The HIV tat gene induces dermal lesions resembling Kaposi's sarcoma in transgenic mice

Jonathan Vogel, Steven H. Hinrichs, R. Kay Reynolds, Paul A Luciw, Gilbert Jay

Research output: Contribution to journalArticle

431 Scopus citations

Abstract

When the human immunodeficiency virus transactivating gene under the control of the viral regulatory region is introduced into the germline of mice, skin lesions are induced that resemble Kaposi's sarcoma seen in AIDS. Our findings indicate that HIV could play a direct part in causing cancer.

Original languageEnglish (US)
Pages (from-to)606-611
Number of pages6
JournalNature
Volume335
Issue number6191
StatePublished - 1988

ASJC Scopus subject areas

  • General

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