The IL-4/IL-13 axis in skin fibrosis and scarring: mechanistic concepts and therapeutic targets

Julie K. Nguyen, Evan Austin, Alisen Huang, Andrew Mamalis, Jared Jagdeo

Research output: Contribution to journalReview article

Abstract

Skin fibrosis, characterized by excessive fibroblast proliferation and extracellular matrix deposition in the dermis, is the histopathologic hallmark of dermatologic diseases such as systemic sclerosis, hypertrophic scars, and keloids. Effective anti-scarring therapeutics remain an unmet need, underscoring the complex pathophysiologic mechanisms of skin fibrosis. The Th2 cytokines interleukin (IL)-4 and IL-13 have been implicated as key mediators in the pathogenesis of fibroproliferative disorders. The goal of this article is to summarize the current understanding of the role of the IL-4/IL-13 axis in wound healing and skin fibrosis. We conducted a literature search to identify research studies investigating the roles of IL-4 and IL-13 in fibrotic skin diseases. While transforming growth factor-beta has long been regarded as the main driver of fibrotic processes, research into the cellular and molecular biology of wound healing has revealed other pathways that promote scar tissue formation. IL-4 and IL-13 are important mediators of skin fibrosis, supported by evidence from in vitro data, animal models of fibrosis, and clinical studies. Overactive signaling of the IL-4/IL-13 axis contributes to the initiation and perpetuation of fibrotic skin diseases. Further insights into the IL-4/IL-13 axis may reveal potential targets for the development of novel therapies that prevent or treat fibrotic skin diseases.

Original languageEnglish (US)
JournalArchives of Dermatological Research
DOIs
StateAccepted/In press - Jan 1 2019
Externally publishedYes

Fingerprint

Interleukin-13
Interleukin-4
Cicatrix
Fibrosis
Skin
Skin Diseases
Wound Healing
Therapeutics
Hypertrophic Cicatrix
Keloid
Systemic Scleroderma
Dermis
Research
Transforming Growth Factor beta
Extracellular Matrix
Cell Biology
Molecular Biology
Animal Models
Fibroblasts
Cytokines

Keywords

  • Cytokines
  • Interleukin-13
  • Interleukin-4
  • Scarring
  • Skin fibrosis

ASJC Scopus subject areas

  • Dermatology

Cite this

The IL-4/IL-13 axis in skin fibrosis and scarring : mechanistic concepts and therapeutic targets. / Nguyen, Julie K.; Austin, Evan; Huang, Alisen; Mamalis, Andrew; Jagdeo, Jared.

In: Archives of Dermatological Research, 01.01.2019.

Research output: Contribution to journalReview article

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