The genome sequence of taurine cattle

A window to ruminant biology and evolution

Christine G. Elsik, Ross L. Tellam, Kim C. Worley, Richard A. Gibbs, Donna M. Muzny, George M. Weinstock, David L. Adelson, Evan E. Eichler, Laura Elnitski, Roderic Guigó, Debora L. Hamernik, Steve M. Kappes, Harris A. Lewin, David J. Lynn, Frank W. Nicholas, Alexandre Reymond, Monique Rijnkels, Loren C. Skow, Evgeny M. Zdobnov, Lawrence Schook & 288 others James Womack, Tyler Alioto, Stylianos E. Antonarakis, Alex Astashyn, Charles E. Chappie, Hsiu Chuan Chen, Jacqueline Chrast, Francisco Câmara, Olga Ermolaeva, Charlotte N. Henrichsen, Wratko Hlavina, Yuri Kapustin, Boris Kiryutin, Paul Kitts, Felix Kokocinski, Melissa Landrum, Donna Maglott, Kim Pruitt, Victor Sapojnikov, Stephen M. Searle, Victor Solovyev, Alexandre Souvorov, Catherine Ucla, Carine Wyss, Juan M. Anzola, Daniel Gerlach, Eran Elhaik, Dan Graur, Justin T. Reese, Robert C. Edgar, John C. McEwan, Gemma M. Payne, Joy M. Raison, Thomas Junier, Evgenia V. Kriventseva, Eduardo Eyras, Mireya Plass, Ravikiran Donthu, Denis M. Larkin, James Reecy, Mary Q. Yang, Lin Chen, Ze Cheng, Carol G. Chitko-McKown, George E. Liu, Lakshmi K. Matukumalli, Jiuzhou Song, Bin Zhu, Daniel G. Bradley, Fiona S L Brinkman, Lilian P L Lau, Matthew D. Whiteside, Angela Walker, Thomas T. Wheeler, Theresa Casey, J. Bruce German, Danielle G. Lemay, Nauman J. Maqbool, Adrian J. Molenaar, Seongwon Seo, Paul Stothard, Cynthia L. Baldwin, Rebecca Baxter, Candice L. Brinkmeyer-Larigford, Wendy C. Brown, Christopher P. Childers, Timothy Connelley, Shirley A. Ellis, Krista Fritz, Elizabeth J. Glass, Carolyn T A Herzig, Antti Livanainen, Kevin K. Lahmers, Anna K. Bennett, C. Michael Dickens, James G R Gilbert, Darren E. Hagen, Hanni Salih, Jan Aerts, Alexandre R. Caetano, Brian Dalrymple, Jose Fernando Garcia, Clare A. Gill, Stefan G. Hiendleder, Erdogan Memili, Diane Spurlock, John L. Williams, Lee Alexander, Michael J. Brownstein, Leluo Guan, Robert A. Holt, Steven J M Jones, Marco A. Marra, Richard Moore, Stephen S. Moore, Andy Roberts, Masaaki Taniguchi, Richard C. Waterman, Joseph Chacko, Mimi M. Chandrabose, Andy Cree, Marvin Diep Dao, Huyen H. Dinh, Ramatu Ayiesha Gabisi, Sandra Hines, Jennifer Hume, Shalini N. Jhangiani, Vandita Joshi, Christie L. Kovar, Lora R. Lewis, Yin Shin Liu, John Lopez, Margaret B. Morgan, Ngoc Bich Nguyen, Geoffrey O. Okwuonu, San Juana Ruiz, Jireh Santibanez, Rita A. Wright, Christian Buhay, Yan Ding, Shannon Dugan-Rocha, Judith Herdandez, Michael Holder, Aniko Sabo, Amy Egan, Jason Goodell, Katarzyna Wilczek-Boney, Gerald R. Fowler, Matthew Edward Hitchens, Ryan J. Lozado, Charles Moen, David Steffen, James T. Warren, Jingkun Zhang, Readman Chiu, Jacqueline E. Schein, K. James Durbin, Paul Havlak, Huaiyang Jiang, Yue Liu, Xiang Qin, Yanru Ren, Yufeng Shen, Henry Song, Stephanie Nicole Bell, Clay Davis, Angela Jolivet Johnson, Sandra Lee, Lynne V. Nazareth, Bella Mayurkumar Patel, Ling Ling Pu, Selina Vattathil, Rex Lee Williams, Stacey Curry, Cerissa Hamilton, Erica Sodergren, David A. Wheeler, Wes Barris, Gary L. Bennett, Andre Eggen, Ronnie D. Green, Gregory P. Harhay, Matthew Hobbs, Oliver Jann, John W. Keele, Matthew P. Kent, Sigbjam Lien, Stephanie D. McKay, Sean McWilliam, Abhirami Ratnakumar, Robert D. Schnabel, Timothy Smith, Warren M. Snelling, Tad S. Sonstegard, Roger T. Stone, Yoshikazu Sugimoto, Akiko Takasuga, Jeremy F. Taylor, Curtis P. Van Tassell, Michael D. MacNeil, Antonio R R Abatepaulo, Colette A. Abbey, Virpi Ahola, Lassudara G. Almeida, Ariel F. Amadio, Elen Anatriello, Suria M. Bahadue, Fernando H. Biase, Clayton R. Boldt, Jeffery A. Carroll, Wanessa A. Carvalho, Eliane P. Cervelatti, Elsa Chacko, Jennifer E. Chapin, Ye Cheng, Jungwoo Choi, Adam J. Colley, Tatiana A. DeCampos, Marcos De Donato, Isabel K F De Miranda Santos, Carlo J F De Oliveira, Heather Deobald, Eve Devinoy, Kaitlin E. Donohue, Peter Dove, Annett Eberlein, Carolyn J. Fitzsimmons, Alessandra M. Franzin, Gustavo R. Garcia, Sem Genini, Cody J. Gladney, Jason R. Grant, Marion L. Greaser, Jonathan A. Green, Darryl L. Hadsell, Hatam A. Hakimov, Rob Halgren, Jennifer L. Harrow, Elizabeth A. Hart, Nicola Hastings, Marta Hernandez, Zhi Liang Hu, Antti Iivanainen, Aaron Ingham, Terhi Iso-Touru, Catherine Jamis, Kirsty Jensen, Dimos Kapetis, Tovah Kerr, Sari S. Khalil, Hasan Khatib, Davood Kolbehdari, Cham G. Kumar, Dinesh Kumar, Richard Leach, Justin C M Lee, Changxi Li, Krystin M. Logan, Roberto Malinverni, Elisa Marques, William F. Martin, Natalia F. Martins, Sandra R. Maruyama, Raffaele Mazza, Kim L. McLean, Juan F. Medrano, Barbara T. Moreno, Daniela D. More, Carl T. Muntean, Hari P. Nandakumar, Marcelo F G Nogueira, Ingrid Olsaker, Sameer D. Pant, Francesca Panzitta, Rosemeire C P Pastor, Mario A. Poli, Nathan Poslusny, Satyanarayana Rachagani, Shoba Ranganathan, Andrej Razpet, Penny K. Riggs, Gonzalo Rincón, Nelida Rodriguez-Osorio, Sandra L. Rodriguez-Zas, Natasha E. Romero, Anne Rosenwald, Lillian Sando, Sheila M. Schmutz, Libing Shen, Laura Sherman, Bruce R. Southey, Ylva Strandberg Lutzow, Jonathan V. Sweedler, Imke Tammen, Bhanu Prakash V L Telugu, Jennifer M. Urbanski, Yuri T. Utsunomiya, Chris P. Verschoor, Ashley J. Waardenberg, Zhiquan Wang, Robert Ward, Rosemarie WeiKard, Thomas H. Welsh, Stephen N. White, Laurens G. Wilming, Kris R. Wunderlich, Jianqi Yang, Feng Qi Zhao

Research output: Contribution to journalArticle

734 Citations (Scopus)

Abstract

To understand the biology and evolution of ruminants, the cattle genome was sequenced to about sevenfold coverage. The cattle genome contains a minimum of 22,000 genes, with a core set of 14,345 orthologs shared among seven mammalian species of which 1217 are absent or undetected in noneutherian (marsupial or monotreme) genomes. Cattle-specific evolutionary breakpoint regions in chromosomes have a higher density of segmental duplications, enrichment of repetitive elements, and species-specific variations in genes associated with lactation and immune responsiveness. Genes involved in metabolism are generally highly conserved, although five metabolic genes are deleted or extensively diverged from their human orthologs. The cattle genome sequence thu5 provides a resource for understanding mammalian evolution and accelerating livestock genetic improvement for milk and meat production.

Original languageEnglish (US)
Pages (from-to)522-528
Number of pages7
JournalScience
Volume324
Issue number5926
DOIs
StatePublished - Apr 24 2009

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Taurine
Ruminants
Genome
Genes
Genomic Segmental Duplications
Marsupialia
Livestock
Lactation
Meat
Milk
Chromosomes

ASJC Scopus subject areas

  • General

Cite this

Elsik, C. G., Tellam, R. L., Worley, K. C., Gibbs, R. A., Muzny, D. M., Weinstock, G. M., ... Zhao, F. Q. (2009). The genome sequence of taurine cattle: A window to ruminant biology and evolution. Science, 324(5926), 522-528. https://doi.org/10.1126/science.1169588

The genome sequence of taurine cattle : A window to ruminant biology and evolution. / Elsik, Christine G.; Tellam, Ross L.; Worley, Kim C.; Gibbs, Richard A.; Muzny, Donna M.; Weinstock, George M.; Adelson, David L.; Eichler, Evan E.; Elnitski, Laura; Guigó, Roderic; Hamernik, Debora L.; Kappes, Steve M.; Lewin, Harris A.; Lynn, David J.; Nicholas, Frank W.; Reymond, Alexandre; Rijnkels, Monique; Skow, Loren C.; Zdobnov, Evgeny M.; Schook, Lawrence; Womack, James; Alioto, Tyler; Antonarakis, Stylianos E.; Astashyn, Alex; Chappie, Charles E.; Chen, Hsiu Chuan; Chrast, Jacqueline; Câmara, Francisco; Ermolaeva, Olga; Henrichsen, Charlotte N.; Hlavina, Wratko; Kapustin, Yuri; Kiryutin, Boris; Kitts, Paul; Kokocinski, Felix; Landrum, Melissa; Maglott, Donna; Pruitt, Kim; Sapojnikov, Victor; Searle, Stephen M.; Solovyev, Victor; Souvorov, Alexandre; Ucla, Catherine; Wyss, Carine; Anzola, Juan M.; Gerlach, Daniel; Elhaik, Eran; Graur, Dan; Reese, Justin T.; Edgar, Robert C.; McEwan, John C.; Payne, Gemma M.; Raison, Joy M.; Junier, Thomas; Kriventseva, Evgenia V.; Eyras, Eduardo; Plass, Mireya; Donthu, Ravikiran; Larkin, Denis M.; Reecy, James; Yang, Mary Q.; Chen, Lin; Cheng, Ze; Chitko-McKown, Carol G.; Liu, George E.; Matukumalli, Lakshmi K.; Song, Jiuzhou; Zhu, Bin; Bradley, Daniel G.; Brinkman, Fiona S L; Lau, Lilian P L; Whiteside, Matthew D.; Walker, Angela; Wheeler, Thomas T.; Casey, Theresa; German, J. Bruce; Lemay, Danielle G.; Maqbool, Nauman J.; Molenaar, Adrian J.; Seo, Seongwon; Stothard, Paul; Baldwin, Cynthia L.; Baxter, Rebecca; Brinkmeyer-Larigford, Candice L.; Brown, Wendy C.; Childers, Christopher P.; Connelley, Timothy; Ellis, Shirley A.; Fritz, Krista; Glass, Elizabeth J.; Herzig, Carolyn T A; Livanainen, Antti; Lahmers, Kevin K.; Bennett, Anna K.; Dickens, C. Michael; Gilbert, James G R; Hagen, Darren E.; Salih, Hanni; Aerts, Jan; Caetano, Alexandre R.; Dalrymple, Brian; Garcia, Jose Fernando; Gill, Clare A.; Hiendleder, Stefan G.; Memili, Erdogan; Spurlock, Diane; Williams, John L.; Alexander, Lee; Brownstein, Michael J.; Guan, Leluo; Holt, Robert A.; Jones, Steven J M; Marra, Marco A.; Moore, Richard; Moore, Stephen S.; Roberts, Andy; Taniguchi, Masaaki; Waterman, Richard C.; Chacko, Joseph; Chandrabose, Mimi M.; Cree, Andy; Dao, Marvin Diep; Dinh, Huyen H.; Gabisi, Ramatu Ayiesha; Hines, Sandra; Hume, Jennifer; Jhangiani, Shalini N.; Joshi, Vandita; Kovar, Christie L.; Lewis, Lora R.; Liu, Yin Shin; Lopez, John; Morgan, Margaret B.; Nguyen, Ngoc Bich; Okwuonu, Geoffrey O.; Ruiz, San Juana; Santibanez, Jireh; Wright, Rita A.; Buhay, Christian; Ding, Yan; Dugan-Rocha, Shannon; Herdandez, Judith; Holder, Michael; Sabo, Aniko; Egan, Amy; Goodell, Jason; Wilczek-Boney, Katarzyna; Fowler, Gerald R.; Hitchens, Matthew Edward; Lozado, Ryan J.; Moen, Charles; Steffen, David; Warren, James T.; Zhang, Jingkun; Chiu, Readman; Schein, Jacqueline E.; Durbin, K. James; Havlak, Paul; Jiang, Huaiyang; Liu, Yue; Qin, Xiang; Ren, Yanru; Shen, Yufeng; Song, Henry; Bell, Stephanie Nicole; Davis, Clay; Johnson, Angela Jolivet; Lee, Sandra; Nazareth, Lynne V.; Patel, Bella Mayurkumar; Pu, Ling Ling; Vattathil, Selina; Williams, Rex Lee; Curry, Stacey; Hamilton, Cerissa; Sodergren, Erica; Wheeler, David A.; Barris, Wes; Bennett, Gary L.; Eggen, Andre; Green, Ronnie D.; Harhay, Gregory P.; Hobbs, Matthew; Jann, Oliver; Keele, John W.; Kent, Matthew P.; Lien, Sigbjam; McKay, Stephanie D.; McWilliam, Sean; Ratnakumar, Abhirami; Schnabel, Robert D.; Smith, Timothy; Snelling, Warren M.; Sonstegard, Tad S.; Stone, Roger T.; Sugimoto, Yoshikazu; Takasuga, Akiko; Taylor, Jeremy F.; Van Tassell, Curtis P.; MacNeil, Michael D.; Abatepaulo, Antonio R R; Abbey, Colette A.; Ahola, Virpi; Almeida, Lassudara G.; Amadio, Ariel F.; Anatriello, Elen; Bahadue, Suria M.; Biase, Fernando H.; Boldt, Clayton R.; Carroll, Jeffery A.; Carvalho, Wanessa A.; Cervelatti, Eliane P.; Chacko, Elsa; Chapin, Jennifer E.; Cheng, Ye; Choi, Jungwoo; Colley, Adam J.; DeCampos, Tatiana A.; De Donato, Marcos; De Miranda Santos, Isabel K F; De Oliveira, Carlo J F; Deobald, Heather; Devinoy, Eve; Donohue, Kaitlin E.; Dove, Peter; Eberlein, Annett; Fitzsimmons, Carolyn J.; Franzin, Alessandra M.; Garcia, Gustavo R.; Genini, Sem; Gladney, Cody J.; Grant, Jason R.; Greaser, Marion L.; Green, Jonathan A.; Hadsell, Darryl L.; Hakimov, Hatam A.; Halgren, Rob; Harrow, Jennifer L.; Hart, Elizabeth A.; Hastings, Nicola; Hernandez, Marta; Hu, Zhi Liang; Iivanainen, Antti; Ingham, Aaron; Iso-Touru, Terhi; Jamis, Catherine; Jensen, Kirsty; Kapetis, Dimos; Kerr, Tovah; Khalil, Sari S.; Khatib, Hasan; Kolbehdari, Davood; Kumar, Cham G.; Kumar, Dinesh; Leach, Richard; Lee, Justin C M; Li, Changxi; Logan, Krystin M.; Malinverni, Roberto; Marques, Elisa; Martin, William F.; Martins, Natalia F.; Maruyama, Sandra R.; Mazza, Raffaele; McLean, Kim L.; Medrano, Juan F.; Moreno, Barbara T.; More, Daniela D.; Muntean, Carl T.; Nandakumar, Hari P.; Nogueira, Marcelo F G; Olsaker, Ingrid; Pant, Sameer D.; Panzitta, Francesca; Pastor, Rosemeire C P; Poli, Mario A.; Poslusny, Nathan; Rachagani, Satyanarayana; Ranganathan, Shoba; Razpet, Andrej; Riggs, Penny K.; Rincón, Gonzalo; Rodriguez-Osorio, Nelida; Rodriguez-Zas, Sandra L.; Romero, Natasha E.; Rosenwald, Anne; Sando, Lillian; Schmutz, Sheila M.; Shen, Libing; Sherman, Laura; Southey, Bruce R.; Lutzow, Ylva Strandberg; Sweedler, Jonathan V.; Tammen, Imke; Telugu, Bhanu Prakash V L; Urbanski, Jennifer M.; Utsunomiya, Yuri T.; Verschoor, Chris P.; Waardenberg, Ashley J.; Wang, Zhiquan; Ward, Robert; WeiKard, Rosemarie; Welsh, Thomas H.; White, Stephen N.; Wilming, Laurens G.; Wunderlich, Kris R.; Yang, Jianqi; Zhao, Feng Qi.

In: Science, Vol. 324, No. 5926, 24.04.2009, p. 522-528.

Research output: Contribution to journalArticle

Elsik, CG, Tellam, RL, Worley, KC, Gibbs, RA, Muzny, DM, Weinstock, GM, Adelson, DL, Eichler, EE, Elnitski, L, Guigó, R, Hamernik, DL, Kappes, SM, Lewin, HA, Lynn, DJ, Nicholas, FW, Reymond, A, Rijnkels, M, Skow, LC, Zdobnov, EM, Schook, L, Womack, J, Alioto, T, Antonarakis, SE, Astashyn, A, Chappie, CE, Chen, HC, Chrast, J, Câmara, F, Ermolaeva, O, Henrichsen, CN, Hlavina, W, Kapustin, Y, Kiryutin, B, Kitts, P, Kokocinski, F, Landrum, M, Maglott, D, Pruitt, K, Sapojnikov, V, Searle, SM, Solovyev, V, Souvorov, A, Ucla, C, Wyss, C, Anzola, JM, Gerlach, D, Elhaik, E, Graur, D, Reese, JT, Edgar, RC, McEwan, JC, Payne, GM, Raison, JM, Junier, T, Kriventseva, EV, Eyras, E, Plass, M, Donthu, R, Larkin, DM, Reecy, J, Yang, MQ, Chen, L, Cheng, Z, Chitko-McKown, CG, Liu, GE, Matukumalli, LK, Song, J, Zhu, B, Bradley, DG, Brinkman, FSL, Lau, LPL, Whiteside, MD, Walker, A, Wheeler, TT, Casey, T, German, JB, Lemay, DG, Maqbool, NJ, Molenaar, AJ, Seo, S, Stothard, P, Baldwin, CL, Baxter, R, Brinkmeyer-Larigford, CL, Brown, WC, Childers, CP, Connelley, T, Ellis, SA, Fritz, K, Glass, EJ, Herzig, CTA, Livanainen, A, Lahmers, KK, Bennett, AK, Dickens, CM, Gilbert, JGR, Hagen, DE, Salih, H, Aerts, J, Caetano, AR, Dalrymple, B, Garcia, JF, Gill, CA, Hiendleder, SG, Memili, E, Spurlock, D, Williams, JL, Alexander, L, Brownstein, MJ, Guan, L, Holt, RA, Jones, SJM, Marra, MA, Moore, R, Moore, SS, Roberts, A, Taniguchi, M, Waterman, RC, Chacko, J, Chandrabose, MM, Cree, A, Dao, MD, Dinh, HH, Gabisi, RA, Hines, S, Hume, J, Jhangiani, SN, Joshi, V, Kovar, CL, Lewis, LR, Liu, YS, Lopez, J, Morgan, MB, Nguyen, NB, Okwuonu, GO, Ruiz, SJ, Santibanez, J, Wright, RA, Buhay, C, Ding, Y, Dugan-Rocha, S, Herdandez, J, Holder, M, Sabo, A, Egan, A, Goodell, J, Wilczek-Boney, K, Fowler, GR, Hitchens, ME, Lozado, RJ, Moen, C, Steffen, D, Warren, JT, Zhang, J, Chiu, R, Schein, JE, Durbin, KJ, Havlak, P, Jiang, H, Liu, Y, Qin, X, Ren, Y, Shen, Y, Song, H, Bell, SN, Davis, C, Johnson, AJ, Lee, S, Nazareth, LV, Patel, BM, Pu, LL, Vattathil, S, Williams, RL, Curry, S, Hamilton, C, Sodergren, E, Wheeler, DA, Barris, W, Bennett, GL, Eggen, A, Green, RD, Harhay, GP, Hobbs, M, Jann, O, Keele, JW, Kent, MP, Lien, S, McKay, SD, McWilliam, S, Ratnakumar, A, Schnabel, RD, Smith, T, Snelling, WM, Sonstegard, TS, Stone, RT, Sugimoto, Y, Takasuga, A, Taylor, JF, Van Tassell, CP, MacNeil, MD, Abatepaulo, ARR, Abbey, CA, Ahola, V, Almeida, LG, Amadio, AF, Anatriello, E, Bahadue, SM, Biase, FH, Boldt, CR, Carroll, JA, Carvalho, WA, Cervelatti, EP, Chacko, E, Chapin, JE, Cheng, Y, Choi, J, Colley, AJ, DeCampos, TA, De Donato, M, De Miranda Santos, IKF, De Oliveira, CJF, Deobald, H, Devinoy, E, Donohue, KE, Dove, P, Eberlein, A, Fitzsimmons, CJ, Franzin, AM, Garcia, GR, Genini, S, Gladney, CJ, Grant, JR, Greaser, ML, Green, JA, Hadsell, DL, Hakimov, HA, Halgren, R, Harrow, JL, Hart, EA, Hastings, N, Hernandez, M, Hu, ZL, Iivanainen, A, Ingham, A, Iso-Touru, T, Jamis, C, Jensen, K, Kapetis, D, Kerr, T, Khalil, SS, Khatib, H, Kolbehdari, D, Kumar, CG, Kumar, D, Leach, R, Lee, JCM, Li, C, Logan, KM, Malinverni, R, Marques, E, Martin, WF, Martins, NF, Maruyama, SR, Mazza, R, McLean, KL, Medrano, JF, Moreno, BT, More, DD, Muntean, CT, Nandakumar, HP, Nogueira, MFG, Olsaker, I, Pant, SD, Panzitta, F, Pastor, RCP, Poli, MA, Poslusny, N, Rachagani, S, Ranganathan, S, Razpet, A, Riggs, PK, Rincón, G, Rodriguez-Osorio, N, Rodriguez-Zas, SL, Romero, NE, Rosenwald, A, Sando, L, Schmutz, SM, Shen, L, Sherman, L, Southey, BR, Lutzow, YS, Sweedler, JV, Tammen, I, Telugu, BPVL, Urbanski, JM, Utsunomiya, YT, Verschoor, CP, Waardenberg, AJ, Wang, Z, Ward, R, WeiKard, R, Welsh, TH, White, SN, Wilming, LG, Wunderlich, KR, Yang, J & Zhao, FQ 2009, 'The genome sequence of taurine cattle: A window to ruminant biology and evolution', Science, vol. 324, no. 5926, pp. 522-528. https://doi.org/10.1126/science.1169588
Elsik CG, Tellam RL, Worley KC, Gibbs RA, Muzny DM, Weinstock GM et al. The genome sequence of taurine cattle: A window to ruminant biology and evolution. Science. 2009 Apr 24;324(5926):522-528. https://doi.org/10.1126/science.1169588
Elsik, Christine G. ; Tellam, Ross L. ; Worley, Kim C. ; Gibbs, Richard A. ; Muzny, Donna M. ; Weinstock, George M. ; Adelson, David L. ; Eichler, Evan E. ; Elnitski, Laura ; Guigó, Roderic ; Hamernik, Debora L. ; Kappes, Steve M. ; Lewin, Harris A. ; Lynn, David J. ; Nicholas, Frank W. ; Reymond, Alexandre ; Rijnkels, Monique ; Skow, Loren C. ; Zdobnov, Evgeny M. ; Schook, Lawrence ; Womack, James ; Alioto, Tyler ; Antonarakis, Stylianos E. ; Astashyn, Alex ; Chappie, Charles E. ; Chen, Hsiu Chuan ; Chrast, Jacqueline ; Câmara, Francisco ; Ermolaeva, Olga ; Henrichsen, Charlotte N. ; Hlavina, Wratko ; Kapustin, Yuri ; Kiryutin, Boris ; Kitts, Paul ; Kokocinski, Felix ; Landrum, Melissa ; Maglott, Donna ; Pruitt, Kim ; Sapojnikov, Victor ; Searle, Stephen M. ; Solovyev, Victor ; Souvorov, Alexandre ; Ucla, Catherine ; Wyss, Carine ; Anzola, Juan M. ; Gerlach, Daniel ; Elhaik, Eran ; Graur, Dan ; Reese, Justin T. ; Edgar, Robert C. ; McEwan, John C. ; Payne, Gemma M. ; Raison, Joy M. ; Junier, Thomas ; Kriventseva, Evgenia V. ; Eyras, Eduardo ; Plass, Mireya ; Donthu, Ravikiran ; Larkin, Denis M. ; Reecy, James ; Yang, Mary Q. ; Chen, Lin ; Cheng, Ze ; Chitko-McKown, Carol G. ; Liu, George E. ; Matukumalli, Lakshmi K. ; Song, Jiuzhou ; Zhu, Bin ; Bradley, Daniel G. ; Brinkman, Fiona S L ; Lau, Lilian P L ; Whiteside, Matthew D. ; Walker, Angela ; Wheeler, Thomas T. ; Casey, Theresa ; German, J. Bruce ; Lemay, Danielle G. ; Maqbool, Nauman J. ; Molenaar, Adrian J. ; Seo, Seongwon ; Stothard, Paul ; Baldwin, Cynthia L. ; Baxter, Rebecca ; Brinkmeyer-Larigford, Candice L. ; Brown, Wendy C. ; Childers, Christopher P. ; Connelley, Timothy ; Ellis, Shirley A. ; Fritz, Krista ; Glass, Elizabeth J. ; Herzig, Carolyn T A ; Livanainen, Antti ; Lahmers, Kevin K. ; Bennett, Anna K. ; Dickens, C. Michael ; Gilbert, James G R ; Hagen, Darren E. ; Salih, Hanni ; Aerts, Jan ; Caetano, Alexandre R. ; Dalrymple, Brian ; Garcia, Jose Fernando ; Gill, Clare A. ; Hiendleder, Stefan G. ; Memili, Erdogan ; Spurlock, Diane ; Williams, John L. ; Alexander, Lee ; Brownstein, Michael J. ; Guan, Leluo ; Holt, Robert A. ; Jones, Steven J M ; Marra, Marco A. ; Moore, Richard ; Moore, Stephen S. ; Roberts, Andy ; Taniguchi, Masaaki ; Waterman, Richard C. ; Chacko, Joseph ; Chandrabose, Mimi M. ; Cree, Andy ; Dao, Marvin Diep ; Dinh, Huyen H. ; Gabisi, Ramatu Ayiesha ; Hines, Sandra ; Hume, Jennifer ; Jhangiani, Shalini N. ; Joshi, Vandita ; Kovar, Christie L. ; Lewis, Lora R. ; Liu, Yin Shin ; Lopez, John ; Morgan, Margaret B. ; Nguyen, Ngoc Bich ; Okwuonu, Geoffrey O. ; Ruiz, San Juana ; Santibanez, Jireh ; Wright, Rita A. ; Buhay, Christian ; Ding, Yan ; Dugan-Rocha, Shannon ; Herdandez, Judith ; Holder, Michael ; Sabo, Aniko ; Egan, Amy ; Goodell, Jason ; Wilczek-Boney, Katarzyna ; Fowler, Gerald R. ; Hitchens, Matthew Edward ; Lozado, Ryan J. ; Moen, Charles ; Steffen, David ; Warren, James T. ; Zhang, Jingkun ; Chiu, Readman ; Schein, Jacqueline E. ; Durbin, K. James ; Havlak, Paul ; Jiang, Huaiyang ; Liu, Yue ; Qin, Xiang ; Ren, Yanru ; Shen, Yufeng ; Song, Henry ; Bell, Stephanie Nicole ; Davis, Clay ; Johnson, Angela Jolivet ; Lee, Sandra ; Nazareth, Lynne V. ; Patel, Bella Mayurkumar ; Pu, Ling Ling ; Vattathil, Selina ; Williams, Rex Lee ; Curry, Stacey ; Hamilton, Cerissa ; Sodergren, Erica ; Wheeler, David A. ; Barris, Wes ; Bennett, Gary L. ; Eggen, Andre ; Green, Ronnie D. ; Harhay, Gregory P. ; Hobbs, Matthew ; Jann, Oliver ; Keele, John W. ; Kent, Matthew P. ; Lien, Sigbjam ; McKay, Stephanie D. ; McWilliam, Sean ; Ratnakumar, Abhirami ; Schnabel, Robert D. ; Smith, Timothy ; Snelling, Warren M. ; Sonstegard, Tad S. ; Stone, Roger T. ; Sugimoto, Yoshikazu ; Takasuga, Akiko ; Taylor, Jeremy F. ; Van Tassell, Curtis P. ; MacNeil, Michael D. ; Abatepaulo, Antonio R R ; Abbey, Colette A. ; Ahola, Virpi ; Almeida, Lassudara G. ; Amadio, Ariel F. ; Anatriello, Elen ; Bahadue, Suria M. ; Biase, Fernando H. ; Boldt, Clayton R. ; Carroll, Jeffery A. ; Carvalho, Wanessa A. ; Cervelatti, Eliane P. ; Chacko, Elsa ; Chapin, Jennifer E. ; Cheng, Ye ; Choi, Jungwoo ; Colley, Adam J. ; DeCampos, Tatiana A. ; De Donato, Marcos ; De Miranda Santos, Isabel K F ; De Oliveira, Carlo J F ; Deobald, Heather ; Devinoy, Eve ; Donohue, Kaitlin E. ; Dove, Peter ; Eberlein, Annett ; Fitzsimmons, Carolyn J. ; Franzin, Alessandra M. ; Garcia, Gustavo R. ; Genini, Sem ; Gladney, Cody J. ; Grant, Jason R. ; Greaser, Marion L. ; Green, Jonathan A. ; Hadsell, Darryl L. ; Hakimov, Hatam A. ; Halgren, Rob ; Harrow, Jennifer L. ; Hart, Elizabeth A. ; Hastings, Nicola ; Hernandez, Marta ; Hu, Zhi Liang ; Iivanainen, Antti ; Ingham, Aaron ; Iso-Touru, Terhi ; Jamis, Catherine ; Jensen, Kirsty ; Kapetis, Dimos ; Kerr, Tovah ; Khalil, Sari S. ; Khatib, Hasan ; Kolbehdari, Davood ; Kumar, Cham G. ; Kumar, Dinesh ; Leach, Richard ; Lee, Justin C M ; Li, Changxi ; Logan, Krystin M. ; Malinverni, Roberto ; Marques, Elisa ; Martin, William F. ; Martins, Natalia F. ; Maruyama, Sandra R. ; Mazza, Raffaele ; McLean, Kim L. ; Medrano, Juan F. ; Moreno, Barbara T. ; More, Daniela D. ; Muntean, Carl T. ; Nandakumar, Hari P. ; Nogueira, Marcelo F G ; Olsaker, Ingrid ; Pant, Sameer D. ; Panzitta, Francesca ; Pastor, Rosemeire C P ; Poli, Mario A. ; Poslusny, Nathan ; Rachagani, Satyanarayana ; Ranganathan, Shoba ; Razpet, Andrej ; Riggs, Penny K. ; Rincón, Gonzalo ; Rodriguez-Osorio, Nelida ; Rodriguez-Zas, Sandra L. ; Romero, Natasha E. ; Rosenwald, Anne ; Sando, Lillian ; Schmutz, Sheila M. ; Shen, Libing ; Sherman, Laura ; Southey, Bruce R. ; Lutzow, Ylva Strandberg ; Sweedler, Jonathan V. ; Tammen, Imke ; Telugu, Bhanu Prakash V L ; Urbanski, Jennifer M. ; Utsunomiya, Yuri T. ; Verschoor, Chris P. ; Waardenberg, Ashley J. ; Wang, Zhiquan ; Ward, Robert ; WeiKard, Rosemarie ; Welsh, Thomas H. ; White, Stephen N. ; Wilming, Laurens G. ; Wunderlich, Kris R. ; Yang, Jianqi ; Zhao, Feng Qi. / The genome sequence of taurine cattle : A window to ruminant biology and evolution. In: Science. 2009 ; Vol. 324, No. 5926. pp. 522-528.
@article{4c7031e6820e4f92895f531ac4d60386,
title = "The genome sequence of taurine cattle: A window to ruminant biology and evolution",
abstract = "To understand the biology and evolution of ruminants, the cattle genome was sequenced to about sevenfold coverage. The cattle genome contains a minimum of 22,000 genes, with a core set of 14,345 orthologs shared among seven mammalian species of which 1217 are absent or undetected in noneutherian (marsupial or monotreme) genomes. Cattle-specific evolutionary breakpoint regions in chromosomes have a higher density of segmental duplications, enrichment of repetitive elements, and species-specific variations in genes associated with lactation and immune responsiveness. Genes involved in metabolism are generally highly conserved, although five metabolic genes are deleted or extensively diverged from their human orthologs. The cattle genome sequence thu5 provides a resource for understanding mammalian evolution and accelerating livestock genetic improvement for milk and meat production.",
author = "Elsik, {Christine G.} and Tellam, {Ross L.} and Worley, {Kim C.} and Gibbs, {Richard A.} and Muzny, {Donna M.} and Weinstock, {George M.} and Adelson, {David L.} and Eichler, {Evan E.} and Laura Elnitski and Roderic Guig{\'o} and Hamernik, {Debora L.} and Kappes, {Steve M.} and Lewin, {Harris A.} and Lynn, {David J.} and Nicholas, {Frank W.} and Alexandre Reymond and Monique Rijnkels and Skow, {Loren C.} and Zdobnov, {Evgeny M.} and Lawrence Schook and James Womack and Tyler Alioto and Antonarakis, {Stylianos E.} and Alex Astashyn and Chappie, {Charles E.} and Chen, {Hsiu Chuan} and Jacqueline Chrast and Francisco C{\^a}mara and Olga Ermolaeva and Henrichsen, {Charlotte N.} and Wratko Hlavina and Yuri Kapustin and Boris Kiryutin and Paul Kitts and Felix Kokocinski and Melissa Landrum and Donna Maglott and Kim Pruitt and Victor Sapojnikov and Searle, {Stephen M.} and Victor Solovyev and Alexandre Souvorov and Catherine Ucla and Carine Wyss and Anzola, {Juan M.} and Daniel Gerlach and Eran Elhaik and Dan Graur and Reese, {Justin T.} and Edgar, {Robert C.} and McEwan, {John C.} and Payne, {Gemma M.} and Raison, {Joy M.} and Thomas Junier and Kriventseva, {Evgenia V.} and Eduardo Eyras and Mireya Plass and Ravikiran Donthu and Larkin, {Denis M.} and James Reecy and Yang, {Mary Q.} and Lin Chen and Ze Cheng and Chitko-McKown, {Carol G.} and Liu, {George E.} and Matukumalli, {Lakshmi K.} and Jiuzhou Song and Bin Zhu and Bradley, {Daniel G.} and Brinkman, {Fiona S L} and Lau, {Lilian P L} and Whiteside, {Matthew D.} and Angela Walker and Wheeler, {Thomas T.} and Theresa Casey and German, {J. Bruce} and Lemay, {Danielle G.} and Maqbool, {Nauman J.} and Molenaar, {Adrian J.} and Seongwon Seo and Paul Stothard and Baldwin, {Cynthia L.} and Rebecca Baxter and Brinkmeyer-Larigford, {Candice L.} and Brown, {Wendy C.} and Childers, {Christopher P.} and Timothy Connelley and Ellis, {Shirley A.} and Krista Fritz and Glass, {Elizabeth J.} and Herzig, {Carolyn T A} and Antti Livanainen and Lahmers, {Kevin K.} and Bennett, {Anna K.} and Dickens, {C. Michael} and Gilbert, {James G R} and Hagen, {Darren E.} and Hanni Salih and Jan Aerts and Caetano, {Alexandre R.} and Brian Dalrymple and Garcia, {Jose Fernando} and Gill, {Clare A.} and Hiendleder, {Stefan G.} and Erdogan Memili and Diane Spurlock and Williams, {John L.} and Lee Alexander and Brownstein, {Michael J.} and Leluo Guan and Holt, {Robert A.} and Jones, {Steven J M} and Marra, {Marco A.} and Richard Moore and Moore, {Stephen S.} and Andy Roberts and Masaaki Taniguchi and Waterman, {Richard C.} and Joseph Chacko and Chandrabose, {Mimi M.} and Andy Cree and Dao, {Marvin Diep} and Dinh, {Huyen H.} and Gabisi, {Ramatu Ayiesha} and Sandra Hines and Jennifer Hume and Jhangiani, {Shalini N.} and Vandita Joshi and Kovar, {Christie L.} and Lewis, {Lora R.} and Liu, {Yin Shin} and John Lopez and Morgan, {Margaret B.} and Nguyen, {Ngoc Bich} and Okwuonu, {Geoffrey O.} and Ruiz, {San Juana} and Jireh Santibanez and Wright, {Rita A.} and Christian Buhay and Yan Ding and Shannon Dugan-Rocha and Judith Herdandez and Michael Holder and Aniko Sabo and Amy Egan and Jason Goodell and Katarzyna Wilczek-Boney and Fowler, {Gerald R.} and Hitchens, {Matthew Edward} and Lozado, {Ryan J.} and Charles Moen and David Steffen and Warren, {James T.} and Jingkun Zhang and Readman Chiu and Schein, {Jacqueline E.} and Durbin, {K. James} and Paul Havlak and Huaiyang Jiang and Yue Liu and Xiang Qin and Yanru Ren and Yufeng Shen and Henry Song and Bell, {Stephanie Nicole} and Clay Davis and Johnson, {Angela Jolivet} and Sandra Lee and Nazareth, {Lynne V.} and Patel, {Bella Mayurkumar} and Pu, {Ling Ling} and Selina Vattathil and Williams, {Rex Lee} and Stacey Curry and Cerissa Hamilton and Erica Sodergren and Wheeler, {David A.} and Wes Barris and Bennett, {Gary L.} and Andre Eggen and Green, {Ronnie D.} and Harhay, {Gregory P.} and Matthew Hobbs and Oliver Jann and Keele, {John W.} and Kent, {Matthew P.} and Sigbjam Lien and McKay, {Stephanie D.} and Sean McWilliam and Abhirami Ratnakumar and Schnabel, {Robert D.} and Timothy Smith and Snelling, {Warren M.} and Sonstegard, {Tad S.} and Stone, {Roger T.} and Yoshikazu Sugimoto and Akiko Takasuga and Taylor, {Jeremy F.} and {Van Tassell}, {Curtis P.} and MacNeil, {Michael D.} and Abatepaulo, {Antonio R R} and Abbey, {Colette A.} and Virpi Ahola and Almeida, {Lassudara G.} and Amadio, {Ariel F.} and Elen Anatriello and Bahadue, {Suria M.} and Biase, {Fernando H.} and Boldt, {Clayton R.} and Carroll, {Jeffery A.} and Carvalho, {Wanessa A.} and Cervelatti, {Eliane P.} and Elsa Chacko and Chapin, {Jennifer E.} and Ye Cheng and Jungwoo Choi and Colley, {Adam J.} and DeCampos, {Tatiana A.} and {De Donato}, Marcos and {De Miranda Santos}, {Isabel K F} and {De Oliveira}, {Carlo J F} and Heather Deobald and Eve Devinoy and Donohue, {Kaitlin E.} and Peter Dove and Annett Eberlein and Fitzsimmons, {Carolyn J.} and Franzin, {Alessandra M.} and Garcia, {Gustavo R.} and Sem Genini and Gladney, {Cody J.} and Grant, {Jason R.} and Greaser, {Marion L.} and Green, {Jonathan A.} and Hadsell, {Darryl L.} and Hakimov, {Hatam A.} and Rob Halgren and Harrow, {Jennifer L.} and Hart, {Elizabeth A.} and Nicola Hastings and Marta Hernandez and Hu, {Zhi Liang} and Antti Iivanainen and Aaron Ingham and Terhi Iso-Touru and Catherine Jamis and Kirsty Jensen and Dimos Kapetis and Tovah Kerr and Khalil, {Sari S.} and Hasan Khatib and Davood Kolbehdari and Kumar, {Cham G.} and Dinesh Kumar and Richard Leach and Lee, {Justin C M} and Changxi Li and Logan, {Krystin M.} and Roberto Malinverni and Elisa Marques and Martin, {William F.} and Martins, {Natalia F.} and Maruyama, {Sandra R.} and Raffaele Mazza and McLean, {Kim L.} and Medrano, {Juan F.} and Moreno, {Barbara T.} and More, {Daniela D.} and Muntean, {Carl T.} and Nandakumar, {Hari P.} and Nogueira, {Marcelo F G} and Ingrid Olsaker and Pant, {Sameer D.} and Francesca Panzitta and Pastor, {Rosemeire C P} and Poli, {Mario A.} and Nathan Poslusny and Satyanarayana Rachagani and Shoba Ranganathan and Andrej Razpet and Riggs, {Penny K.} and Gonzalo Rinc{\'o}n and Nelida Rodriguez-Osorio and Rodriguez-Zas, {Sandra L.} and Romero, {Natasha E.} and Anne Rosenwald and Lillian Sando and Schmutz, {Sheila M.} and Libing Shen and Laura Sherman and Southey, {Bruce R.} and Lutzow, {Ylva Strandberg} and Sweedler, {Jonathan V.} and Imke Tammen and Telugu, {Bhanu Prakash V L} and Urbanski, {Jennifer M.} and Utsunomiya, {Yuri T.} and Verschoor, {Chris P.} and Waardenberg, {Ashley J.} and Zhiquan Wang and Robert Ward and Rosemarie WeiKard and Welsh, {Thomas H.} and White, {Stephen N.} and Wilming, {Laurens G.} and Wunderlich, {Kris R.} and Jianqi Yang and Zhao, {Feng Qi}",
year = "2009",
month = "4",
day = "24",
doi = "10.1126/science.1169588",
language = "English (US)",
volume = "324",
pages = "522--528",
journal = "Science",
issn = "0036-8075",
publisher = "American Association for the Advancement of Science",
number = "5926",

}

TY - JOUR

T1 - The genome sequence of taurine cattle

T2 - A window to ruminant biology and evolution

AU - Elsik, Christine G.

AU - Tellam, Ross L.

AU - Worley, Kim C.

AU - Gibbs, Richard A.

AU - Muzny, Donna M.

AU - Weinstock, George M.

AU - Adelson, David L.

AU - Eichler, Evan E.

AU - Elnitski, Laura

AU - Guigó, Roderic

AU - Hamernik, Debora L.

AU - Kappes, Steve M.

AU - Lewin, Harris A.

AU - Lynn, David J.

AU - Nicholas, Frank W.

AU - Reymond, Alexandre

AU - Rijnkels, Monique

AU - Skow, Loren C.

AU - Zdobnov, Evgeny M.

AU - Schook, Lawrence

AU - Womack, James

AU - Alioto, Tyler

AU - Antonarakis, Stylianos E.

AU - Astashyn, Alex

AU - Chappie, Charles E.

AU - Chen, Hsiu Chuan

AU - Chrast, Jacqueline

AU - Câmara, Francisco

AU - Ermolaeva, Olga

AU - Henrichsen, Charlotte N.

AU - Hlavina, Wratko

AU - Kapustin, Yuri

AU - Kiryutin, Boris

AU - Kitts, Paul

AU - Kokocinski, Felix

AU - Landrum, Melissa

AU - Maglott, Donna

AU - Pruitt, Kim

AU - Sapojnikov, Victor

AU - Searle, Stephen M.

AU - Solovyev, Victor

AU - Souvorov, Alexandre

AU - Ucla, Catherine

AU - Wyss, Carine

AU - Anzola, Juan M.

AU - Gerlach, Daniel

AU - Elhaik, Eran

AU - Graur, Dan

AU - Reese, Justin T.

AU - Edgar, Robert C.

AU - McEwan, John C.

AU - Payne, Gemma M.

AU - Raison, Joy M.

AU - Junier, Thomas

AU - Kriventseva, Evgenia V.

AU - Eyras, Eduardo

AU - Plass, Mireya

AU - Donthu, Ravikiran

AU - Larkin, Denis M.

AU - Reecy, James

AU - Yang, Mary Q.

AU - Chen, Lin

AU - Cheng, Ze

AU - Chitko-McKown, Carol G.

AU - Liu, George E.

AU - Matukumalli, Lakshmi K.

AU - Song, Jiuzhou

AU - Zhu, Bin

AU - Bradley, Daniel G.

AU - Brinkman, Fiona S L

AU - Lau, Lilian P L

AU - Whiteside, Matthew D.

AU - Walker, Angela

AU - Wheeler, Thomas T.

AU - Casey, Theresa

AU - German, J. Bruce

AU - Lemay, Danielle G.

AU - Maqbool, Nauman J.

AU - Molenaar, Adrian J.

AU - Seo, Seongwon

AU - Stothard, Paul

AU - Baldwin, Cynthia L.

AU - Baxter, Rebecca

AU - Brinkmeyer-Larigford, Candice L.

AU - Brown, Wendy C.

AU - Childers, Christopher P.

AU - Connelley, Timothy

AU - Ellis, Shirley A.

AU - Fritz, Krista

AU - Glass, Elizabeth J.

AU - Herzig, Carolyn T A

AU - Livanainen, Antti

AU - Lahmers, Kevin K.

AU - Bennett, Anna K.

AU - Dickens, C. Michael

AU - Gilbert, James G R

AU - Hagen, Darren E.

AU - Salih, Hanni

AU - Aerts, Jan

AU - Caetano, Alexandre R.

AU - Dalrymple, Brian

AU - Garcia, Jose Fernando

AU - Gill, Clare A.

AU - Hiendleder, Stefan G.

AU - Memili, Erdogan

AU - Spurlock, Diane

AU - Williams, John L.

AU - Alexander, Lee

AU - Brownstein, Michael J.

AU - Guan, Leluo

AU - Holt, Robert A.

AU - Jones, Steven J M

AU - Marra, Marco A.

AU - Moore, Richard

AU - Moore, Stephen S.

AU - Roberts, Andy

AU - Taniguchi, Masaaki

AU - Waterman, Richard C.

AU - Chacko, Joseph

AU - Chandrabose, Mimi M.

AU - Cree, Andy

AU - Dao, Marvin Diep

AU - Dinh, Huyen H.

AU - Gabisi, Ramatu Ayiesha

AU - Hines, Sandra

AU - Hume, Jennifer

AU - Jhangiani, Shalini N.

AU - Joshi, Vandita

AU - Kovar, Christie L.

AU - Lewis, Lora R.

AU - Liu, Yin Shin

AU - Lopez, John

AU - Morgan, Margaret B.

AU - Nguyen, Ngoc Bich

AU - Okwuonu, Geoffrey O.

AU - Ruiz, San Juana

AU - Santibanez, Jireh

AU - Wright, Rita A.

AU - Buhay, Christian

AU - Ding, Yan

AU - Dugan-Rocha, Shannon

AU - Herdandez, Judith

AU - Holder, Michael

AU - Sabo, Aniko

AU - Egan, Amy

AU - Goodell, Jason

AU - Wilczek-Boney, Katarzyna

AU - Fowler, Gerald R.

AU - Hitchens, Matthew Edward

AU - Lozado, Ryan J.

AU - Moen, Charles

AU - Steffen, David

AU - Warren, James T.

AU - Zhang, Jingkun

AU - Chiu, Readman

AU - Schein, Jacqueline E.

AU - Durbin, K. James

AU - Havlak, Paul

AU - Jiang, Huaiyang

AU - Liu, Yue

AU - Qin, Xiang

AU - Ren, Yanru

AU - Shen, Yufeng

AU - Song, Henry

AU - Bell, Stephanie Nicole

AU - Davis, Clay

AU - Johnson, Angela Jolivet

AU - Lee, Sandra

AU - Nazareth, Lynne V.

AU - Patel, Bella Mayurkumar

AU - Pu, Ling Ling

AU - Vattathil, Selina

AU - Williams, Rex Lee

AU - Curry, Stacey

AU - Hamilton, Cerissa

AU - Sodergren, Erica

AU - Wheeler, David A.

AU - Barris, Wes

AU - Bennett, Gary L.

AU - Eggen, Andre

AU - Green, Ronnie D.

AU - Harhay, Gregory P.

AU - Hobbs, Matthew

AU - Jann, Oliver

AU - Keele, John W.

AU - Kent, Matthew P.

AU - Lien, Sigbjam

AU - McKay, Stephanie D.

AU - McWilliam, Sean

AU - Ratnakumar, Abhirami

AU - Schnabel, Robert D.

AU - Smith, Timothy

AU - Snelling, Warren M.

AU - Sonstegard, Tad S.

AU - Stone, Roger T.

AU - Sugimoto, Yoshikazu

AU - Takasuga, Akiko

AU - Taylor, Jeremy F.

AU - Van Tassell, Curtis P.

AU - MacNeil, Michael D.

AU - Abatepaulo, Antonio R R

AU - Abbey, Colette A.

AU - Ahola, Virpi

AU - Almeida, Lassudara G.

AU - Amadio, Ariel F.

AU - Anatriello, Elen

AU - Bahadue, Suria M.

AU - Biase, Fernando H.

AU - Boldt, Clayton R.

AU - Carroll, Jeffery A.

AU - Carvalho, Wanessa A.

AU - Cervelatti, Eliane P.

AU - Chacko, Elsa

AU - Chapin, Jennifer E.

AU - Cheng, Ye

AU - Choi, Jungwoo

AU - Colley, Adam J.

AU - DeCampos, Tatiana A.

AU - De Donato, Marcos

AU - De Miranda Santos, Isabel K F

AU - De Oliveira, Carlo J F

AU - Deobald, Heather

AU - Devinoy, Eve

AU - Donohue, Kaitlin E.

AU - Dove, Peter

AU - Eberlein, Annett

AU - Fitzsimmons, Carolyn J.

AU - Franzin, Alessandra M.

AU - Garcia, Gustavo R.

AU - Genini, Sem

AU - Gladney, Cody J.

AU - Grant, Jason R.

AU - Greaser, Marion L.

AU - Green, Jonathan A.

AU - Hadsell, Darryl L.

AU - Hakimov, Hatam A.

AU - Halgren, Rob

AU - Harrow, Jennifer L.

AU - Hart, Elizabeth A.

AU - Hastings, Nicola

AU - Hernandez, Marta

AU - Hu, Zhi Liang

AU - Iivanainen, Antti

AU - Ingham, Aaron

AU - Iso-Touru, Terhi

AU - Jamis, Catherine

AU - Jensen, Kirsty

AU - Kapetis, Dimos

AU - Kerr, Tovah

AU - Khalil, Sari S.

AU - Khatib, Hasan

AU - Kolbehdari, Davood

AU - Kumar, Cham G.

AU - Kumar, Dinesh

AU - Leach, Richard

AU - Lee, Justin C M

AU - Li, Changxi

AU - Logan, Krystin M.

AU - Malinverni, Roberto

AU - Marques, Elisa

AU - Martin, William F.

AU - Martins, Natalia F.

AU - Maruyama, Sandra R.

AU - Mazza, Raffaele

AU - McLean, Kim L.

AU - Medrano, Juan F.

AU - Moreno, Barbara T.

AU - More, Daniela D.

AU - Muntean, Carl T.

AU - Nandakumar, Hari P.

AU - Nogueira, Marcelo F G

AU - Olsaker, Ingrid

AU - Pant, Sameer D.

AU - Panzitta, Francesca

AU - Pastor, Rosemeire C P

AU - Poli, Mario A.

AU - Poslusny, Nathan

AU - Rachagani, Satyanarayana

AU - Ranganathan, Shoba

AU - Razpet, Andrej

AU - Riggs, Penny K.

AU - Rincón, Gonzalo

AU - Rodriguez-Osorio, Nelida

AU - Rodriguez-Zas, Sandra L.

AU - Romero, Natasha E.

AU - Rosenwald, Anne

AU - Sando, Lillian

AU - Schmutz, Sheila M.

AU - Shen, Libing

AU - Sherman, Laura

AU - Southey, Bruce R.

AU - Lutzow, Ylva Strandberg

AU - Sweedler, Jonathan V.

AU - Tammen, Imke

AU - Telugu, Bhanu Prakash V L

AU - Urbanski, Jennifer M.

AU - Utsunomiya, Yuri T.

AU - Verschoor, Chris P.

AU - Waardenberg, Ashley J.

AU - Wang, Zhiquan

AU - Ward, Robert

AU - WeiKard, Rosemarie

AU - Welsh, Thomas H.

AU - White, Stephen N.

AU - Wilming, Laurens G.

AU - Wunderlich, Kris R.

AU - Yang, Jianqi

AU - Zhao, Feng Qi

PY - 2009/4/24

Y1 - 2009/4/24

N2 - To understand the biology and evolution of ruminants, the cattle genome was sequenced to about sevenfold coverage. The cattle genome contains a minimum of 22,000 genes, with a core set of 14,345 orthologs shared among seven mammalian species of which 1217 are absent or undetected in noneutherian (marsupial or monotreme) genomes. Cattle-specific evolutionary breakpoint regions in chromosomes have a higher density of segmental duplications, enrichment of repetitive elements, and species-specific variations in genes associated with lactation and immune responsiveness. Genes involved in metabolism are generally highly conserved, although five metabolic genes are deleted or extensively diverged from their human orthologs. The cattle genome sequence thu5 provides a resource for understanding mammalian evolution and accelerating livestock genetic improvement for milk and meat production.

AB - To understand the biology and evolution of ruminants, the cattle genome was sequenced to about sevenfold coverage. The cattle genome contains a minimum of 22,000 genes, with a core set of 14,345 orthologs shared among seven mammalian species of which 1217 are absent or undetected in noneutherian (marsupial or monotreme) genomes. Cattle-specific evolutionary breakpoint regions in chromosomes have a higher density of segmental duplications, enrichment of repetitive elements, and species-specific variations in genes associated with lactation and immune responsiveness. Genes involved in metabolism are generally highly conserved, although five metabolic genes are deleted or extensively diverged from their human orthologs. The cattle genome sequence thu5 provides a resource for understanding mammalian evolution and accelerating livestock genetic improvement for milk and meat production.

UR - http://www.scopus.com/inward/record.url?scp=77951621301&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77951621301&partnerID=8YFLogxK

U2 - 10.1126/science.1169588

DO - 10.1126/science.1169588

M3 - Article

VL - 324

SP - 522

EP - 528

JO - Science

JF - Science

SN - 0036-8075

IS - 5926

ER -