The identification and cloning of the murine genes encoding the liver specific F alloantigens

Suzanne S Teuber, Ross L. Coppel, Aftab A. Ansari, Patrick S Leung, Rachel Neve, Ian R. Mackay, M. Eric Gershwin

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The liver specific F alloantigen is a highly conserved abundant protein found in hepatic cytoplasm; smaller amounts are detected in renal tubule cells and the perikaryon cells of the central nervous system. Although the biological function of the F alloantigen is unknown, the immune response to F has been extensively studied as a murine model of tolerance and autoimmunity. Murine F exists in two allelic forms, designated F type 1 and type 2, each of approximately 43 kDa. The immune response to the allotypic form is restricted to mouse strains of I-Ak. Responding strains immunized with allotypic F break tolerance and produce precipitating antibody that reacts with both allelic forms, i.e., immunogen and self. Thus an autoantibody is produced. Using the previously isolated rat F cDNA as a probe, we report the cloning and sequencing of the two murine F allotypes. These two alleles are nearly homologous except at the extremes of the coding sequence. There are a number of regions within the F sequence that are similar to peptides that interact specifically with I-Ak. In particular, there is a sequence near the carboxy terminus, where the two allotypes differ, that has homology to the I-Ak restricted malarial antigen peptide of the ring-infected erythrocyte surface antigen (RESA).

Original languageEnglish (US)
Pages (from-to)857-870
Number of pages14
JournalJournal of Autoimmunity
Volume4
Issue number6
DOIs
StatePublished - 1991

Fingerprint

Isoantigens
Organism Cloning
Peptides
Liver
Surface Antigens
Autoimmunity
Autoantibodies
Genes
Cytoplasm
Central Nervous System
Complementary DNA
Erythrocytes
Alleles
Kidney
Antigens
Antibodies
Proteins

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

The identification and cloning of the murine genes encoding the liver specific F alloantigens. / Teuber, Suzanne S; Coppel, Ross L.; Ansari, Aftab A.; Leung, Patrick S; Neve, Rachel; Mackay, Ian R.; Gershwin, M. Eric.

In: Journal of Autoimmunity, Vol. 4, No. 6, 1991, p. 857-870.

Research output: Contribution to journalArticle

Teuber, Suzanne S ; Coppel, Ross L. ; Ansari, Aftab A. ; Leung, Patrick S ; Neve, Rachel ; Mackay, Ian R. ; Gershwin, M. Eric. / The identification and cloning of the murine genes encoding the liver specific F alloantigens. In: Journal of Autoimmunity. 1991 ; Vol. 4, No. 6. pp. 857-870.
@article{b9e74e71102e4bb5a6ec7d817abeaf05,
title = "The identification and cloning of the murine genes encoding the liver specific F alloantigens",
abstract = "The liver specific F alloantigen is a highly conserved abundant protein found in hepatic cytoplasm; smaller amounts are detected in renal tubule cells and the perikaryon cells of the central nervous system. Although the biological function of the F alloantigen is unknown, the immune response to F has been extensively studied as a murine model of tolerance and autoimmunity. Murine F exists in two allelic forms, designated F type 1 and type 2, each of approximately 43 kDa. The immune response to the allotypic form is restricted to mouse strains of I-Ak. Responding strains immunized with allotypic F break tolerance and produce precipitating antibody that reacts with both allelic forms, i.e., immunogen and self. Thus an autoantibody is produced. Using the previously isolated rat F cDNA as a probe, we report the cloning and sequencing of the two murine F allotypes. These two alleles are nearly homologous except at the extremes of the coding sequence. There are a number of regions within the F sequence that are similar to peptides that interact specifically with I-Ak. In particular, there is a sequence near the carboxy terminus, where the two allotypes differ, that has homology to the I-Ak restricted malarial antigen peptide of the ring-infected erythrocyte surface antigen (RESA).",
author = "Teuber, {Suzanne S} and Coppel, {Ross L.} and Ansari, {Aftab A.} and Leung, {Patrick S} and Rachel Neve and Mackay, {Ian R.} and Gershwin, {M. Eric}",
year = "1991",
doi = "10.1016/0896-8411(91)90049-I",
language = "English (US)",
volume = "4",
pages = "857--870",
journal = "Journal of Autoimmunity",
issn = "0896-8411",
publisher = "Academic Press Inc.",
number = "6",

}

TY - JOUR

T1 - The identification and cloning of the murine genes encoding the liver specific F alloantigens

AU - Teuber, Suzanne S

AU - Coppel, Ross L.

AU - Ansari, Aftab A.

AU - Leung, Patrick S

AU - Neve, Rachel

AU - Mackay, Ian R.

AU - Gershwin, M. Eric

PY - 1991

Y1 - 1991

N2 - The liver specific F alloantigen is a highly conserved abundant protein found in hepatic cytoplasm; smaller amounts are detected in renal tubule cells and the perikaryon cells of the central nervous system. Although the biological function of the F alloantigen is unknown, the immune response to F has been extensively studied as a murine model of tolerance and autoimmunity. Murine F exists in two allelic forms, designated F type 1 and type 2, each of approximately 43 kDa. The immune response to the allotypic form is restricted to mouse strains of I-Ak. Responding strains immunized with allotypic F break tolerance and produce precipitating antibody that reacts with both allelic forms, i.e., immunogen and self. Thus an autoantibody is produced. Using the previously isolated rat F cDNA as a probe, we report the cloning and sequencing of the two murine F allotypes. These two alleles are nearly homologous except at the extremes of the coding sequence. There are a number of regions within the F sequence that are similar to peptides that interact specifically with I-Ak. In particular, there is a sequence near the carboxy terminus, where the two allotypes differ, that has homology to the I-Ak restricted malarial antigen peptide of the ring-infected erythrocyte surface antigen (RESA).

AB - The liver specific F alloantigen is a highly conserved abundant protein found in hepatic cytoplasm; smaller amounts are detected in renal tubule cells and the perikaryon cells of the central nervous system. Although the biological function of the F alloantigen is unknown, the immune response to F has been extensively studied as a murine model of tolerance and autoimmunity. Murine F exists in two allelic forms, designated F type 1 and type 2, each of approximately 43 kDa. The immune response to the allotypic form is restricted to mouse strains of I-Ak. Responding strains immunized with allotypic F break tolerance and produce precipitating antibody that reacts with both allelic forms, i.e., immunogen and self. Thus an autoantibody is produced. Using the previously isolated rat F cDNA as a probe, we report the cloning and sequencing of the two murine F allotypes. These two alleles are nearly homologous except at the extremes of the coding sequence. There are a number of regions within the F sequence that are similar to peptides that interact specifically with I-Ak. In particular, there is a sequence near the carboxy terminus, where the two allotypes differ, that has homology to the I-Ak restricted malarial antigen peptide of the ring-infected erythrocyte surface antigen (RESA).

UR - http://www.scopus.com/inward/record.url?scp=0026356011&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026356011&partnerID=8YFLogxK

U2 - 10.1016/0896-8411(91)90049-I

DO - 10.1016/0896-8411(91)90049-I

M3 - Article

C2 - 1667467

AN - SCOPUS:0026356011

VL - 4

SP - 857

EP - 870

JO - Journal of Autoimmunity

JF - Journal of Autoimmunity

SN - 0896-8411

IS - 6

ER -