The function of the secondary site of RecA protein during DNA strand exchange

A. V. Mazin, S. C. Kowalczykowski, Andrzej Stasiak

Research output: Contribution to journalArticle

Abstract

Characterization of the concerned action of the primary and secondary DNA binding site of RecA protein and an elucidation of the role of SSB protein in recombination reactions permitted the authors to clarify existing models of homologous recombination (see Fig. 4). In particular, Mazin and Kowalczykowski established that after DNA strand exchange the displaced strand tends to remain in the secondary DNA binding site of RecA filaments unless it is sequestered by SSB protein. By this activity, SSB protein prevents 'reversal' of DNA strand exchange.

Original languageEnglish (US)
Pages (from-to)777-784
Number of pages8
JournalChemtracts
Volume11
Issue number10
StatePublished - Sep 1998
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Medicine

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  • Cite this

    Mazin, A. V., Kowalczykowski, S. C., & Stasiak, A. (1998). The function of the secondary site of RecA protein during DNA strand exchange. Chemtracts, 11(10), 777-784.