Abstract
Long thought to be a sterile habitat, the stomach contains a diverse and unique community of bacteria. One particular inhabitant, Helicobacter pylori, colonizes half of the world’s human population and establishes a decadeslong infection that can be asymptomatic, pathogenic, or even beneficial for the host. Many host and bacterial factors are known to influence an individual’s risk of gastric disease, but another potentially important determinant has recently come to light: the host microbiota. Although it is unclear to what extent H. pylori infection perturbs the established gastric microbial community, and H. pylori colonization seems generally resistant to disturbances in the host microbiota, it can modulate H. pylori pathogenicity. Interactions between H. pylori and bacteria at nongastric sites are likely indirect-via programming of the pro-inflammatory vs. regulatory T lymphocytes-which may have a significant impact on human health.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 345-350 |
| Number of pages | 6 |
| Journal | Gut Microbes |
| Volume | 5 |
| Issue number | 3 |
| DOIs | |
| State | Published - 2014 |
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Keywords
- 16S rDNA
- Disease
- Helicobacter pylori
- Human
- Microbial community
- Microbiota
- Mouse
- Rhesus monkey
- Stomach
ASJC Scopus subject areas
- Microbiology
- Gastroenterology
- Microbiology (medical)
- Infectious Diseases
Cite this
The gastric microbial community, Helicobacter pylori colonization, and disease. / Martin, Miriam E.; Solnick, Jay V.
In: Gut Microbes, Vol. 5, No. 3, 2014, p. 345-350.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The gastric microbial community, Helicobacter pylori colonization, and disease
AU - Martin, Miriam E.
AU - Solnick, Jay V
PY - 2014
Y1 - 2014
N2 - Long thought to be a sterile habitat, the stomach contains a diverse and unique community of bacteria. One particular inhabitant, Helicobacter pylori, colonizes half of the world’s human population and establishes a decadeslong infection that can be asymptomatic, pathogenic, or even beneficial for the host. Many host and bacterial factors are known to influence an individual’s risk of gastric disease, but another potentially important determinant has recently come to light: the host microbiota. Although it is unclear to what extent H. pylori infection perturbs the established gastric microbial community, and H. pylori colonization seems generally resistant to disturbances in the host microbiota, it can modulate H. pylori pathogenicity. Interactions between H. pylori and bacteria at nongastric sites are likely indirect-via programming of the pro-inflammatory vs. regulatory T lymphocytes-which may have a significant impact on human health.
AB - Long thought to be a sterile habitat, the stomach contains a diverse and unique community of bacteria. One particular inhabitant, Helicobacter pylori, colonizes half of the world’s human population and establishes a decadeslong infection that can be asymptomatic, pathogenic, or even beneficial for the host. Many host and bacterial factors are known to influence an individual’s risk of gastric disease, but another potentially important determinant has recently come to light: the host microbiota. Although it is unclear to what extent H. pylori infection perturbs the established gastric microbial community, and H. pylori colonization seems generally resistant to disturbances in the host microbiota, it can modulate H. pylori pathogenicity. Interactions between H. pylori and bacteria at nongastric sites are likely indirect-via programming of the pro-inflammatory vs. regulatory T lymphocytes-which may have a significant impact on human health.
KW - 16S rDNA
KW - Disease
KW - Helicobacter pylori
KW - Human
KW - Microbial community
KW - Microbiota
KW - Mouse
KW - Rhesus monkey
KW - Stomach
UR - http://www.scopus.com/inward/record.url?scp=84964315606&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84964315606&partnerID=8YFLogxK
U2 - 10.4161/gmic.28573
DO - 10.4161/gmic.28573
M3 - Article
C2 - 24642475
AN - SCOPUS:84964315606
VL - 5
SP - 345
EP - 350
JO - Gut Microbes
JF - Gut Microbes
SN - 1949-0976
IS - 3
ER -