The functional properties of human slow skeletal troponin T isoforms in cardiac muscle regulation

Jose Renato Pinto, Aldrin V Gomes, Michelle A. Jones, Jingsheng Liang, Susan Nguyen, Todd Miller, Michelle S. Parvatiyar, James D. Potter

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

The role of HSSTnT in cardiac muscle regulation is unknown. Results: HSSTnT isoforms regulate Ca2+ sensitivity and maximal force of contraction in skinned fibers in a different fashion compared with HCTnT3. Conclusion: HSSTnT isoforms despite being homologues of CTnT display distinct functional properties. Significance: The HSSTnT isoforms, when expressed in the heart, would play a specific role in desensitizing the myofilament toCa2+.

Original languageEnglish (US)
Pages (from-to)37362-37370
Number of pages9
JournalJournal of Biological Chemistry
Volume287
Issue number44
DOIs
StatePublished - Oct 26 2012

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology

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    Pinto, J. R., Gomes, A. V., Jones, M. A., Liang, J., Nguyen, S., Miller, T., Parvatiyar, M. S., & Potter, J. D. (2012). The functional properties of human slow skeletal troponin T isoforms in cardiac muscle regulation. Journal of Biological Chemistry, 287(44), 37362-37370. https://doi.org/10.1074/jbc.M112.364927