Abstract
Many findings have demonstrated that memories of past events are temporally organized. It is well known that the hippocampus is critical for such episodic memories, but, until recently, little was known about the temporal organization of mnemonic representations in the hippocampus. Recent developments in human and animal research have revealed important insights into the role of the hippocampus in learning and retrieving sequences of events. Here, we review these findings, including lesion and single-unit recording studies in rodents, functional magnetic resonance imaging studies in humans, and computational models that link findings from these studies to the anatomy of the hippocampal circuit. The findings converge toward the idea that the hippocampus is essential for learning sequences of events, allowing the brain to distinguish between memories for conceptually similar but temporally distinct episodes, and to associate representations of temporally contiguous, but otherwise unrelated experiences.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 93-110 |
| Number of pages | 18 |
| Journal | Annals of the New York Academy of Sciences |
| Volume | 1369 |
| Issue number | 1 |
| DOIs | |
| State | Published - Apr 1 2016 |
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Keywords
- Episodic
- Hippocampus
- Memory
- Sequence
- Time
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- History and Philosophy of Science
Cite this
The hippocampus : A special place for time. / Ranganath, Charan; Hsieh, Liang Tien.
In: Annals of the New York Academy of Sciences, Vol. 1369, No. 1, 01.04.2016, p. 93-110.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The hippocampus
T2 - A special place for time
AU - Ranganath, Charan
AU - Hsieh, Liang Tien
PY - 2016/4/1
Y1 - 2016/4/1
N2 - Many findings have demonstrated that memories of past events are temporally organized. It is well known that the hippocampus is critical for such episodic memories, but, until recently, little was known about the temporal organization of mnemonic representations in the hippocampus. Recent developments in human and animal research have revealed important insights into the role of the hippocampus in learning and retrieving sequences of events. Here, we review these findings, including lesion and single-unit recording studies in rodents, functional magnetic resonance imaging studies in humans, and computational models that link findings from these studies to the anatomy of the hippocampal circuit. The findings converge toward the idea that the hippocampus is essential for learning sequences of events, allowing the brain to distinguish between memories for conceptually similar but temporally distinct episodes, and to associate representations of temporally contiguous, but otherwise unrelated experiences.
AB - Many findings have demonstrated that memories of past events are temporally organized. It is well known that the hippocampus is critical for such episodic memories, but, until recently, little was known about the temporal organization of mnemonic representations in the hippocampus. Recent developments in human and animal research have revealed important insights into the role of the hippocampus in learning and retrieving sequences of events. Here, we review these findings, including lesion and single-unit recording studies in rodents, functional magnetic resonance imaging studies in humans, and computational models that link findings from these studies to the anatomy of the hippocampal circuit. The findings converge toward the idea that the hippocampus is essential for learning sequences of events, allowing the brain to distinguish between memories for conceptually similar but temporally distinct episodes, and to associate representations of temporally contiguous, but otherwise unrelated experiences.
KW - Episodic
KW - Hippocampus
KW - Memory
KW - Sequence
KW - Time
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UR - http://www.scopus.com/inward/citedby.url?scp=84963600308&partnerID=8YFLogxK
U2 - 10.1111/nyas.13043
DO - 10.1111/nyas.13043
M3 - Article
VL - 1369
SP - 93
EP - 110
JO - Annals of the New York Academy of Sciences
JF - Annals of the New York Academy of Sciences
SN - 0077-8923
IS - 1
ER -