The gene for the homeodomain-containing protein Cart-1 is expressed in cells that have a chondrogenic potential during embryonic development

Guang Quan Zhao, Heidi Eberspaecher, Michael F Seldin, Benoit de Crombrugghe

Research output: Contribution to journalArticle

75 Citations (Scopus)

Abstract

We have examined the expression of the gene for Cart-1, a new homeodomain-containing protein, during rat embryonic development. In early embryos, Cart-1 RNA was detected at high levels in head mesenchyme, lateral mesoderm, sclerotomes and limb bud mesenchyme. These tissues contain prechondrocytic mesenchymal cells responsible for the formation of the cartilaginous skeleton. In addition, Cart-1 RNA was also found in lung buds, tendons and mesonephros. Cells in these tissues have the potential of undergoing chondrogenesis either in explants for mesonephros and tendons, or in vivo for tendons and the precursors of bronchi cartilages. No hybridization was observed in brain, spinal cord, heart, spleen, gastrointestinal tract, liver and muscle. Our results support the hypothesis that Cart-1 may play a role in the pathway of chondrogenesis. The gene for Cart-1 was mapped to a segment of mouse chromosome 10 between the genes for phenylalanine hydroxylase and interferon gamma.

Original languageEnglish (US)
Pages (from-to)245-254
Number of pages10
JournalMechanisms of Development
Volume48
Issue number3
DOIs
StatePublished - 1994
Externally publishedYes

Fingerprint

Homeodomain Proteins
Mesoderm
Mesonephros
Tendons
Embryonic Development
Chondrogenesis
RNA
Phenylalanine Hydroxylase
Genes
Limb Buds
Chromosomes, Human, Pair 10
Bronchi
Skeleton
Interferon-gamma
Cartilage
Gastrointestinal Tract
Spinal Cord
Spleen
Embryonic Structures
Head

Keywords

  • Cartilage
  • Chondrogenesis
  • Embryonic development
  • Homeobox

ASJC Scopus subject areas

  • Developmental Biology
  • Developmental Neuroscience

Cite this

The gene for the homeodomain-containing protein Cart-1 is expressed in cells that have a chondrogenic potential during embryonic development. / Zhao, Guang Quan; Eberspaecher, Heidi; Seldin, Michael F; de Crombrugghe, Benoit.

In: Mechanisms of Development, Vol. 48, No. 3, 1994, p. 245-254.

Research output: Contribution to journalArticle

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