The Hepatic Stellate Cells (HSTCs) and Adipose-derived Mesenchymal Stem Cells (ASCs) Axis as a Potential Major Driver of Metabolic Syndrome – Novel Concept and Therapeutic Implications

Krzysztof Marycz, Katarzyna Kornicka-Garbowska, Larry Galuppo, Lynda Bourebaba

Research output: Contribution to journalArticlepeer-review

Abstract

Abstract: Herein, we would like to introduce a novel concept for the prevention and treatment of metabolic syndrome, which is based on molecular relationship between liver and adipose tissue. Particularly, we believe, that unravelling the molecular crosstalk between hepatokines and adipokines will allow to better understand the pathophysiology of metabolic diseases and allow to develop novel, effective therapeutic solutions against obesity and metabolic syndrome. Graphical Abstract: Inter-organ communication on the level of stem progenitor cells-hepatic stellate cells (HSTCs) and adipose-derived progenitors (ASCs) could represents a key mechanism involved in controlling glucose tolerance as well as insulin sensitivity. [Figure not available: see fulltext.].

Original languageEnglish (US)
JournalStem Cell Reviews and Reports
DOIs
StateAccepted/In press - 2021

Keywords

  • A-Reg
  • Adipokines
  • ASCs
  • Crosstalk
  • Hepatokines
  • HSTCs
  • Metabolic syndrome

ASJC Scopus subject areas

  • Cell Biology
  • Cancer Research

Fingerprint

Dive into the research topics of 'The Hepatic Stellate Cells (HSTCs) and Adipose-derived Mesenchymal Stem Cells (ASCs) Axis as a Potential Major Driver of Metabolic Syndrome – Novel Concept and Therapeutic Implications'. Together they form a unique fingerprint.

Cite this