Abstract
A prospective analysis of 38 cases of bovine lymphoma was performed. Thirty-five of the lymphomas were considered enzootic because of serologic or molecular biologic association with the bovine leukemia virus (BLV). The three remaining cases were in cattle < 1 year of age and were not associated with BLV and hence were considered sporadic lymphomas. Utilizing the National Cancer Institute Working Formulation for the morphologic classification of human non-Hodgkin's lymphoma, 54.3% (19/35) of the enzootic lymphomas were classified as the diffuse large cleaved cell type. The cells of the 35 enzootic lymphomas expressed a consistent immunophenotype represented by MHCII+, γ-heavy chain+, and λ-light chain+; this constellation of markers indicated a mature B-cell phenotype. The three sporadic lymphomas failed to express MHCII antigen despite the presence of other B-cell antigens. There was no correlation between morphologic cell type and immunophenotype in these bovine lymphomas.
Original language | English (US) |
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Pages (from-to) | 222-225 |
Number of pages | 4 |
Journal | Veterinary Pathology |
Volume | 34 |
Issue number | 3 |
State | Published - May 1997 |
Externally published | Yes |
Keywords
- Bovine leukemia virus
- Cattle
- Enzootic bovine lymphoma
- Immunoperoxidase
- Immunophenotype
- National Cancer Institute Working Formulation
- Non-Hodgkin's lymphoma
- Sporadic bovine lymphoma
ASJC Scopus subject areas
- veterinary(all)