The immunobiology of Henoch-Schönlein purpura

Yao Hsu Yang, Ya Hui Chuang, Li Chieh Wang, Hsin Yi Huang, M. Eric Gershwin, Bor Luen Chiang

Research output: Contribution to journalArticlepeer-review

95 Scopus citations


Henoch-Schönlein purpura (HSP) is a common but enigmatic systemic small vessel vasculitis that primarily affects children. Although the etiology of this disease is unknown, there are tantalizing clues on the natural history and immunopathogenesis. This article reviews these clues including aspects of disease-associated pathogens, immune regulation, with a focus on IgA, and finally the immunogenetic background of host. We also present a hypothetical model for the development of HSP and submit that this paradigm will be a generic one for similar vasculopathies.

Original languageEnglish (US)
Pages (from-to)179-184
Number of pages6
JournalAutoimmunity Reviews
Issue number3
StatePublished - Jan 2008


  • Henoch-Schönlein purpura
  • IgA
  • Immune regulation
  • Infection and Autoimmunity
  • Inflammation
  • Vasculitis

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy


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