The gut microbiota and autism spectrum disorders

Qinrui Li, Ying Han, Angel Belle C. Dy, Randi J Hagerman

Research output: Contribution to journalReview article

99 Citations (Scopus)

Abstract

Gastrointestinal (GI) symptoms are a common comorbidity in patients with autism spectrum disorder (ASD), but the underlying mechanisms are unknown. Many studies have shown alterations in the composition of the fecal flora and metabolic products of the gut microbiome in patients with ASD. The gut microbiota influences brain development and behaviors through the neuroendocrine, neuroimmune and autonomic nervous systems. In addition, an abnormal gut microbiota is associated with several diseases, such as inflammatory bowel disease (IBD), ASD and mood disorders. Here, we review the bidirectional interactions between the central nervous systemand the gastrointestinal tract (brain-gut axis) and the role of the gut microbiota in the central nervous system (CNS) and ASD. Microbiome-mediated therapies might be a safe and effective treatment for ASD.

Original languageEnglish (US)
Article number120
JournalFrontiers in Cellular Neuroscience
Volume11
DOIs
StatePublished - Apr 28 2017

Fingerprint

Microbiota
Autonomic Nervous System
Brain
Mood Disorders
Inflammatory Bowel Diseases
Gastrointestinal Tract
Comorbidity
Central Nervous System
Autism Spectrum Disorder
Gastrointestinal Microbiome
Therapeutics

Keywords

  • Autism spectrum disorder (ASD)
  • Brain-gut axis
  • Fecal microbiota transplantation (FMT)
  • Gut microbiota
  • Probiotics

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience

Cite this

The gut microbiota and autism spectrum disorders. / Li, Qinrui; Han, Ying; Dy, Angel Belle C.; Hagerman, Randi J.

In: Frontiers in Cellular Neuroscience, Vol. 11, 120, 28.04.2017.

Research output: Contribution to journalReview article

Li, Qinrui ; Han, Ying ; Dy, Angel Belle C. ; Hagerman, Randi J. / The gut microbiota and autism spectrum disorders. In: Frontiers in Cellular Neuroscience. 2017 ; Vol. 11.
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