Abstract
An understanding of the immunobiology of primary sclerosing cholangitis (PSC) is essential to improving both diagnosis and treatment. There have been significant gains in the discovery of genetic polymorphisms that generate susceptibility to disease, but only limited data on etiologic events that may initiate the inflammatory response. Colonic inflammation produces memory T cells that have the ability to bind both biliary and colonic endothelial cells. One possible mechanism for the development of PSC is the homing of these memory T cells to the biliary tree. In addition, TNFα may contribute to the oxidative damage of the biliary system. Finally, although speculative, mononuclear cell responses against biliary epithelial cells may create a persistent inflammatory response, eventually leading to fibrosis.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 137-143 |
| Number of pages | 7 |
| Journal | Autoimmunity Reviews |
| Volume | 4 |
| Issue number | 3 |
| DOIs | |
| State | Published - Mar 2005 |
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Keywords
- Autoantibodies
- Bacterial antigens
- HLA polymorphisms
- Immunobiology
- Lymphocyte homing
- Primary sclerosing cholangitis
- TNFα
ASJC Scopus subject areas
- Immunology
- Immunology and Allergy
Cite this
The immunobiology of primary sclerosing cholangitis. / Aoki, Christopher A.; Bowlus, Christopher; Gershwin, M. Eric.
In: Autoimmunity Reviews, Vol. 4, No. 3, 03.2005, p. 137-143.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The immunobiology of primary sclerosing cholangitis
AU - Aoki, Christopher A.
AU - Bowlus, Christopher
AU - Gershwin, M. Eric
PY - 2005/3
Y1 - 2005/3
N2 - An understanding of the immunobiology of primary sclerosing cholangitis (PSC) is essential to improving both diagnosis and treatment. There have been significant gains in the discovery of genetic polymorphisms that generate susceptibility to disease, but only limited data on etiologic events that may initiate the inflammatory response. Colonic inflammation produces memory T cells that have the ability to bind both biliary and colonic endothelial cells. One possible mechanism for the development of PSC is the homing of these memory T cells to the biliary tree. In addition, TNFα may contribute to the oxidative damage of the biliary system. Finally, although speculative, mononuclear cell responses against biliary epithelial cells may create a persistent inflammatory response, eventually leading to fibrosis.
AB - An understanding of the immunobiology of primary sclerosing cholangitis (PSC) is essential to improving both diagnosis and treatment. There have been significant gains in the discovery of genetic polymorphisms that generate susceptibility to disease, but only limited data on etiologic events that may initiate the inflammatory response. Colonic inflammation produces memory T cells that have the ability to bind both biliary and colonic endothelial cells. One possible mechanism for the development of PSC is the homing of these memory T cells to the biliary tree. In addition, TNFα may contribute to the oxidative damage of the biliary system. Finally, although speculative, mononuclear cell responses against biliary epithelial cells may create a persistent inflammatory response, eventually leading to fibrosis.
KW - Autoantibodies
KW - Bacterial antigens
KW - HLA polymorphisms
KW - Immunobiology
KW - Lymphocyte homing
KW - Primary sclerosing cholangitis
KW - TNFα
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UR - http://www.scopus.com/inward/citedby.url?scp=16844374625&partnerID=8YFLogxK
U2 - 10.1016/j.autrev.2004.09.003
DO - 10.1016/j.autrev.2004.09.003
M3 - Article
C2 - 15823499
AN - SCOPUS:16844374625
VL - 4
SP - 137
EP - 143
JO - Autoimmunity Reviews
JF - Autoimmunity Reviews
SN - 1568-9972
IS - 3
ER -