The Human and Mouse Receptors for Hyaluronan-Mediated Motility, RHAMM, Genes (HMMR) Map to Human Chromosome 5q33.2-qter and Mouse Chromosome 11

ANDREW P. SPICER; MICHELLE L. ROLLER; SALLY A. CAMPER; John Douglas Mcpherson; JOHN J. WASMUTH; SIMIN HAKIM; CHAO WANG; EVA A. TURLEY; JOHN A. MCDONALD

doi:10.1006/geno.1995.0022

The Human and Mouse Receptors for Hyaluronan-Mediated Motility, RHAMM, Genes (HMMR) Map to Human Chromosome 5q33.2-qter and Mouse Chromosome 11

ANDREW P. SPICER, MICHELLE L. ROLLER, SALLY A. CAMPER, John Douglas Mcpherson, JOHN J. WASMUTH, SIMIN HAKIM, CHAO WANG, EVA A. TURLEY, JOHN A. MCDONALD

Biochemistry and Molecular Medicine

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Abstract

The gene for the receptor for hyaluronan-mediated motility, RHAMM (designated hyaluronan-mediated motility receptor,HMMR(human) andHmmr(mouse), for mapping purposes), was localized to human chromosome 5q33.2-qter by somatic cell and radiation hybrid analyses. Investigation of two interspecific backcrosses localized the mouse RHAMM (Hmmr) locus 18 cM from the centromere of mouse chromosome 11 within a region of synteny homology with human chromosome 5q23-q35 genes. The map position of the human RHAMM gene places it in a region comparatively rich in disease-associated genes, including those for low-frequency hearing loss, dominant limb-girdle muscular dystrophy, diastrophic dysplasia, Treacher Collins syndrome, and myeloid disorders associated with the 5q- syndrome. The RHAMM gene location and its ability to transform cells when overexpressed implicate RHAMM as a possible candidate gene in the pathogenesis of the recently described t(5;14)(q33-q34;q11) acute lymphoblastic leukemias.

Original language	English (US)
Pages (from-to)	115-117
Number of pages	3
Journal	Genomics
Volume	30
Issue number	1
DOIs	https://doi.org/10.1006/geno.1995.0022
State	Published - Nov 1995

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Genetics

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SPICER, ANDREW. P., ROLLER, MICHELLE. L., CAMPER, SALLY. A., Mcpherson, J. D., WASMUTH, JOHN. J., HAKIM, SIMIN., WANG, CHAO., TURLEY, EVA. A., & MCDONALD, JOHN. A. (1995). The Human and Mouse Receptors for Hyaluronan-Mediated Motility, RHAMM, Genes (HMMR) Map to Human Chromosome 5q33.2-qter and Mouse Chromosome 11. Genomics, 30(1), 115-117. https://doi.org/10.1006/geno.1995.0022

The Human and Mouse Receptors for Hyaluronan-Mediated Motility, RHAMM, Genes (HMMR) Map to Human Chromosome 5q33.2-qter and Mouse Chromosome 11. / SPICER, ANDREW P.; ROLLER, MICHELLE L.; CAMPER, SALLY A.; Mcpherson, John Douglas; WASMUTH, JOHN J.; HAKIM, SIMIN; WANG, CHAO; TURLEY, EVA A.; MCDONALD, JOHN A.

In: Genomics, Vol. 30, No. 1, 11.1995, p. 115-117.

Research output: Contribution to journal › Article

SPICER, ANDREWP, ROLLER, MICHELLEL, CAMPER, SALLYA, Mcpherson, JD, WASMUTH, JOHNJ, HAKIM, SIMIN, WANG, CHAO, TURLEY, EVAA & MCDONALD, JOHNA 1995, 'The Human and Mouse Receptors for Hyaluronan-Mediated Motility, RHAMM, Genes (HMMR) Map to Human Chromosome 5q33.2-qter and Mouse Chromosome 11', Genomics, vol. 30, no. 1, pp. 115-117. https://doi.org/10.1006/geno.1995.0022

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abstract = "The gene for the receptor for hyaluronan-mediated motility, RHAMM (designated hyaluronan-mediated motility receptor,HMMR(human) andHmmr(mouse), for mapping purposes), was localized to human chromosome 5q33.2-qter by somatic cell and radiation hybrid analyses. Investigation of two interspecific backcrosses localized the mouse RHAMM (Hmmr) locus 18 cM from the centromere of mouse chromosome 11 within a region of synteny homology with human chromosome 5q23-q35 genes. The map position of the human RHAMM gene places it in a region comparatively rich in disease-associated genes, including those for low-frequency hearing loss, dominant limb-girdle muscular dystrophy, diastrophic dysplasia, Treacher Collins syndrome, and myeloid disorders associated with the 5q- syndrome. The RHAMM gene location and its ability to transform cells when overexpressed implicate RHAMM as a possible candidate gene in the pathogenesis of the recently described t(5;14)(q33-q34;q11) acute lymphoblastic leukemias.",

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10.1006/geno.1995.0022