Abstract
Non-typhoidal Salmonella (NTS) serotypes cause a localized gastroenteritis in immunocompetent individuals. In contrast, primary immunodeficiencies that impair interleukin-23 (IL-23)-dependent pathways are associated in humans with disseminated NTS bloodstream infections (bacteraemia). The recent use of animal models has helped to define the role the IL-23 axis plays during NTS gastroenteritis, but additional work is needed to elucidate how this host defence pathway prevents NTS bacteraemia.
Original language | English (US) |
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Pages (from-to) | 1639-1647 |
Number of pages | 9 |
Journal | Cellular Microbiology |
Volume | 13 |
Issue number | 11 |
DOIs | |
State | Published - Nov 2011 |
ASJC Scopus subject areas
- Microbiology
- Immunology
- Virology