The Human and Mouse Receptors for Hyaluronan-Mediated Motility, RHAMM, Genes (HMMR) Map to Human Chromosome 5q33.2-qter and Mouse Chromosome 11

ANDREW P. SPICER, MICHELLE L. ROLLER, SALLY A. CAMPER, John Douglas Mcpherson, JOHN J. WASMUTH, SIMIN HAKIM, CHAO WANG, EVA A. TURLEY, JOHN A. MCDONALD

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Abstract

The gene for the receptor for hyaluronan-mediated motility, RHAMM (designated hyaluronan-mediated motility receptor,HMMR(human) andHmmr(mouse), for mapping purposes), was localized to human chromosome 5q33.2-qter by somatic cell and radiation hybrid analyses. Investigation of two interspecific backcrosses localized the mouse RHAMM (Hmmr) locus 18 cM from the centromere of mouse chromosome 11 within a region of synteny homology with human chromosome 5q23-q35 genes. The map position of the human RHAMM gene places it in a region comparatively rich in disease-associated genes, including those for low-frequency hearing loss, dominant limb-girdle muscular dystrophy, diastrophic dysplasia, Treacher Collins syndrome, and myeloid disorders associated with the 5q- syndrome. The RHAMM gene location and its ability to transform cells when overexpressed implicate RHAMM as a possible candidate gene in the pathogenesis of the recently described t(5;14)(q33-q34;q11) acute lymphoblastic leukemias.

Original languageEnglish (US)
Pages (from-to)115-117
Number of pages3
JournalGenomics
Volume30
Issue number1
DOIs
StatePublished - Nov 1995

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ASJC Scopus subject areas

  • Genetics

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SPICER, ANDREW. P., ROLLER, MICHELLE. L., CAMPER, SALLY. A., Mcpherson, J. D., WASMUTH, JOHN. J., HAKIM, SIMIN., WANG, CHAO., TURLEY, EVA. A., & MCDONALD, JOHN. A. (1995). The Human and Mouse Receptors for Hyaluronan-Mediated Motility, RHAMM, Genes (HMMR) Map to Human Chromosome 5q33.2-qter and Mouse Chromosome 11. Genomics, 30(1), 115-117. https://doi.org/10.1006/geno.1995.0022