The Human and Mouse Receptors for Hyaluronan-Mediated Motility, RHAMM, Genes (HMMR) Map to Human Chromosome 5q33.2-qter and Mouse Chromosome 11

ANDREW P. SPICER; MICHELLE L. ROLLER; SALLY A. CAMPER; John Douglas Mcpherson; JOHN J. WASMUTH; SIMIN HAKIM; CHAO WANG; EVA A. TURLEY; JOHN A. MCDONALD

doi:10.1006/geno.1995.0022

The Human and Mouse Receptors for Hyaluronan-Mediated Motility, RHAMM, Genes (HMMR) Map to Human Chromosome 5q33.2-qter and Mouse Chromosome 11

ANDREW P. SPICER, MICHELLE L. ROLLER, SALLY A. CAMPER, John Douglas Mcpherson, JOHN J. WASMUTH, SIMIN HAKIM, CHAO WANG, EVA A. TURLEY, JOHN A. MCDONALD

Biochemistry and Molecular Medicine

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

The gene for the receptor for hyaluronan-mediated motility, RHAMM (designated hyaluronan-mediated motility receptor,HMMR(human) andHmmr(mouse), for mapping purposes), was localized to human chromosome 5q33.2-qter by somatic cell and radiation hybrid analyses. Investigation of two interspecific backcrosses localized the mouse RHAMM (Hmmr) locus 18 cM from the centromere of mouse chromosome 11 within a region of synteny homology with human chromosome 5q23-q35 genes. The map position of the human RHAMM gene places it in a region comparatively rich in disease-associated genes, including those for low-frequency hearing loss, dominant limb-girdle muscular dystrophy, diastrophic dysplasia, Treacher Collins syndrome, and myeloid disorders associated with the 5q- syndrome. The RHAMM gene location and its ability to transform cells when overexpressed implicate RHAMM as a possible candidate gene in the pathogenesis of the recently described t(5;14)(q33-q34;q11) acute lymphoblastic leukemias.

Original language	English (US)
Pages (from-to)	115-117
Number of pages	3
Journal	Genomics
Volume	30
Issue number	1
DOIs	https://doi.org/10.1006/geno.1995.0022
State	Published - Nov 1995

ASJC Scopus subject areas

Genetics

Access to Document

10.1006/geno.1995.0022

Fingerprint Dive into the research topics of 'The Human and Mouse Receptors for Hyaluronan-Mediated Motility, RHAMM, Genes (HMMR) Map to Human Chromosome 5q33.2-qter and Mouse Chromosome 11'. Together they form a unique fingerprint.

Cite this

SPICER, ANDREW. P., ROLLER, MICHELLE. L., CAMPER, SALLY. A., Mcpherson, J. D., WASMUTH, JOHN. J., HAKIM, SIMIN., WANG, CHAO., TURLEY, EVA. A., & MCDONALD, JOHN. A. (1995). The Human and Mouse Receptors for Hyaluronan-Mediated Motility, RHAMM, Genes (HMMR) Map to Human Chromosome 5q33.2-qter and Mouse Chromosome 11. Genomics, 30(1), 115-117. https://doi.org/10.1006/geno.1995.0022

The Human and Mouse Receptors for Hyaluronan-Mediated Motility, RHAMM, Genes (HMMR) Map to Human Chromosome 5q33.2-qter and Mouse Chromosome 11. / SPICER, ANDREW P.; ROLLER, MICHELLE L.; CAMPER, SALLY A.; Mcpherson, John Douglas; WASMUTH, JOHN J.; HAKIM, SIMIN; WANG, CHAO; TURLEY, EVA A.; MCDONALD, JOHN A.

In: Genomics, Vol. 30, No. 1, 11.1995, p. 115-117.

Research output: Contribution to journal › Article › peer-review

SPICER, ANDREWP, ROLLER, MICHELLEL, CAMPER, SALLYA, Mcpherson, JD, WASMUTH, JOHNJ, HAKIM, SIMIN, WANG, CHAO, TURLEY, EVAA & MCDONALD, JOHNA 1995, 'The Human and Mouse Receptors for Hyaluronan-Mediated Motility, RHAMM, Genes (HMMR) Map to Human Chromosome 5q33.2-qter and Mouse Chromosome 11', Genomics, vol. 30, no. 1, pp. 115-117. https://doi.org/10.1006/geno.1995.0022

@article{ed23757e930341569a69c135a8785a44,

title = "The Human and Mouse Receptors for Hyaluronan-Mediated Motility, RHAMM, Genes (HMMR) Map to Human Chromosome 5q33.2-qter and Mouse Chromosome 11",

abstract = "The gene for the receptor for hyaluronan-mediated motility, RHAMM (designated hyaluronan-mediated motility receptor,HMMR(human) andHmmr(mouse), for mapping purposes), was localized to human chromosome 5q33.2-qter by somatic cell and radiation hybrid analyses. Investigation of two interspecific backcrosses localized the mouse RHAMM (Hmmr) locus 18 cM from the centromere of mouse chromosome 11 within a region of synteny homology with human chromosome 5q23-q35 genes. The map position of the human RHAMM gene places it in a region comparatively rich in disease-associated genes, including those for low-frequency hearing loss, dominant limb-girdle muscular dystrophy, diastrophic dysplasia, Treacher Collins syndrome, and myeloid disorders associated with the 5q- syndrome. The RHAMM gene location and its ability to transform cells when overexpressed implicate RHAMM as a possible candidate gene in the pathogenesis of the recently described t(5;14)(q33-q34;q11) acute lymphoblastic leukemias.",

author = "SPICER, {ANDREW P.} and ROLLER, {MICHELLE L.} and CAMPER, {SALLY A.} and Mcpherson, {John Douglas} and WASMUTH, {JOHN J.} and SIMIN HAKIM and CHAO WANG and TURLEY, {EVA A.} and MCDONALD, {JOHN A.}",

year = "1995",

month = nov,

doi = "10.1006/geno.1995.0022",

language = "English (US)",

volume = "30",

pages = "115--117",

journal = "Genomics",

issn = "0888-7543",

publisher = "Academic Press Inc.",

number = "1",

}

TY - JOUR

T1 - The Human and Mouse Receptors for Hyaluronan-Mediated Motility, RHAMM, Genes (HMMR) Map to Human Chromosome 5q33.2-qter and Mouse Chromosome 11

AU - SPICER, ANDREW P.

AU - ROLLER, MICHELLE L.

AU - CAMPER, SALLY A.

AU - Mcpherson, John Douglas

AU - WASMUTH, JOHN J.

AU - HAKIM, SIMIN

AU - WANG, CHAO

AU - TURLEY, EVA A.

AU - MCDONALD, JOHN A.

PY - 1995/11

Y1 - 1995/11

N2 - The gene for the receptor for hyaluronan-mediated motility, RHAMM (designated hyaluronan-mediated motility receptor,HMMR(human) andHmmr(mouse), for mapping purposes), was localized to human chromosome 5q33.2-qter by somatic cell and radiation hybrid analyses. Investigation of two interspecific backcrosses localized the mouse RHAMM (Hmmr) locus 18 cM from the centromere of mouse chromosome 11 within a region of synteny homology with human chromosome 5q23-q35 genes. The map position of the human RHAMM gene places it in a region comparatively rich in disease-associated genes, including those for low-frequency hearing loss, dominant limb-girdle muscular dystrophy, diastrophic dysplasia, Treacher Collins syndrome, and myeloid disorders associated with the 5q- syndrome. The RHAMM gene location and its ability to transform cells when overexpressed implicate RHAMM as a possible candidate gene in the pathogenesis of the recently described t(5;14)(q33-q34;q11) acute lymphoblastic leukemias.

AB - The gene for the receptor for hyaluronan-mediated motility, RHAMM (designated hyaluronan-mediated motility receptor,HMMR(human) andHmmr(mouse), for mapping purposes), was localized to human chromosome 5q33.2-qter by somatic cell and radiation hybrid analyses. Investigation of two interspecific backcrosses localized the mouse RHAMM (Hmmr) locus 18 cM from the centromere of mouse chromosome 11 within a region of synteny homology with human chromosome 5q23-q35 genes. The map position of the human RHAMM gene places it in a region comparatively rich in disease-associated genes, including those for low-frequency hearing loss, dominant limb-girdle muscular dystrophy, diastrophic dysplasia, Treacher Collins syndrome, and myeloid disorders associated with the 5q- syndrome. The RHAMM gene location and its ability to transform cells when overexpressed implicate RHAMM as a possible candidate gene in the pathogenesis of the recently described t(5;14)(q33-q34;q11) acute lymphoblastic leukemias.

UR - http://www.scopus.com/inward/record.url?scp=0028884752&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028884752&partnerID=8YFLogxK

U2 - 10.1006/geno.1995.0022

DO - 10.1006/geno.1995.0022

M3 - Article

C2 - 8595891

AN - SCOPUS:0028884752

VL - 30

SP - 115

EP - 117

JO - Genomics

JF - Genomics

SN - 0888-7543

IS - 1

ER -