Abstract
Haemophilus ducreyi is a Gram-negative bacterium that causes chancroid, a sexually transmitted genital ulcer disease. Different lipooligosaccharide (LOS) structures have been identified from H. ducreyi strain 35000, including those sialylated glycoforms. Surface LOS of H. ducreyi is considered an important virulence factor that is involved in ulcer formation, cell adhesion, and invasion of host tissue. Gene Hd0686 of H. ducreyi, designated lst (for lipooligosaccharide sialyltransferase), was identified to encode an α2,3-sialyltransferase that is important for the formation of sialylated LOS. Here, we show that Hd0053 of H. ducreyi genomic strain 35000HP, the third member of the glycosyltransferase family 80 (GT80), also encodes an α2,3-sialyltransferase that may be important for LOS sialylation.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 555-560 |
| Number of pages | 6 |
| Journal | Biochemical and Biophysical Research Communications |
| Volume | 361 |
| Issue number | 2 |
| DOIs | |
| State | Published - Sep 21 2007 |
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Keywords
- Bacterial sialyltransferase
- Glycosyltransferase
- GT80
- Haemophilus ducreyi
- Lipooligosaccharides
- Sialyltransferase
ASJC Scopus subject areas
- Biochemistry
- Biophysics
- Molecular Biology
Cite this
The Hd0053 gene of Haemophilus ducreyi encodes an α2,3-sialyltransferase. / Li, Yanhong; Sun, Mingchi; Huang, Shengshu; Yu, Hai; Chokhawala, Harshal A.; Thon, Vireak; Chen, Xi.
In: Biochemical and Biophysical Research Communications, Vol. 361, No. 2, 21.09.2007, p. 555-560.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The Hd0053 gene of Haemophilus ducreyi encodes an α2,3-sialyltransferase
AU - Li, Yanhong
AU - Sun, Mingchi
AU - Huang, Shengshu
AU - Yu, Hai
AU - Chokhawala, Harshal A.
AU - Thon, Vireak
AU - Chen, Xi
PY - 2007/9/21
Y1 - 2007/9/21
N2 - Haemophilus ducreyi is a Gram-negative bacterium that causes chancroid, a sexually transmitted genital ulcer disease. Different lipooligosaccharide (LOS) structures have been identified from H. ducreyi strain 35000, including those sialylated glycoforms. Surface LOS of H. ducreyi is considered an important virulence factor that is involved in ulcer formation, cell adhesion, and invasion of host tissue. Gene Hd0686 of H. ducreyi, designated lst (for lipooligosaccharide sialyltransferase), was identified to encode an α2,3-sialyltransferase that is important for the formation of sialylated LOS. Here, we show that Hd0053 of H. ducreyi genomic strain 35000HP, the third member of the glycosyltransferase family 80 (GT80), also encodes an α2,3-sialyltransferase that may be important for LOS sialylation.
AB - Haemophilus ducreyi is a Gram-negative bacterium that causes chancroid, a sexually transmitted genital ulcer disease. Different lipooligosaccharide (LOS) structures have been identified from H. ducreyi strain 35000, including those sialylated glycoforms. Surface LOS of H. ducreyi is considered an important virulence factor that is involved in ulcer formation, cell adhesion, and invasion of host tissue. Gene Hd0686 of H. ducreyi, designated lst (for lipooligosaccharide sialyltransferase), was identified to encode an α2,3-sialyltransferase that is important for the formation of sialylated LOS. Here, we show that Hd0053 of H. ducreyi genomic strain 35000HP, the third member of the glycosyltransferase family 80 (GT80), also encodes an α2,3-sialyltransferase that may be important for LOS sialylation.
KW - Bacterial sialyltransferase
KW - Glycosyltransferase
KW - GT80
KW - Haemophilus ducreyi
KW - Lipooligosaccharides
KW - Sialyltransferase
UR - http://www.scopus.com/inward/record.url?scp=34547539526&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34547539526&partnerID=8YFLogxK
U2 - 10.1016/j.bbrc.2007.07.063
DO - 10.1016/j.bbrc.2007.07.063
M3 - Article
C2 - 17662691
AN - SCOPUS:34547539526
VL - 361
SP - 555
EP - 560
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
SN - 0006-291X
IS - 2
ER -