The HIV-1 seroprevalence rate of injured patients admitted through California emergency departments

Kenneth J. Rhee, Timothy E Albertson, Kenneth W Kizer, Michael J. Hughes, Michael S. Ascher

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Study objectives: To measure the HIV seroprevalence of injured emergency department patients in a number of California hospitals and to examine the relationship between ED seroprevalence and local AIDS incidence. Design: Prospective blinded testing for HIV-1 antibody was performed on routinely collected blood samples. Setting: Ten California hospitals; group 1 included three hospitals from counties of high AIDS incidence (more than 40 cases per 100,000 population), group 2 included three hospitals from counties of intermediate AIDS incidence (20 to 40 cases per 100,000 population); and group 3 included four hospitals from counties of low AIDS incidence (less than 20 cases per 100,000 population). Type of participants: Eligible patients were all adult trauma victims admitted to a participating hospital through the ED during a consecutive three-month period occurring between June and November 1989. Measurements: HIV-1 antibody testing was done using enzyme immunoassay confirmed by immunofluorescence assay. Equivocal results were confirmed by Western blot. Mann-Whitney U test, χ2 test, and multiple logistic regression were used where appropriate. Results: There were 2,264 patients with adequate blood samples for serologic testing. The seroprevalence rates for hospitals in groups 1, 2, and 3 were significantly different (χ2 = 8.44, P = .02): Group 1, 2.5% (19 of 756; 95% confidence interval [CI], 1.5% to 3.9%); group 2, 0.9% (10 of 1,078; CI, 0.5% to 1.7%); and group 3, 0.5% (two of 430; CI, 0.06% to 1.7%). Conclusion: This study suggests that local AIDS incidence rates do not necessarily predict the seroprevalence rates of injured patients who are admitted through local EDs.

Original languageEnglish (US)
Pages (from-to)969-972
Number of pages4
JournalAnnals of Emergency Medicine
Volume20
Issue number9
DOIs
StatePublished - 1991

Fingerprint

HIV Seroprevalence
HIV-1
Hospital Emergency Service
Acquired Immunodeficiency Syndrome
County Hospitals
Seroepidemiologic Studies
Incidence
HIV Antibodies
Confidence Intervals
Nonparametric Statistics
Immunoenzyme Techniques
Population Groups
Population
Fluorescent Antibody Technique
Logistic Models
Western Blotting
Wounds and Injuries

Keywords

  • HIV, seroprevalence

ASJC Scopus subject areas

  • Emergency Medicine

Cite this

The HIV-1 seroprevalence rate of injured patients admitted through California emergency departments. / Rhee, Kenneth J.; Albertson, Timothy E; Kizer, Kenneth W; Hughes, Michael J.; Ascher, Michael S.

In: Annals of Emergency Medicine, Vol. 20, No. 9, 1991, p. 969-972.

Research output: Contribution to journalArticle

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abstract = "Study objectives: To measure the HIV seroprevalence of injured emergency department patients in a number of California hospitals and to examine the relationship between ED seroprevalence and local AIDS incidence. Design: Prospective blinded testing for HIV-1 antibody was performed on routinely collected blood samples. Setting: Ten California hospitals; group 1 included three hospitals from counties of high AIDS incidence (more than 40 cases per 100,000 population), group 2 included three hospitals from counties of intermediate AIDS incidence (20 to 40 cases per 100,000 population); and group 3 included four hospitals from counties of low AIDS incidence (less than 20 cases per 100,000 population). Type of participants: Eligible patients were all adult trauma victims admitted to a participating hospital through the ED during a consecutive three-month period occurring between June and November 1989. Measurements: HIV-1 antibody testing was done using enzyme immunoassay confirmed by immunofluorescence assay. Equivocal results were confirmed by Western blot. Mann-Whitney U test, χ2 test, and multiple logistic regression were used where appropriate. Results: There were 2,264 patients with adequate blood samples for serologic testing. The seroprevalence rates for hospitals in groups 1, 2, and 3 were significantly different (χ2 = 8.44, P = .02): Group 1, 2.5{\%} (19 of 756; 95{\%} confidence interval [CI], 1.5{\%} to 3.9{\%}); group 2, 0.9{\%} (10 of 1,078; CI, 0.5{\%} to 1.7{\%}); and group 3, 0.5{\%} (two of 430; CI, 0.06{\%} to 1.7{\%}). Conclusion: This study suggests that local AIDS incidence rates do not necessarily predict the seroprevalence rates of injured patients who are admitted through local EDs.",
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AB - Study objectives: To measure the HIV seroprevalence of injured emergency department patients in a number of California hospitals and to examine the relationship between ED seroprevalence and local AIDS incidence. Design: Prospective blinded testing for HIV-1 antibody was performed on routinely collected blood samples. Setting: Ten California hospitals; group 1 included three hospitals from counties of high AIDS incidence (more than 40 cases per 100,000 population), group 2 included three hospitals from counties of intermediate AIDS incidence (20 to 40 cases per 100,000 population); and group 3 included four hospitals from counties of low AIDS incidence (less than 20 cases per 100,000 population). Type of participants: Eligible patients were all adult trauma victims admitted to a participating hospital through the ED during a consecutive three-month period occurring between June and November 1989. Measurements: HIV-1 antibody testing was done using enzyme immunoassay confirmed by immunofluorescence assay. Equivocal results were confirmed by Western blot. Mann-Whitney U test, χ2 test, and multiple logistic regression were used where appropriate. Results: There were 2,264 patients with adequate blood samples for serologic testing. The seroprevalence rates for hospitals in groups 1, 2, and 3 were significantly different (χ2 = 8.44, P = .02): Group 1, 2.5% (19 of 756; 95% confidence interval [CI], 1.5% to 3.9%); group 2, 0.9% (10 of 1,078; CI, 0.5% to 1.7%); and group 3, 0.5% (two of 430; CI, 0.06% to 1.7%). Conclusion: This study suggests that local AIDS incidence rates do not necessarily predict the seroprevalence rates of injured patients who are admitted through local EDs.

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