The hippocampus in aging and Alzheimer's disease

M. J. De Leon, A. Convit, S. DeSanti, J. Golomb, C. Tarshish, H. Rusinek, Matthew Bobinski, C. Ince, D. C. Miller, H. M. Wisniewski, A. E. George

Research output: Contribution to journalArticlepeer-review

45 Scopus citations


The role of imaging in the evaluation of neurodegenerative disorders is summarized. The primary role of imaging is to exclude potentially treatable disorders such as meningioma, extracerebral hematoma. Wernicke's disease, and hypothyroidism. Atrophic changes dominate in the hippocampal region on Alzheimer's disease versus the anterior, frontal, and temporal lobes in Pick's disease. Signal hypointensity in the putamen on T2-weighted spin-echo images favors poorly drug-responsive Parkinson's disease whereas putaminal hyperintensity is observed with Creutzfeld-Jacob, Wilson's, and Leigh's diseases. As our population ages, a thorough understanding of imaging findings in a geriatric population assumes an increasing importance.

Original languageEnglish (US)
Pages (from-to)1-17
Number of pages17
JournalNeuroimaging Clinics of North America
Issue number1
StatePublished - 1995
Externally publishedYes

ASJC Scopus subject areas

  • Clinical Neurology
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology


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