The immunobiology of bile and biliary epithelium

Sandra Reynoso-Paz, Ross L. Coppel, Ian R. Mackay, Nathan M. Bass, Aftab A. Ansari, M. Eric Gershwin

Research output: Contribution to journalArticle

87 Citations (Scopus)

Abstract

Long thought to be just a simple pipe involved in the delivery of bile from hepatocytes to the gallbladder and intestine, bile ducts are now regarded as highly dynamic structures consisting of cell populations involved in formation, transport and modification of bile by both secretory and absorptive processes. In fact, both bile and biliary epithelium appear to have active immunologic roles in both innate and adaptive immune responses. These roles are becoming increasingly clear as techniques have been developed allowing for the study of bile and biliary epithelial cells (BECs) in mucosal immunity. Bile is actively involved in the transport of immunoglobulin to the intestine, while BECs secrete chemokines and cytokines and serve to localize the immune response by expressing critical cell adhesion molecules. Evidence suggests that BECs may also function as professional antigen-presenting cells (APC) and, in the process, contribute to the modulation of inflammatory reactions. Bile ducts and, in particular, BECs, are the primary site of damage in several immunologically mediated liver diseases. Progress in these important areas has been rapid and forms the basis of this review.

Original languageEnglish (US)
Pages (from-to)351-357
Number of pages7
JournalHepatology
Volume30
Issue number2
DOIs
StatePublished - 1999

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Bile
Epithelium
Epithelial Cells
Bile Ducts
Intestines
Mucosal Immunity
Secretory Pathway
Cell Adhesion Molecules
Adaptive Immunity
Antigen-Presenting Cells
Gallbladder
Chemokines
Innate Immunity
Immunoglobulins
Liver Diseases
Hepatocytes
Cytokines
Population

ASJC Scopus subject areas

  • Hepatology

Cite this

Reynoso-Paz, S., Coppel, R. L., Mackay, I. R., Bass, N. M., Ansari, A. A., & Gershwin, M. E. (1999). The immunobiology of bile and biliary epithelium. Hepatology, 30(2), 351-357. https://doi.org/10.1002/hep.510300218

The immunobiology of bile and biliary epithelium. / Reynoso-Paz, Sandra; Coppel, Ross L.; Mackay, Ian R.; Bass, Nathan M.; Ansari, Aftab A.; Gershwin, M. Eric.

In: Hepatology, Vol. 30, No. 2, 1999, p. 351-357.

Research output: Contribution to journalArticle

Reynoso-Paz, S, Coppel, RL, Mackay, IR, Bass, NM, Ansari, AA & Gershwin, ME 1999, 'The immunobiology of bile and biliary epithelium', Hepatology, vol. 30, no. 2, pp. 351-357. https://doi.org/10.1002/hep.510300218
Reynoso-Paz S, Coppel RL, Mackay IR, Bass NM, Ansari AA, Gershwin ME. The immunobiology of bile and biliary epithelium. Hepatology. 1999;30(2):351-357. https://doi.org/10.1002/hep.510300218
Reynoso-Paz, Sandra ; Coppel, Ross L. ; Mackay, Ian R. ; Bass, Nathan M. ; Ansari, Aftab A. ; Gershwin, M. Eric. / The immunobiology of bile and biliary epithelium. In: Hepatology. 1999 ; Vol. 30, No. 2. pp. 351-357.
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