The IL-23/IL-17 axis in psoriatic arthritis

Erika Suzuki, Elizabeth D. Mellins, M. Eric Gershwin, Frank O. Nestle, Iannis Adamopoulos

Research output: Contribution to journalArticle

93 Scopus citations

Abstract

Psoriatic arthritis (PsA) is an immune-mediated chronic inflammatory disease, affecting both the skin and joints. Disease progression is associated with aberrant cytokine expression, and TNF blockade is the most successful therapy to date. However, not all patients are responsive to anti-TNF treatment, highlighting the need to better understand the cellular and molecular mechanisms that govern the disease. PsA associations with single nucleotide polymorphisms in IL23R as well as TRAF3IP2 (Act1), a molecule downstream of the IL-17 receptor (IL-17R), have linked the IL-23/IL-17 axis to disease pathology. Although both cytokines are implicated in PsA, a full picture of their cellular targets and pathogenic mechanisms has not yet emerged. In this review, we focus on the IL-23/IL-17 axis-elicited responses mediated by osteoclasts, keratinocytes and neutrophils. Expanding our understanding of the cellular and molecular mechanisms that dictate pathogenicity in PsA will contribute to developing novel treatment strategies to combat disease.

Original languageEnglish (US)
Pages (from-to)496-502
Number of pages7
JournalAutoimmunity Reviews
Volume13
Issue number4-5
DOIs
StatePublished - 2014

Keywords

  • IL-17
  • IL-23
  • NF-κB
  • Psoriatic arthritis

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

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