Abstract
Non-typhoidal Salmonella (NTS) serotypes cause a localized gastroenteritis in immunocompetent individuals. In contrast, primary immunodeficiencies that impair interleukin-23 (IL-23)-dependent pathways are associated in humans with disseminated NTS bloodstream infections (bacteraemia). The recent use of animal models has helped to define the role the IL-23 axis plays during NTS gastroenteritis, but additional work is needed to elucidate how this host defence pathway prevents NTS bacteraemia.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1639-1647 |
| Number of pages | 9 |
| Journal | Cellular Microbiology |
| Volume | 13 |
| Issue number | 11 |
| DOIs | |
| State | Published - Nov 2011 |
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ASJC Scopus subject areas
- Microbiology
- Immunology
- Virology
Cite this
The IL-23 axis in Salmonella gastroenteritis. / Godinez, Ivan; Keestra, A. Marijke; Spees, Alanna; Baumler, Andreas J.
In: Cellular Microbiology, Vol. 13, No. 11, 11.2011, p. 1639-1647.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The IL-23 axis in Salmonella gastroenteritis
AU - Godinez, Ivan
AU - Keestra, A. Marijke
AU - Spees, Alanna
AU - Baumler, Andreas J
PY - 2011/11
Y1 - 2011/11
N2 - Non-typhoidal Salmonella (NTS) serotypes cause a localized gastroenteritis in immunocompetent individuals. In contrast, primary immunodeficiencies that impair interleukin-23 (IL-23)-dependent pathways are associated in humans with disseminated NTS bloodstream infections (bacteraemia). The recent use of animal models has helped to define the role the IL-23 axis plays during NTS gastroenteritis, but additional work is needed to elucidate how this host defence pathway prevents NTS bacteraemia.
AB - Non-typhoidal Salmonella (NTS) serotypes cause a localized gastroenteritis in immunocompetent individuals. In contrast, primary immunodeficiencies that impair interleukin-23 (IL-23)-dependent pathways are associated in humans with disseminated NTS bloodstream infections (bacteraemia). The recent use of animal models has helped to define the role the IL-23 axis plays during NTS gastroenteritis, but additional work is needed to elucidate how this host defence pathway prevents NTS bacteraemia.
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UR - http://www.scopus.com/inward/citedby.url?scp=80054095579&partnerID=8YFLogxK
U2 - 10.1111/j.1462-5822.2011.01637.x
DO - 10.1111/j.1462-5822.2011.01637.x
M3 - Article
C2 - 21740501
AN - SCOPUS:80054095579
VL - 13
SP - 1639
EP - 1647
JO - Cellular Microbiology
JF - Cellular Microbiology
SN - 1462-5814
IS - 11
ER -