The growth hormone responses to L-dopa and TRH in acromegaly

I. Jialal, C. Naidoo, B. C. Nathoo, M. C. Rajput, S. M. Joubert

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


The GH responses to TRH and L-dopa were investigated in 14 Indian and African patients with untreated acromegaly. A positive response to L-dopa (>50% change from basal) was obtained in 6 of the 14 patients tested while a positive response to TRH (>100% change from basal) was found in 5 of 12 patients tested. While 9 patients responded to at least one agent, only 2 had a positive response to both agents. Positive responders appeared to be hyper-prolactinemic and have evidence of abnormal glucose tolerance as compared to nonresponders.

Original languageEnglish (US)
Pages (from-to)235-237
Number of pages3
JournalJournal of Endocrinological Investigation
Issue number3
StatePublished - 1984
Externally publishedYes

ASJC Scopus subject areas

  • Endocrinology


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