Abstract
Gastrointestinal (GI) symptoms are a common comorbidity in patients with autism spectrum disorder (ASD), but the underlying mechanisms are unknown. Many studies have shown alterations in the composition of the fecal flora and metabolic products of the gut microbiome in patients with ASD. The gut microbiota influences brain development and behaviors through the neuroendocrine, neuroimmune and autonomic nervous systems. In addition, an abnormal gut microbiota is associated with several diseases, such as inflammatory bowel disease (IBD), ASD and mood disorders. Here, we review the bidirectional interactions between the central nervous systemand the gastrointestinal tract (brain-gut axis) and the role of the gut microbiota in the central nervous system (CNS) and ASD. Microbiome-mediated therapies might be a safe and effective treatment for ASD.
| Original language | English (US) |
|---|---|
| Article number | 120 |
| Journal | Frontiers in Cellular Neuroscience |
| Volume | 11 |
| DOIs | |
| State | Published - Apr 28 2017 |
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Keywords
- Autism spectrum disorder (ASD)
- Brain-gut axis
- Fecal microbiota transplantation (FMT)
- Gut microbiota
- Probiotics
ASJC Scopus subject areas
- Cellular and Molecular Neuroscience
Cite this
The gut microbiota and autism spectrum disorders. / Li, Qinrui; Han, Ying; Dy, Angel Belle C.; Hagerman, Randi J.
In: Frontiers in Cellular Neuroscience, Vol. 11, 120, 28.04.2017.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - The gut microbiota and autism spectrum disorders
AU - Li, Qinrui
AU - Han, Ying
AU - Dy, Angel Belle C.
AU - Hagerman, Randi J
PY - 2017/4/28
Y1 - 2017/4/28
N2 - Gastrointestinal (GI) symptoms are a common comorbidity in patients with autism spectrum disorder (ASD), but the underlying mechanisms are unknown. Many studies have shown alterations in the composition of the fecal flora and metabolic products of the gut microbiome in patients with ASD. The gut microbiota influences brain development and behaviors through the neuroendocrine, neuroimmune and autonomic nervous systems. In addition, an abnormal gut microbiota is associated with several diseases, such as inflammatory bowel disease (IBD), ASD and mood disorders. Here, we review the bidirectional interactions between the central nervous systemand the gastrointestinal tract (brain-gut axis) and the role of the gut microbiota in the central nervous system (CNS) and ASD. Microbiome-mediated therapies might be a safe and effective treatment for ASD.
AB - Gastrointestinal (GI) symptoms are a common comorbidity in patients with autism spectrum disorder (ASD), but the underlying mechanisms are unknown. Many studies have shown alterations in the composition of the fecal flora and metabolic products of the gut microbiome in patients with ASD. The gut microbiota influences brain development and behaviors through the neuroendocrine, neuroimmune and autonomic nervous systems. In addition, an abnormal gut microbiota is associated with several diseases, such as inflammatory bowel disease (IBD), ASD and mood disorders. Here, we review the bidirectional interactions between the central nervous systemand the gastrointestinal tract (brain-gut axis) and the role of the gut microbiota in the central nervous system (CNS) and ASD. Microbiome-mediated therapies might be a safe and effective treatment for ASD.
KW - Autism spectrum disorder (ASD)
KW - Brain-gut axis
KW - Fecal microbiota transplantation (FMT)
KW - Gut microbiota
KW - Probiotics
UR - http://www.scopus.com/inward/record.url?scp=85019235186&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85019235186&partnerID=8YFLogxK
U2 - 10.3389/fncel.2017.00120
DO - 10.3389/fncel.2017.00120
M3 - Review article
AN - SCOPUS:85019235186
VL - 11
JO - Frontiers in Cellular Neuroscience
JF - Frontiers in Cellular Neuroscience
SN - 1662-5102
M1 - 120
ER -