The hydration dynamics of polyelectrolyte gels with applications to cell motility and drug delivery

Charles W. Wolgemuth, Alexander Mogilner, George Oster

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

We combine the physics of gels with the hydrodynamics of two-phase fluids to construct a set of equations that describe the hydration dynamics of polyelectrolyte gels. We use the model to address three problems. First, we express the effective diffusion constants for neutral and charged spherically distributed gels in terms of microscopic parameters. Second, we use the model to describe the locomotion of nematode sperm cells. Finally, we describe the swelling dynamics of polyelectrolyte gels used for drug release.

Original languageEnglish (US)
Pages (from-to)146-158
Number of pages13
JournalEuropean Biophysics Journal
Volume33
Issue number2
DOIs
StatePublished - Apr 2004

Fingerprint

Cell Movement
Gels
Pharmaceutical Preparations
Physics
Hydrodynamics
Locomotion
Spermatozoa
Polyelectrolytes

Keywords

  • Diffusion constants
  • Drug release
  • Hydration dynamics
  • Nematode sperm cells
  • Polyelectrolyte gels

ASJC Scopus subject areas

  • Biophysics

Cite this

The hydration dynamics of polyelectrolyte gels with applications to cell motility and drug delivery. / Wolgemuth, Charles W.; Mogilner, Alexander; Oster, George.

In: European Biophysics Journal, Vol. 33, No. 2, 04.2004, p. 146-158.

Research output: Contribution to journalArticle

Wolgemuth, Charles W. ; Mogilner, Alexander ; Oster, George. / The hydration dynamics of polyelectrolyte gels with applications to cell motility and drug delivery. In: European Biophysics Journal. 2004 ; Vol. 33, No. 2. pp. 146-158.
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