum. The goal of intracavitary brachytherapy is to maximize the tumor dose while decreasing the dose to normal tissue like the rectum. We investigated the effects of tandem angle and maximum rectal distention on rectal dose delivered in HDR brachytherapy for locally advanced cervical cancer. Materials and Methods: Between July 2007 and January 2010, 97 brachytherapy treatment planning computed tomographic scans from the first and last implant of 51 patients with locally advanced cervical cancer were reviewed. The rectum was manually contoured from the ischial tuberosity to the bottom of the sacroiliac joint. The maximum rectal distention was determined by measuring the largest anterior-posterior diameter of the rectum superior to the tandem ring and inferior to the end of the applicator. A volumetric measurement of the maximum and mean rectal dose, dose to 2 cc (D2cc), dose to 1cc (D1cc) of the rectum was calculated. The tandem angle and the Internal Commission on Radiation Units and Measurement rectal point were recorded, and a dose volume histogram was referenced. Results: The mean maximum rectal distention was 3.01 cm. The mean D1cc, D2cc, mean rectal dose, maximum rectal dose, and Internal Commission on Radiation Units and Measurement rectal dose were 3.03 Gy, 2.78 Gy, 4.19 cGy, 1.40 cGy, and 2.99 Gy per treatment, respectively. In a multivariate analysis controlling for surface area, tandem angle, and body mass index, there was a significant increase in D2cc with increasing rectal distention (P = 0.016). Therewere no significant findings when observing the effects of tandem angle on D2cc. Conclusion: Rectal distention significantly affects D2cc delivered in HDR brachytherapy. In contrast, tandem angle does not. Concerted efforts to decrease rectal distention should be considered during treatment planning and delivery.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1078-1083 |
| Number of pages | 6 |
| Journal | International Journal of Gynecological Cancer |
| Volume | 23 |
| Issue number | 6 |
| DOIs | |
| State | Published - Jul 2013 |
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Keywords
- Brachytherapy
- Cervical cancer
- CT
- Rectal distention
- Tandem angle
ASJC Scopus subject areas
- Obstetrics and Gynecology
- Oncology
Cite this
The impact of maximum rectal distention and tandem angle on rectal dose delivered in 3d planned gynecologic high doseyrate brachytherapy. / Lim, Jihoon; Durbin-Johnson, Blythe; Valicenti, Richard K; Mathai, Matthew; Stern, Robin L; Mayadev, Jyoti.
In: International Journal of Gynecological Cancer, Vol. 23, No. 6, 07.2013, p. 1078-1083.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The impact of maximum rectal distention and tandem angle on rectal dose delivered in 3d planned gynecologic high doseyrate brachytherapy
AU - Lim, Jihoon
AU - Durbin-Johnson, Blythe
AU - Valicenti, Richard K
AU - Mathai, Matthew
AU - Stern, Robin L
AU - Mayadev, Jyoti
PY - 2013/7
Y1 - 2013/7
N2 - Objective: Computed tomographyYbased treatment planning for cervical cancer has allowed investigation into the volumetric radiation dose delivered to the rectum. The goal of intracavitary brachytherapy is to maximize the tumor dose while decreasing the dose to normal tissue like the rectum. We investigated the effects of tandem angle and maximum rectal distention on rectal dose delivered in HDR brachytherapy for locally advanced cervical cancer. Materials and Methods: Between July 2007 and January 2010, 97 brachytherapy treatment planning computed tomographic scans from the first and last implant of 51 patients with locally advanced cervical cancer were reviewed. The rectum was manually contoured from the ischial tuberosity to the bottom of the sacroiliac joint. The maximum rectal distention was determined by measuring the largest anterior-posterior diameter of the rectum superior to the tandem ring and inferior to the end of the applicator. A volumetric measurement of the maximum and mean rectal dose, dose to 2 cc (D2cc), dose to 1cc (D1cc) of the rectum was calculated. The tandem angle and the Internal Commission on Radiation Units and Measurement rectal point were recorded, and a dose volume histogram was referenced. Results: The mean maximum rectal distention was 3.01 cm. The mean D1cc, D2cc, mean rectal dose, maximum rectal dose, and Internal Commission on Radiation Units and Measurement rectal dose were 3.03 Gy, 2.78 Gy, 4.19 cGy, 1.40 cGy, and 2.99 Gy per treatment, respectively. In a multivariate analysis controlling for surface area, tandem angle, and body mass index, there was a significant increase in D2cc with increasing rectal distention (P = 0.016). Therewere no significant findings when observing the effects of tandem angle on D2cc. Conclusion: Rectal distention significantly affects D2cc delivered in HDR brachytherapy. In contrast, tandem angle does not. Concerted efforts to decrease rectal distention should be considered during treatment planning and delivery.
AB - Objective: Computed tomographyYbased treatment planning for cervical cancer has allowed investigation into the volumetric radiation dose delivered to the rectum. The goal of intracavitary brachytherapy is to maximize the tumor dose while decreasing the dose to normal tissue like the rectum. We investigated the effects of tandem angle and maximum rectal distention on rectal dose delivered in HDR brachytherapy for locally advanced cervical cancer. Materials and Methods: Between July 2007 and January 2010, 97 brachytherapy treatment planning computed tomographic scans from the first and last implant of 51 patients with locally advanced cervical cancer were reviewed. The rectum was manually contoured from the ischial tuberosity to the bottom of the sacroiliac joint. The maximum rectal distention was determined by measuring the largest anterior-posterior diameter of the rectum superior to the tandem ring and inferior to the end of the applicator. A volumetric measurement of the maximum and mean rectal dose, dose to 2 cc (D2cc), dose to 1cc (D1cc) of the rectum was calculated. The tandem angle and the Internal Commission on Radiation Units and Measurement rectal point were recorded, and a dose volume histogram was referenced. Results: The mean maximum rectal distention was 3.01 cm. The mean D1cc, D2cc, mean rectal dose, maximum rectal dose, and Internal Commission on Radiation Units and Measurement rectal dose were 3.03 Gy, 2.78 Gy, 4.19 cGy, 1.40 cGy, and 2.99 Gy per treatment, respectively. In a multivariate analysis controlling for surface area, tandem angle, and body mass index, there was a significant increase in D2cc with increasing rectal distention (P = 0.016). Therewere no significant findings when observing the effects of tandem angle on D2cc. Conclusion: Rectal distention significantly affects D2cc delivered in HDR brachytherapy. In contrast, tandem angle does not. Concerted efforts to decrease rectal distention should be considered during treatment planning and delivery.
KW - Brachytherapy
KW - Cervical cancer
KW - CT
KW - Rectal distention
KW - Tandem angle
UR - http://www.scopus.com/inward/record.url?scp=84880314327&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84880314327&partnerID=8YFLogxK
U2 - 10.1097/IGC.0b013e3182959030
DO - 10.1097/IGC.0b013e3182959030
M3 - Article
C2 - 23792603
AN - SCOPUS:84880314327
VL - 23
SP - 1078
EP - 1083
JO - International Journal of Gynecological Cancer
JF - International Journal of Gynecological Cancer
SN - 1048-891X
IS - 6
ER -