The Hd0053 gene of Haemophilus ducreyi encodes an α2,3-sialyltransferase

Yanhong Li, Mingchi Sun, Shengshu Huang, Hai Yu, Harshal A. Chokhawala, Vireak Thon, Xi Chen

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Haemophilus ducreyi is a Gram-negative bacterium that causes chancroid, a sexually transmitted genital ulcer disease. Different lipooligosaccharide (LOS) structures have been identified from H. ducreyi strain 35000, including those sialylated glycoforms. Surface LOS of H. ducreyi is considered an important virulence factor that is involved in ulcer formation, cell adhesion, and invasion of host tissue. Gene Hd0686 of H. ducreyi, designated lst (for lipooligosaccharide sialyltransferase), was identified to encode an α2,3-sialyltransferase that is important for the formation of sialylated LOS. Here, we show that Hd0053 of H. ducreyi genomic strain 35000HP, the third member of the glycosyltransferase family 80 (GT80), also encodes an α2,3-sialyltransferase that may be important for LOS sialylation.

Original languageEnglish (US)
Pages (from-to)555-560
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume361
Issue number2
DOIs
StatePublished - Sep 21 2007

Keywords

  • Bacterial sialyltransferase
  • Glycosyltransferase
  • GT80
  • Haemophilus ducreyi
  • Lipooligosaccharides
  • Sialyltransferase

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

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