The IL-23 axis in Salmonella gastroenteritis

Ivan Godinez; A. Marijke Keestra; Alanna Spees; Andreas J Baumler

doi:10.1111/j.1462-5822.2011.01637.x

The IL-23 axis in Salmonella gastroenteritis

Ivan Godinez, A. Marijke Keestra, Alanna Spees, Andreas J Baumler

Medical Microbiology and Immunology

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

Non-typhoidal Salmonella (NTS) serotypes cause a localized gastroenteritis in immunocompetent individuals. In contrast, primary immunodeficiencies that impair interleukin-23 (IL-23)-dependent pathways are associated in humans with disseminated NTS bloodstream infections (bacteraemia). The recent use of animal models has helped to define the role the IL-23 axis plays during NTS gastroenteritis, but additional work is needed to elucidate how this host defence pathway prevents NTS bacteraemia.

Original language	English (US)
Pages (from-to)	1639-1647
Number of pages	9
Journal	Cellular Microbiology
Volume	13
Issue number	11
DOIs	https://doi.org/10.1111/j.1462-5822.2011.01637.x
State	Published - Nov 2011

ASJC Scopus subject areas

Microbiology
Immunology
Virology

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10.1111/j.1462-5822.2011.01637.x

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AB - Non-typhoidal Salmonella (NTS) serotypes cause a localized gastroenteritis in immunocompetent individuals. In contrast, primary immunodeficiencies that impair interleukin-23 (IL-23)-dependent pathways are associated in humans with disseminated NTS bloodstream infections (bacteraemia). The recent use of animal models has helped to define the role the IL-23 axis plays during NTS gastroenteritis, but additional work is needed to elucidate how this host defence pathway prevents NTS bacteraemia.

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The IL-23 axis in Salmonella gastroenteritis

Abstract

ASJC Scopus subject areas

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