The HIV tat gene induces dermal lesions resembling Kaposi's sarcoma in transgenic mice

Jonathan Vogel; Steven H. Hinrichs; R. Kay Reynolds; Paul A Luciw; Gilbert Jay

The HIV tat gene induces dermal lesions resembling Kaposi's sarcoma in transgenic mice

Jonathan Vogel, Steven H. Hinrichs, R. Kay Reynolds, Paul A Luciw, Gilbert Jay

Pathology and Laboratory Medicine

Research output: Contribution to journal › Article

431 Scopus citations

Abstract

When the human immunodeficiency virus transactivating gene under the control of the viral regulatory region is introduced into the germline of mice, skin lesions are induced that resemble Kaposi's sarcoma seen in AIDS. Our findings indicate that HIV could play a direct part in causing cancer.

Original language	English (US)
Pages (from-to)	606-611
Number of pages	6
Journal	Nature
Volume	335
Issue number	6191
State	Published - 1988

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title = "The HIV tat gene induces dermal lesions resembling Kaposi's sarcoma in transgenic mice",

abstract = "When the human immunodeficiency virus transactivating gene under the control of the viral regulatory region is introduced into the germline of mice, skin lesions are induced that resemble Kaposi's sarcoma seen in AIDS. Our findings indicate that HIV could play a direct part in causing cancer.",

author = "Jonathan Vogel and Hinrichs, {Steven H.} and Reynolds, {R. Kay} and Luciw, {Paul A} and Gilbert Jay",

year = "1988",

language = "English (US)",

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journal = "Nature",

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T1 - The HIV tat gene induces dermal lesions resembling Kaposi's sarcoma in transgenic mice

AU - Vogel, Jonathan

AU - Hinrichs, Steven H.

AU - Reynolds, R. Kay

AU - Luciw, Paul A

AU - Jay, Gilbert

PY - 1988

Y1 - 1988

N2 - When the human immunodeficiency virus transactivating gene under the control of the viral regulatory region is introduced into the germline of mice, skin lesions are induced that resemble Kaposi's sarcoma seen in AIDS. Our findings indicate that HIV could play a direct part in causing cancer.

AB - When the human immunodeficiency virus transactivating gene under the control of the viral regulatory region is introduced into the germline of mice, skin lesions are induced that resemble Kaposi's sarcoma seen in AIDS. Our findings indicate that HIV could play a direct part in causing cancer.

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JO - Nature

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