The genetic epidemiology of spontaneous endometriosis in the rhesus monkey

Krina Zondervan, L. Cardon, Ronald Desrosiers, Dallas Hyde, Joseph Kemnitz, Keith Mansfield, Jeffrey A Roberts, Joan Scheffler, Daniel E. Weeks, Stephen Kennedy

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

The etiology of endometriosis is uncertain, but there is increasing evidence that it is inherited as a complex genetic trait like diabetes or asthma. In such complex traits, multiple gene loci conferring susceptibility to the disease interact with each other and the environment to produce the phenotype. The study of such interactions in humans can be problematic. Thus, the availability of an animal model, which shares many aspects of anatomy and physiology with humans, is potentially a valuable tool for investigating the genetic epidemiology of the disease. Since endometriosis develops spontaneously in the rhesus monkey (Macaca mulatta) and the tissue is morphologically identical to its human counterpart, this population provides a unique opportunity to conduct such studies in this condition.

Original languageEnglish (US)
Pages (from-to)233-238
Number of pages6
JournalAnnals of the New York Academy of Sciences
Volume955
StatePublished - 2002

Fingerprint

Molecular Epidemiology
Endometriosis
Macaca mulatta
Physiology
Medical problems
Inborn Genetic Diseases
Animals
Genes
Disease Susceptibility
Availability
Tissue
Anatomy
Asthma
Animal Models
Phenotype
Population
Monkey
Epidemiology

Keywords

  • Endometriosis
  • Epidemiology
  • Genetics
  • Rhesus monkey

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Zondervan, K., Cardon, L., Desrosiers, R., Hyde, D., Kemnitz, J., Mansfield, K., ... Kennedy, S. (2002). The genetic epidemiology of spontaneous endometriosis in the rhesus monkey. Annals of the New York Academy of Sciences, 955, 233-238.

The genetic epidemiology of spontaneous endometriosis in the rhesus monkey. / Zondervan, Krina; Cardon, L.; Desrosiers, Ronald; Hyde, Dallas; Kemnitz, Joseph; Mansfield, Keith; Roberts, Jeffrey A; Scheffler, Joan; Weeks, Daniel E.; Kennedy, Stephen.

In: Annals of the New York Academy of Sciences, Vol. 955, 2002, p. 233-238.

Research output: Contribution to journalArticle

Zondervan, K, Cardon, L, Desrosiers, R, Hyde, D, Kemnitz, J, Mansfield, K, Roberts, JA, Scheffler, J, Weeks, DE & Kennedy, S 2002, 'The genetic epidemiology of spontaneous endometriosis in the rhesus monkey', Annals of the New York Academy of Sciences, vol. 955, pp. 233-238.
Zondervan K, Cardon L, Desrosiers R, Hyde D, Kemnitz J, Mansfield K et al. The genetic epidemiology of spontaneous endometriosis in the rhesus monkey. Annals of the New York Academy of Sciences. 2002;955:233-238.
Zondervan, Krina ; Cardon, L. ; Desrosiers, Ronald ; Hyde, Dallas ; Kemnitz, Joseph ; Mansfield, Keith ; Roberts, Jeffrey A ; Scheffler, Joan ; Weeks, Daniel E. ; Kennedy, Stephen. / The genetic epidemiology of spontaneous endometriosis in the rhesus monkey. In: Annals of the New York Academy of Sciences. 2002 ; Vol. 955. pp. 233-238.
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