The Hd0053 gene of Haemophilus ducreyi encodes an α2,3-sialyltransferase

Yanhong Li; Mingchi Sun; Shengshu Huang; Hai Yu; Harshal A. Chokhawala; Vireak Thon; Xi Chen

doi:10.1016/j.bbrc.2007.07.063

The Hd0053 gene of Haemophilus ducreyi encodes an α2,3-sialyltransferase

Yanhong Li, Mingchi Sun, Shengshu Huang, Hai Yu, Harshal A. Chokhawala, Vireak Thon, Xi Chen

Chemistry

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Haemophilus ducreyi is a Gram-negative bacterium that causes chancroid, a sexually transmitted genital ulcer disease. Different lipooligosaccharide (LOS) structures have been identified from H. ducreyi strain 35000, including those sialylated glycoforms. Surface LOS of H. ducreyi is considered an important virulence factor that is involved in ulcer formation, cell adhesion, and invasion of host tissue. Gene Hd0686 of H. ducreyi, designated lst (for lipooligosaccharide sialyltransferase), was identified to encode an α2,3-sialyltransferase that is important for the formation of sialylated LOS. Here, we show that Hd0053 of H. ducreyi genomic strain 35000HP, the third member of the glycosyltransferase family 80 (GT80), also encodes an α2,3-sialyltransferase that may be important for LOS sialylation.

Original language	English (US)
Pages (from-to)	555-560
Number of pages	6
Journal	Biochemical and Biophysical Research Communications
Volume	361
Issue number	2
DOIs	https://doi.org/10.1016/j.bbrc.2007.07.063
State	Published - Sep 21 2007

Keywords

Bacterial sialyltransferase
Glycosyltransferase
GT80
Haemophilus ducreyi
Lipooligosaccharides
Sialyltransferase

ASJC Scopus subject areas

Biochemistry
Biophysics
Molecular Biology

Access to Document

10.1016/j.bbrc.2007.07.063

Fingerprint Dive into the research topics of 'The Hd0053 gene of Haemophilus ducreyi encodes an α2,3-sialyltransferase'. Together they form a unique fingerprint.

Cite this

@article{03ba402424814664a629e93984a19c76,

title = "The Hd0053 gene of Haemophilus ducreyi encodes an α2,3-sialyltransferase",

abstract = "Haemophilus ducreyi is a Gram-negative bacterium that causes chancroid, a sexually transmitted genital ulcer disease. Different lipooligosaccharide (LOS) structures have been identified from H. ducreyi strain 35000, including those sialylated glycoforms. Surface LOS of H. ducreyi is considered an important virulence factor that is involved in ulcer formation, cell adhesion, and invasion of host tissue. Gene Hd0686 of H. ducreyi, designated lst (for lipooligosaccharide sialyltransferase), was identified to encode an α2,3-sialyltransferase that is important for the formation of sialylated LOS. Here, we show that Hd0053 of H. ducreyi genomic strain 35000HP, the third member of the glycosyltransferase family 80 (GT80), also encodes an α2,3-sialyltransferase that may be important for LOS sialylation.",

keywords = "Bacterial sialyltransferase, Glycosyltransferase, GT80, Haemophilus ducreyi, Lipooligosaccharides, Sialyltransferase",

author = "Yanhong Li and Mingchi Sun and Shengshu Huang and Hai Yu and Chokhawala, {Harshal A.} and Vireak Thon and Xi Chen",

year = "2007",

month = sep,

day = "21",

doi = "10.1016/j.bbrc.2007.07.063",

language = "English (US)",

volume = "361",

pages = "555--560",

journal = "Biochemical and Biophysical Research Communications",

issn = "0006-291X",

publisher = "Academic Press Inc.",

number = "2",

}

TY - JOUR

T1 - The Hd0053 gene of Haemophilus ducreyi encodes an α2,3-sialyltransferase

AU - Li, Yanhong

AU - Sun, Mingchi

AU - Huang, Shengshu

AU - Yu, Hai

AU - Chokhawala, Harshal A.

AU - Thon, Vireak

AU - Chen, Xi

PY - 2007/9/21

Y1 - 2007/9/21

N2 - Haemophilus ducreyi is a Gram-negative bacterium that causes chancroid, a sexually transmitted genital ulcer disease. Different lipooligosaccharide (LOS) structures have been identified from H. ducreyi strain 35000, including those sialylated glycoforms. Surface LOS of H. ducreyi is considered an important virulence factor that is involved in ulcer formation, cell adhesion, and invasion of host tissue. Gene Hd0686 of H. ducreyi, designated lst (for lipooligosaccharide sialyltransferase), was identified to encode an α2,3-sialyltransferase that is important for the formation of sialylated LOS. Here, we show that Hd0053 of H. ducreyi genomic strain 35000HP, the third member of the glycosyltransferase family 80 (GT80), also encodes an α2,3-sialyltransferase that may be important for LOS sialylation.

AB - Haemophilus ducreyi is a Gram-negative bacterium that causes chancroid, a sexually transmitted genital ulcer disease. Different lipooligosaccharide (LOS) structures have been identified from H. ducreyi strain 35000, including those sialylated glycoforms. Surface LOS of H. ducreyi is considered an important virulence factor that is involved in ulcer formation, cell adhesion, and invasion of host tissue. Gene Hd0686 of H. ducreyi, designated lst (for lipooligosaccharide sialyltransferase), was identified to encode an α2,3-sialyltransferase that is important for the formation of sialylated LOS. Here, we show that Hd0053 of H. ducreyi genomic strain 35000HP, the third member of the glycosyltransferase family 80 (GT80), also encodes an α2,3-sialyltransferase that may be important for LOS sialylation.

KW - Bacterial sialyltransferase

KW - Glycosyltransferase

KW - GT80

KW - Haemophilus ducreyi

KW - Lipooligosaccharides

KW - Sialyltransferase

UR - http://www.scopus.com/inward/record.url?scp=34547539526&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34547539526&partnerID=8YFLogxK

U2 - 10.1016/j.bbrc.2007.07.063

DO - 10.1016/j.bbrc.2007.07.063

M3 - Article

C2 - 17662691

AN - SCOPUS:34547539526

VL - 361

SP - 555

EP - 560

JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

SN - 0006-291X

IS - 2

ER -