The highly conserved defender against the death 1 (DAD1) gene maps to human chromosome 14q11-q12 and mouse chromosome 14 and has plant and nematode homologs

Suneel S. Apte, Marie Genevieve Mattei, Michael F Seldin, Bjorn R. Olsen

Research output: Contribution to journalArticlepeer-review

30 Scopus citations

Abstract

We have cloned the cDNA encoding the mouse DAD1 (defender against apoptotic cell death) protein. While showing an expected high homology with the previously cloned human and Xenopus DAD1-encoding cDNAs, this sequence has striking homology to partial cDNA sequences reported from O. sativa (rice) and C. elegans (nematode), suggesting the existence of plant and invertebrate homologs of this highly conserved gene. The human and mouse DAD1 genes map to chromosome 14q11-q12 and chromosome 14, respectively. This mapping data supports and extends the previously reported similarities between human chromosome 14q and mouse chromosome 14.

Original languageEnglish (US)
Pages (from-to)304-306
Number of pages3
JournalFEBS Letters
Volume363
Issue number3
DOIs
StatePublished - Apr 24 1995
Externally publishedYes

Keywords

  • Apoptosis
  • Cell death
  • Chromosome 14
  • DAD1
  • Programmed cell death

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Cell Biology
  • Genetics
  • Molecular Biology
  • Structural Biology

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