Abstract
A prospective analysis of 38 cases of bovine lymphoma was performed. Thirty-five of the lymphomas were considered enzootic because of serologic or molecular biologic association with the bovine leukemia virus (BLV). The three remaining cases were in cattle < 1 year of age and were not associated with BLV and hence were considered sporadic lymphomas. Utilizing the National Cancer Institute Working Formulation for the morphologic classification of human non-Hodgkin's lymphoma, 54.3% (19/35) of the enzootic lymphomas were classified as the diffuse large cleaved cell type. The cells of the 35 enzootic lymphomas expressed a consistent immunophenotype represented by MHCII+, γ-heavy chain+, and λ-light chain+; this constellation of markers indicated a mature B-cell phenotype. The three sporadic lymphomas failed to express MHCII antigen despite the presence of other B-cell antigens. There was no correlation between morphologic cell type and immunophenotype in these bovine lymphomas.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 222-225 |
| Number of pages | 4 |
| Journal | Veterinary Pathology |
| Volume | 34 |
| Issue number | 3 |
| State | Published - May 1997 |
| Externally published | Yes |
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Keywords
- Bovine leukemia virus
- Cattle
- Enzootic bovine lymphoma
- Immunoperoxidase
- Immunophenotype
- National Cancer Institute Working Formulation
- Non-Hodgkin's lymphoma
- Sporadic bovine lymphoma
ASJC Scopus subject areas
- veterinary(all)
Cite this
The Immunophenotypic Characterization of Bovine Lymphomas. / Vernau, William; Jacobs, R. M.; Valli, V. E O; Heeney, J. L.
In: Veterinary Pathology, Vol. 34, No. 3, 05.1997, p. 222-225.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The Immunophenotypic Characterization of Bovine Lymphomas
AU - Vernau, William
AU - Jacobs, R. M.
AU - Valli, V. E O
AU - Heeney, J. L.
PY - 1997/5
Y1 - 1997/5
N2 - A prospective analysis of 38 cases of bovine lymphoma was performed. Thirty-five of the lymphomas were considered enzootic because of serologic or molecular biologic association with the bovine leukemia virus (BLV). The three remaining cases were in cattle < 1 year of age and were not associated with BLV and hence were considered sporadic lymphomas. Utilizing the National Cancer Institute Working Formulation for the morphologic classification of human non-Hodgkin's lymphoma, 54.3% (19/35) of the enzootic lymphomas were classified as the diffuse large cleaved cell type. The cells of the 35 enzootic lymphomas expressed a consistent immunophenotype represented by MHCII+, γ-heavy chain+, and λ-light chain+; this constellation of markers indicated a mature B-cell phenotype. The three sporadic lymphomas failed to express MHCII antigen despite the presence of other B-cell antigens. There was no correlation between morphologic cell type and immunophenotype in these bovine lymphomas.
AB - A prospective analysis of 38 cases of bovine lymphoma was performed. Thirty-five of the lymphomas were considered enzootic because of serologic or molecular biologic association with the bovine leukemia virus (BLV). The three remaining cases were in cattle < 1 year of age and were not associated with BLV and hence were considered sporadic lymphomas. Utilizing the National Cancer Institute Working Formulation for the morphologic classification of human non-Hodgkin's lymphoma, 54.3% (19/35) of the enzootic lymphomas were classified as the diffuse large cleaved cell type. The cells of the 35 enzootic lymphomas expressed a consistent immunophenotype represented by MHCII+, γ-heavy chain+, and λ-light chain+; this constellation of markers indicated a mature B-cell phenotype. The three sporadic lymphomas failed to express MHCII antigen despite the presence of other B-cell antigens. There was no correlation between morphologic cell type and immunophenotype in these bovine lymphomas.
KW - Bovine leukemia virus
KW - Cattle
KW - Enzootic bovine lymphoma
KW - Immunoperoxidase
KW - Immunophenotype
KW - National Cancer Institute Working Formulation
KW - Non-Hodgkin's lymphoma
KW - Sporadic bovine lymphoma
UR - http://www.scopus.com/inward/record.url?scp=0031137524&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0031137524&partnerID=8YFLogxK
M3 - Article
C2 - 9163878
AN - SCOPUS:0031137524
VL - 34
SP - 222
EP - 225
JO - Veterinary Pathology
JF - Veterinary Pathology
SN - 0300-9858
IS - 3
ER -