Abstract
Systemic lupus erythematosus (SLE) is a systemic autoimmune disease with manifold clinical manifestations and immunological abnormalities, affecting primarily women. Although accurate current data on its incidence and prevalence are largely lacking, there are numerous indications that SLE is far less common in Europeans and their descendants compared to all other ethnicities. The clinical manifestations of the disease show geographic or ethnic variation, generally being less severe in patients of European ancestry than in African, Asian, certain "Hispanic" or mestizo, and various indigenous populations. In particular, renal involvement is far more common in non-European patients. Genetic as well as environmental, sociodemographic and sociocultural factors are likely to contribute to the differences in the incidence and clinical expression of SLE.
| Original language | English (US) |
|---|---|
| Journal | Autoimmunity Reviews |
| Volume | 9 |
| Issue number | 5 |
| DOIs | |
| State | Published - Mar 2010 |
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ASJC Scopus subject areas
- Immunology
- Immunology and Allergy
Cite this
The geoepidemiology of systemic lupus erythematosus. / Borchers, Andrea T.; Naguwa, Stanley M; Shoenfeld, Yehuda; Gershwin, M. Eric.
In: Autoimmunity Reviews, Vol. 9, No. 5, 03.2010.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The geoepidemiology of systemic lupus erythematosus
AU - Borchers, Andrea T.
AU - Naguwa, Stanley M
AU - Shoenfeld, Yehuda
AU - Gershwin, M. Eric
PY - 2010/3
Y1 - 2010/3
N2 - Systemic lupus erythematosus (SLE) is a systemic autoimmune disease with manifold clinical manifestations and immunological abnormalities, affecting primarily women. Although accurate current data on its incidence and prevalence are largely lacking, there are numerous indications that SLE is far less common in Europeans and their descendants compared to all other ethnicities. The clinical manifestations of the disease show geographic or ethnic variation, generally being less severe in patients of European ancestry than in African, Asian, certain "Hispanic" or mestizo, and various indigenous populations. In particular, renal involvement is far more common in non-European patients. Genetic as well as environmental, sociodemographic and sociocultural factors are likely to contribute to the differences in the incidence and clinical expression of SLE.
AB - Systemic lupus erythematosus (SLE) is a systemic autoimmune disease with manifold clinical manifestations and immunological abnormalities, affecting primarily women. Although accurate current data on its incidence and prevalence are largely lacking, there are numerous indications that SLE is far less common in Europeans and their descendants compared to all other ethnicities. The clinical manifestations of the disease show geographic or ethnic variation, generally being less severe in patients of European ancestry than in African, Asian, certain "Hispanic" or mestizo, and various indigenous populations. In particular, renal involvement is far more common in non-European patients. Genetic as well as environmental, sociodemographic and sociocultural factors are likely to contribute to the differences in the incidence and clinical expression of SLE.
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U2 - 10.1016/j.autrev.2009.12.008
DO - 10.1016/j.autrev.2009.12.008
M3 - Article
VL - 9
JO - Autoimmunity Reviews
JF - Autoimmunity Reviews
SN - 1568-9972
IS - 5
ER -