Abstract
Although there is widespread agreement that the hippocampus is critical for explicit episodic memory retrieval, it is controversial whether this region can also support indirect expressions of relational memory when explicit retrieval fails. Here, using functional magnetic resonance imaging (fMRI) with concurrent indirect, eye-movement-based memory measures, we obtained evidence that hippocampal activity predicted expressions of relational memory in subsequent patterns of viewing, even when explicit, conscious retrieval failed. Additionally, activity in the lateral prefrontal cortex and functional connectivity between the hippocampus and prefrontal cortex were greater for correct than for incorrect trials. Together, these results suggest that hippocampal activity can support the expression of relational memory even when explicit retrieval fails and that recruitment of a broader cortical network may be required to support explicit associative recognition.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 592-599 |
| Number of pages | 8 |
| Journal | Neuron |
| Volume | 63 |
| Issue number | 5 |
| DOIs | |
| State | Published - Sep 10 2009 |
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Keywords
- SYSNEURO
ASJC Scopus subject areas
- Neuroscience(all)
Cite this
The Eyes Have It : Hippocampal Activity Predicts Expression of Memory in Eye Movements. / Hannula, Deborah E.; Ranganath, Charan.
In: Neuron, Vol. 63, No. 5, 10.09.2009, p. 592-599.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The Eyes Have It
T2 - Hippocampal Activity Predicts Expression of Memory in Eye Movements
AU - Hannula, Deborah E.
AU - Ranganath, Charan
PY - 2009/9/10
Y1 - 2009/9/10
N2 - Although there is widespread agreement that the hippocampus is critical for explicit episodic memory retrieval, it is controversial whether this region can also support indirect expressions of relational memory when explicit retrieval fails. Here, using functional magnetic resonance imaging (fMRI) with concurrent indirect, eye-movement-based memory measures, we obtained evidence that hippocampal activity predicted expressions of relational memory in subsequent patterns of viewing, even when explicit, conscious retrieval failed. Additionally, activity in the lateral prefrontal cortex and functional connectivity between the hippocampus and prefrontal cortex were greater for correct than for incorrect trials. Together, these results suggest that hippocampal activity can support the expression of relational memory even when explicit retrieval fails and that recruitment of a broader cortical network may be required to support explicit associative recognition.
AB - Although there is widespread agreement that the hippocampus is critical for explicit episodic memory retrieval, it is controversial whether this region can also support indirect expressions of relational memory when explicit retrieval fails. Here, using functional magnetic resonance imaging (fMRI) with concurrent indirect, eye-movement-based memory measures, we obtained evidence that hippocampal activity predicted expressions of relational memory in subsequent patterns of viewing, even when explicit, conscious retrieval failed. Additionally, activity in the lateral prefrontal cortex and functional connectivity between the hippocampus and prefrontal cortex were greater for correct than for incorrect trials. Together, these results suggest that hippocampal activity can support the expression of relational memory even when explicit retrieval fails and that recruitment of a broader cortical network may be required to support explicit associative recognition.
KW - SYSNEURO
UR - http://www.scopus.com/inward/record.url?scp=69949096619&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=69949096619&partnerID=8YFLogxK
U2 - 10.1016/j.neuron.2009.08.025
DO - 10.1016/j.neuron.2009.08.025
M3 - Article
C2 - 19755103
AN - SCOPUS:69949096619
VL - 63
SP - 592
EP - 599
JO - Neuron
JF - Neuron
SN - 0896-6273
IS - 5
ER -