The fission yeast stress MAPK cascade regulates the pmp3+ gene that encodes a highly conserved plasma membrane protein

Ling yu Wang, Kazuhiro Shiozaki

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

In eukaryotic organisms, stress-activated mitogen-activated protein kinases (MAPK) play crucial roles in transmitting environmental signals to regulate gene expression for cellular stress adaptation. Here we report that, in the fission yeast Schizosaccharomyces pombe, Spc1/Sty1 MAPK and the Atf1 transcription factor regulate the stress-induced expression of Pmp3, a ubiquitous small membrane protein implicated in the modulation of the plasma membrane potential. The pmp3 null mutant, as well as the spc1 and atf1 mutants, is hypersensitive to the cationic antibiotic hygromycin B. Transcriptional regulation of the Pmp3-like genes by the stress-activated MAPK may also be conserved in other eukaryotes, including plants.

Original languageEnglish (US)
Pages (from-to)2409-2413
Number of pages5
JournalFEBS Letters
Volume580
Issue number10
DOIs
StatePublished - May 1 2006

Fingerprint

Schizosaccharomyces
Cell membranes
Mitogen-Activated Protein Kinases
Yeast
Blood Proteins
Membrane Proteins
Genes
Cell Membrane
Hygromycin B
Eukaryota
Membrane Potentials
Transcription Factors
Gene expression
Anti-Bacterial Agents
Gene Expression
Modulation

Keywords

  • Environmental stress
  • Hygromycin B
  • MAP kinase
  • Plasma membrane
  • Schizosaccharomyces pombe
  • Stress response

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

The fission yeast stress MAPK cascade regulates the pmp3+ gene that encodes a highly conserved plasma membrane protein. / Wang, Ling yu; Shiozaki, Kazuhiro.

In: FEBS Letters, Vol. 580, No. 10, 01.05.2006, p. 2409-2413.

Research output: Contribution to journalArticle

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