The gut-brain axis in childhood developmental disorders: Viruses and vaccines

Andrew J. Wakefield, Paul Ashwood, Iain Collins

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

This chapter is written from the perspective of the gastroenterologist. It seeks to summarize the evidence that viral exposure leading to an initial extracranial infection may be associated, indirectly or directly, with neuropsychiatric pathology. The focus is largely upon autism and gastrointestinal (GI) inflammation although recent reports suggest that the GI findings may be relevant to a broader spectrum of developmental disorders.1,2 Autism, like hepatic encephalopathy, is a behavioral syndrome that reflects cerebral dysfunction. Both may be the final common expression of a variety of different initiating insults, including primary genetic disorders, infection, toxic injury, and autoimmune disease. Can autism be caused by a viral infection and, if so, what is the pathogenetic chain of events that links exposure to neuropathology?

Original languageEnglish (US)
Title of host publicationNeuropsychiatric Disorders and Infection
PublisherCRC Press
Pages198-206
Number of pages9
ISBN (Electronic)9780203007648
ISBN (Print)1841845205, 9781841845203
StatePublished - Jan 1 2005

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Wakefield, A. J., Ashwood, P., & Collins, I. (2005). The gut-brain axis in childhood developmental disorders: Viruses and vaccines. In Neuropsychiatric Disorders and Infection (pp. 198-206). CRC Press.