The Gastrointestinal Tract and Control of Food Intake

Guillaume de Lartigue, Helen E Raybould

Research output: Chapter in Book/Report/Conference proceedingChapter


Control of food intake and body weight involves multiple pathways and body systems. Recent evidence, in part from the effectiveness of bariatric surgical procedures in treatment of obesity and metabolic disease, but also from the availability of transgenic mice, suggests that the gut can play a predominant role in the long-term regulation of food intake, appetitive behavior, and overall energy balance. Here we review the mechanisms in the gut and the pathways from the gut to the brain that can influence these processes. Information is also included on how these mechanisms and gut-brain pathways may change in obesity and metabolic disease, and the role the gut microbiota might play in mediating these changes.

Original languageEnglish (US)
Title of host publicationPhysiology of the Gastrointestinal Tract
Subtitle of host publicationSixth Edition
PublisherElsevier Inc.
Number of pages15
ISBN (Electronic)9780128124260
ISBN (Print)9780128099544
StatePublished - Mar 28 2018


  • Anorexigenic
  • Bariatric surgery
  • Brainstem
  • Cholecystokinin
  • Enteroendocrine cells
  • Ghrelin
  • Glucagon-like peptide-1
  • Gut microbiota
  • Hypothalamus
  • Leptin
  • Limbic system
  • Nutrient sensing
  • Orexigenic
  • Vagal afferents

ASJC Scopus subject areas

  • Medicine(all)


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