The Immunophenotypic Characterization of Bovine Lymphomas

William Vernau, R. M. Jacobs, V. E O Valli, J. L. Heeney

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

A prospective analysis of 38 cases of bovine lymphoma was performed. Thirty-five of the lymphomas were considered enzootic because of serologic or molecular biologic association with the bovine leukemia virus (BLV). The three remaining cases were in cattle < 1 year of age and were not associated with BLV and hence were considered sporadic lymphomas. Utilizing the National Cancer Institute Working Formulation for the morphologic classification of human non-Hodgkin's lymphoma, 54.3% (19/35) of the enzootic lymphomas were classified as the diffuse large cleaved cell type. The cells of the 35 enzootic lymphomas expressed a consistent immunophenotype represented by MHCII+, γ-heavy chain+, and λ-light chain+; this constellation of markers indicated a mature B-cell phenotype. The three sporadic lymphomas failed to express MHCII antigen despite the presence of other B-cell antigens. There was no correlation between morphologic cell type and immunophenotype in these bovine lymphomas.

Original languageEnglish (US)
Pages (from-to)222-225
Number of pages4
JournalVeterinary Pathology
Volume34
Issue number3
StatePublished - May 1997
Externally publishedYes

Fingerprint

Enzootic Bovine Leukosis
enzootic bovine leukosis
lymphoma
Lymphoma
Bovine Leukemia Virus
Bovine leukemia virus
B-lymphocytes
B-Lymphocytes
non-Hodgkin lymphoma
antigens
Antigens
National Cancer Institute (U.S.)
cells
Non-Hodgkin's Lymphoma
Phenotype
Light
phenotype
neoplasms
cattle

Keywords

  • Bovine leukemia virus
  • Cattle
  • Enzootic bovine lymphoma
  • Immunoperoxidase
  • Immunophenotype
  • National Cancer Institute Working Formulation
  • Non-Hodgkin's lymphoma
  • Sporadic bovine lymphoma

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Vernau, W., Jacobs, R. M., Valli, V. E. O., & Heeney, J. L. (1997). The Immunophenotypic Characterization of Bovine Lymphomas. Veterinary Pathology, 34(3), 222-225.

The Immunophenotypic Characterization of Bovine Lymphomas. / Vernau, William; Jacobs, R. M.; Valli, V. E O; Heeney, J. L.

In: Veterinary Pathology, Vol. 34, No. 3, 05.1997, p. 222-225.

Research output: Contribution to journalArticle

Vernau, W, Jacobs, RM, Valli, VEO & Heeney, JL 1997, 'The Immunophenotypic Characterization of Bovine Lymphomas', Veterinary Pathology, vol. 34, no. 3, pp. 222-225.
Vernau W, Jacobs RM, Valli VEO, Heeney JL. The Immunophenotypic Characterization of Bovine Lymphomas. Veterinary Pathology. 1997 May;34(3):222-225.
Vernau, William ; Jacobs, R. M. ; Valli, V. E O ; Heeney, J. L. / The Immunophenotypic Characterization of Bovine Lymphomas. In: Veterinary Pathology. 1997 ; Vol. 34, No. 3. pp. 222-225.
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