The HIV tat gene induces dermal lesions resembling Kaposi's sarcoma in transgenic mice

Jonathan Vogel; Steven H. Hinrichs; R. Kay Reynolds; Paul A Luciw; Gilbert Jay

The HIV tat gene induces dermal lesions resembling Kaposi's sarcoma in transgenic mice

Jonathan Vogel, Steven H. Hinrichs, R. Kay Reynolds, Paul A Luciw, Gilbert Jay

Pathology and Laboratory Medicine

Research output: Contribution to journal › Article › peer-review

433 Scopus citations

Abstract

When the human immunodeficiency virus transactivating gene under the control of the viral regulatory region is introduced into the germline of mice, skin lesions are induced that resemble Kaposi's sarcoma seen in AIDS. Our findings indicate that HIV could play a direct part in causing cancer.

Original language	English (US)
Pages (from-to)	606-611
Number of pages	6
Journal	Nature
Volume	335
Issue number	6191
State	Published - 1988

ASJC Scopus subject areas

General

Cite this

@article{35ec6bbbeaeb4e7ead8c2a670a8f43e3,

title = "The HIV tat gene induces dermal lesions resembling Kaposi's sarcoma in transgenic mice",

abstract = "When the human immunodeficiency virus transactivating gene under the control of the viral regulatory region is introduced into the germline of mice, skin lesions are induced that resemble Kaposi's sarcoma seen in AIDS. Our findings indicate that HIV could play a direct part in causing cancer.",

author = "Jonathan Vogel and Hinrichs, {Steven H.} and Reynolds, {R. Kay} and Luciw, {Paul A} and Gilbert Jay",

year = "1988",

language = "English (US)",

volume = "335",

pages = "606--611",

journal = "Nature",

issn = "0028-0836",

publisher = "Nature Publishing Group",

number = "6191",

}

TY - JOUR

T1 - The HIV tat gene induces dermal lesions resembling Kaposi's sarcoma in transgenic mice

AU - Vogel, Jonathan

AU - Hinrichs, Steven H.

AU - Reynolds, R. Kay

AU - Luciw, Paul A

AU - Jay, Gilbert

PY - 1988

Y1 - 1988

N2 - When the human immunodeficiency virus transactivating gene under the control of the viral regulatory region is introduced into the germline of mice, skin lesions are induced that resemble Kaposi's sarcoma seen in AIDS. Our findings indicate that HIV could play a direct part in causing cancer.

AB - When the human immunodeficiency virus transactivating gene under the control of the viral regulatory region is introduced into the germline of mice, skin lesions are induced that resemble Kaposi's sarcoma seen in AIDS. Our findings indicate that HIV could play a direct part in causing cancer.

UR - http://www.scopus.com/inward/record.url?scp=0023681089&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023681089&partnerID=8YFLogxK

M3 - Article

C2 - 2845275

AN - SCOPUS:0023681089

VL - 335

SP - 606

EP - 611

JO - Nature

JF - Nature

SN - 0028-0836

IS - 6191

ER -

The HIV tat gene induces dermal lesions resembling Kaposi's sarcoma in transgenic mice

Abstract

ASJC Scopus subject areas

Other files and links

Fingerprint

Cite this