Abstract
Non-typhoidal Salmonella (NTS) serotypes cause a localized gastroenteritis in immunocompetent individuals. In contrast, primary immunodeficiencies that impair interleukin-23 (IL-23)-dependent pathways are associated in humans with disseminated NTS bloodstream infections (bacteraemia). The recent use of animal models has helped to define the role the IL-23 axis plays during NTS gastroenteritis, but additional work is needed to elucidate how this host defence pathway prevents NTS bacteraemia.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1639-1647 |
| Number of pages | 9 |
| Journal | Cellular Microbiology |
| Volume | 13 |
| Issue number | 11 |
| DOIs | |
| State | Published - Nov 2011 |
ASJC Scopus subject areas
- Microbiology
- Immunology
- Virology
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Cite this
Godinez, I., Keestra, A. M., Spees, A., & Baumler, A. J. (2011). The IL-23 axis in Salmonella gastroenteritis. Cellular Microbiology, 13(11), 1639-1647. https://doi.org/10.1111/j.1462-5822.2011.01637.x