The IL-23 axis in Salmonella gastroenteritis

Ivan Godinez, A. Marijke Keestra, Alanna Spees, Andreas J Baumler

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

Non-typhoidal Salmonella (NTS) serotypes cause a localized gastroenteritis in immunocompetent individuals. In contrast, primary immunodeficiencies that impair interleukin-23 (IL-23)-dependent pathways are associated in humans with disseminated NTS bloodstream infections (bacteraemia). The recent use of animal models has helped to define the role the IL-23 axis plays during NTS gastroenteritis, but additional work is needed to elucidate how this host defence pathway prevents NTS bacteraemia.

Original languageEnglish (US)
Pages (from-to)1639-1647
Number of pages9
JournalCellular Microbiology
Volume13
Issue number11
DOIs
StatePublished - Nov 2011

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Virology

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