The Immunophenotypic Characterization of Bovine Lymphomas

William Vernau, R. M. Jacobs, V. E O Valli, J. L. Heeney

Research output: Contribution to journalArticlepeer-review

32 Scopus citations


A prospective analysis of 38 cases of bovine lymphoma was performed. Thirty-five of the lymphomas were considered enzootic because of serologic or molecular biologic association with the bovine leukemia virus (BLV). The three remaining cases were in cattle < 1 year of age and were not associated with BLV and hence were considered sporadic lymphomas. Utilizing the National Cancer Institute Working Formulation for the morphologic classification of human non-Hodgkin's lymphoma, 54.3% (19/35) of the enzootic lymphomas were classified as the diffuse large cleaved cell type. The cells of the 35 enzootic lymphomas expressed a consistent immunophenotype represented by MHCII+, γ-heavy chain+, and λ-light chain+; this constellation of markers indicated a mature B-cell phenotype. The three sporadic lymphomas failed to express MHCII antigen despite the presence of other B-cell antigens. There was no correlation between morphologic cell type and immunophenotype in these bovine lymphomas.

Original languageEnglish (US)
Pages (from-to)222-225
Number of pages4
JournalVeterinary Pathology
Issue number3
StatePublished - May 1997
Externally publishedYes


  • Bovine leukemia virus
  • Cattle
  • Enzootic bovine lymphoma
  • Immunoperoxidase
  • Immunophenotype
  • National Cancer Institute Working Formulation
  • Non-Hodgkin's lymphoma
  • Sporadic bovine lymphoma

ASJC Scopus subject areas

  • veterinary(all)


Dive into the research topics of 'The Immunophenotypic Characterization of Bovine Lymphomas'. Together they form a unique fingerprint.

Cite this