The human microbiome and surgical disease

Michael J. Morowitz, Trissa Babrowski, Erica M. Carlisle, Andrea Olivas, Kathleen Romanowski, John B. Seal, Donald C. Liu, John C. Alverdy

Research output: Contribution to journalReview article

32 Citations (Scopus)

Abstract

Objective: The purpose of this review article is to summarize what is currently known about microbes associated with the human body and to provide examples of how this knowledge impacts the care of surgical patients. Background: Pioneering research over the past decade has demonstrated that human beings live in close, constant contact with dynamic communities of microbial organisms. This new reality has wide-ranging implications for the care of surgical patients. METHODS AND Results: Recent advances in the culture-independent study of the human microbiome are reviewed. To illustrate the translational relevance of these studies to surgical disease, we discuss in detail what is known about the role of microbes in the pathogenesis of obesity, gastrointestinal malignancies, Crohn disease, and perioperative complications including surgical site infections and sepsis. The topics of mechanical bowel preparation and perioperative antibiotics are also discussed. Conclusions: Heightened understanding of the microbiome in coming years will likely offer opportunities to refine the prevention and treatment of a wide variety of surgical conditions.

Original languageEnglish (US)
Pages (from-to)1094-1101
Number of pages8
JournalAnnals of Surgery
Volume253
Issue number6
DOIs
StatePublished - Jun 1 2011
Externally publishedYes

Fingerprint

Microbiota
Patient Care
Surgical Wound Infection
Human Body
Crohn Disease
Sepsis
Obesity
Anti-Bacterial Agents
Research
Neoplasms
Therapeutics

ASJC Scopus subject areas

  • Surgery

Cite this

Morowitz, M. J., Babrowski, T., Carlisle, E. M., Olivas, A., Romanowski, K., Seal, J. B., ... Alverdy, J. C. (2011). The human microbiome and surgical disease. Annals of Surgery, 253(6), 1094-1101. https://doi.org/10.1097/SLA.0b013e31821175d7

The human microbiome and surgical disease. / Morowitz, Michael J.; Babrowski, Trissa; Carlisle, Erica M.; Olivas, Andrea; Romanowski, Kathleen; Seal, John B.; Liu, Donald C.; Alverdy, John C.

In: Annals of Surgery, Vol. 253, No. 6, 01.06.2011, p. 1094-1101.

Research output: Contribution to journalReview article

Morowitz, MJ, Babrowski, T, Carlisle, EM, Olivas, A, Romanowski, K, Seal, JB, Liu, DC & Alverdy, JC 2011, 'The human microbiome and surgical disease', Annals of Surgery, vol. 253, no. 6, pp. 1094-1101. https://doi.org/10.1097/SLA.0b013e31821175d7
Morowitz MJ, Babrowski T, Carlisle EM, Olivas A, Romanowski K, Seal JB et al. The human microbiome and surgical disease. Annals of Surgery. 2011 Jun 1;253(6):1094-1101. https://doi.org/10.1097/SLA.0b013e31821175d7
Morowitz, Michael J. ; Babrowski, Trissa ; Carlisle, Erica M. ; Olivas, Andrea ; Romanowski, Kathleen ; Seal, John B. ; Liu, Donald C. ; Alverdy, John C. / The human microbiome and surgical disease. In: Annals of Surgery. 2011 ; Vol. 253, No. 6. pp. 1094-1101.
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