Abstract
Methods: We compared the peripartum thromboelastographic profiles of healthy AMA women (age > 35 yr) and non-AMA women (age ≤ 35 yr) undergoing elective CD under neuraxial anesthesia. Blood samples were drawn prior to CD and at 24 hr and 72 hr post-CD. At each time point, we assessed thromboelastographic and other standard laboratory coagulation indices. We used a linear mixed-effects regression model (SAS® PROC MIXED) to assess between-group differences for individual thromboelastographic and laboratory coagulation parameters.
Results: The median [interquartile range] ages of women were 38 [37-41] yr and 29 [25-34] yr in the AMA and non-AMA groups, respectively (P <0.001). We observed no statistically significant effect of study group on any thromboelastographic or laboratory coagulation parameters. No statistically significant correlations were found between any thromboelastographic parameter and maternal age. Peripartum thromboelastography and coagulation profiles of healthy AMA and healthy non-AMA women up to 72 hr post-CD were also similar.
Purpose: Advanced maternal age (AMA) is a known risk factor for pregnancy-related venous thromboembolism. However, it is unclear if underlying differences exist in the maternal coagulation profiles of AMA vs non-AMA women. The aim of this prospective observational study was to compare peripartum thromboelastography parameters of AMA and non-AMA women undergoing elective Cesarean delivery (CD).
Conclusion: These data suggest that maternal thromboelastographic profiles of healthy AMA and non-AMA women undergoing elective CD are similar. The study was registered at ClinicalTrials.gov (identifier: NCT01416454).
| Original language | French |
|---|---|
| Pages (from-to) | 504-512 |
| Number of pages | 9 |
| Journal | Canadian Journal of Anesthesia |
| Volume | 62 |
| Issue number | 5 |
| DOIs | |
| State | Published - Apr 8 2015 |
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ASJC Scopus subject areas
- Anesthesiology and Pain Medicine
Cite this
Impact de l’âge maternel avancé sur les profils de coagulation thrombo-élastographique du péripatum : une étude observationnelle prospective exploratoire. / Butwick, Alexander; Gutierrez, Maria C; Hilton, Gillian.
In: Canadian Journal of Anesthesia, Vol. 62, No. 5, 08.04.2015, p. 504-512.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Impact de l’âge maternel avancé sur les profils de coagulation thrombo-élastographique du péripatum
T2 - une étude observationnelle prospective exploratoire
AU - Butwick, Alexander
AU - Gutierrez, Maria C
AU - Hilton, Gillian
PY - 2015/4/8
Y1 - 2015/4/8
N2 - Methods: We compared the peripartum thromboelastographic profiles of healthy AMA women (age > 35 yr) and non-AMA women (age ≤ 35 yr) undergoing elective CD under neuraxial anesthesia. Blood samples were drawn prior to CD and at 24 hr and 72 hr post-CD. At each time point, we assessed thromboelastographic and other standard laboratory coagulation indices. We used a linear mixed-effects regression model (SAS® PROC MIXED) to assess between-group differences for individual thromboelastographic and laboratory coagulation parameters.Results: The median [interquartile range] ages of women were 38 [37-41] yr and 29 [25-34] yr in the AMA and non-AMA groups, respectively (P <0.001). We observed no statistically significant effect of study group on any thromboelastographic or laboratory coagulation parameters. No statistically significant correlations were found between any thromboelastographic parameter and maternal age. Peripartum thromboelastography and coagulation profiles of healthy AMA and healthy non-AMA women up to 72 hr post-CD were also similar.Purpose: Advanced maternal age (AMA) is a known risk factor for pregnancy-related venous thromboembolism. However, it is unclear if underlying differences exist in the maternal coagulation profiles of AMA vs non-AMA women. The aim of this prospective observational study was to compare peripartum thromboelastography parameters of AMA and non-AMA women undergoing elective Cesarean delivery (CD).Conclusion: These data suggest that maternal thromboelastographic profiles of healthy AMA and non-AMA women undergoing elective CD are similar. The study was registered at ClinicalTrials.gov (identifier: NCT01416454).
AB - Methods: We compared the peripartum thromboelastographic profiles of healthy AMA women (age > 35 yr) and non-AMA women (age ≤ 35 yr) undergoing elective CD under neuraxial anesthesia. Blood samples were drawn prior to CD and at 24 hr and 72 hr post-CD. At each time point, we assessed thromboelastographic and other standard laboratory coagulation indices. We used a linear mixed-effects regression model (SAS® PROC MIXED) to assess between-group differences for individual thromboelastographic and laboratory coagulation parameters.Results: The median [interquartile range] ages of women were 38 [37-41] yr and 29 [25-34] yr in the AMA and non-AMA groups, respectively (P <0.001). We observed no statistically significant effect of study group on any thromboelastographic or laboratory coagulation parameters. No statistically significant correlations were found between any thromboelastographic parameter and maternal age. Peripartum thromboelastography and coagulation profiles of healthy AMA and healthy non-AMA women up to 72 hr post-CD were also similar.Purpose: Advanced maternal age (AMA) is a known risk factor for pregnancy-related venous thromboembolism. However, it is unclear if underlying differences exist in the maternal coagulation profiles of AMA vs non-AMA women. The aim of this prospective observational study was to compare peripartum thromboelastography parameters of AMA and non-AMA women undergoing elective Cesarean delivery (CD).Conclusion: These data suggest that maternal thromboelastographic profiles of healthy AMA and non-AMA women undergoing elective CD are similar. The study was registered at ClinicalTrials.gov (identifier: NCT01416454).
UR - http://www.scopus.com/inward/record.url?scp=84928229381&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84928229381&partnerID=8YFLogxK
U2 - 10.1007/s12630-014-0300-0
DO - 10.1007/s12630-014-0300-0
M3 - Article
C2 - 25549988
AN - SCOPUS:84928229381
VL - 62
SP - 504
EP - 512
JO - Canadian Journal of Anaesthesia
JF - Canadian Journal of Anaesthesia
SN - 0832-610X
IS - 5
ER -