The Family Investigation of Nephropathy and Diabetes (FIND): Design and methods

William C. Knowler, Josef Coresh, Robert C. Elston, Barry I. Freedman, Sudha K. Iyengar, Paul L. Kimmel, Jane M. Olson, Rosemarie Plaetke, John R. Sedor, Michael F Seldin

Research output: Contribution to journalArticle

79 Citations (Scopus)

Abstract

Background The Family Investigation of Nephropathy and Diabetes (FIND) is a multicenter study designed to identify genetic determinants of diabetic nephropathy. It is conducted in eight U.S. clinical centers and a coordinating center, and with four ethnic groups (European Americans, African Americans, Mexican Americans, and American Indians). Two strategies are used to localize susceptibility genes: a family-based linkage study and a case-control study using mapping by admixture linkage disequilibrium (MALD). Methods In the family-based study, probands with diabetic nephropathy are recruited with their parents and selected siblings. Linkage analyses will be conducted to identify chromosomal regions containing genes that influence the development of diabetic nephropathy or related quantitative traits such as serum creatinine concentration, urinary albumin excretion, and plasma glucose concentrations. Regions showing evidence of linkage will be examined further with both genetic linkage and association studies to identify genes that influence diabetic nephropathy or related traits. Two types of MALD studies are being done. One is a case-control study of unrelated individuals of Mexican American heritage in which both cases and controls have diabetes, but only the case has nephropathy. The other is a case-control study of African American patients with nephropathy (cases) and their spouses (controls) unaffected by diabetes and nephropathy; offspring are genotyped when available to provide haplotype data. Conclusions Identification of genes that influence susceptibility to diabetic nephropathy will lead to a better understanding of how nephropathy develops. This should eventually lead to improved treatment and prevention.

Original languageEnglish (US)
Pages (from-to)1-9
Number of pages9
JournalJournal of Diabetes and its Complications
Volume19
Issue number1
DOIs
StatePublished - Jan 2005

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Diabetic Nephropathies
Case-Control Studies
Linkage Disequilibrium
African Americans
Genes
Genetic Linkage
North American Indians
Genetic Association Studies
Spouses
Ethnic Groups
Serum Albumin
Haplotypes
Multicenter Studies
Siblings
Creatinine
Parents
Glucose
Serum

Keywords

  • Admixture
  • Diabetes
  • Genetics
  • Linkage
  • Nephropathy

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

The Family Investigation of Nephropathy and Diabetes (FIND) : Design and methods. / Knowler, William C.; Coresh, Josef; Elston, Robert C.; Freedman, Barry I.; Iyengar, Sudha K.; Kimmel, Paul L.; Olson, Jane M.; Plaetke, Rosemarie; Sedor, John R.; Seldin, Michael F.

In: Journal of Diabetes and its Complications, Vol. 19, No. 1, 01.2005, p. 1-9.

Research output: Contribution to journalArticle

Knowler, WC, Coresh, J, Elston, RC, Freedman, BI, Iyengar, SK, Kimmel, PL, Olson, JM, Plaetke, R, Sedor, JR & Seldin, MF 2005, 'The Family Investigation of Nephropathy and Diabetes (FIND): Design and methods', Journal of Diabetes and its Complications, vol. 19, no. 1, pp. 1-9. https://doi.org/10.1016/j.jdiacomp.2003.12.007
Knowler, William C. ; Coresh, Josef ; Elston, Robert C. ; Freedman, Barry I. ; Iyengar, Sudha K. ; Kimmel, Paul L. ; Olson, Jane M. ; Plaetke, Rosemarie ; Sedor, John R. ; Seldin, Michael F. / The Family Investigation of Nephropathy and Diabetes (FIND) : Design and methods. In: Journal of Diabetes and its Complications. 2005 ; Vol. 19, No. 1. pp. 1-9.
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