The Eyes Have It: Hippocampal Activity Predicts Expression of Memory in Eye Movements

Deborah E. Hannula, Charan Ranganath

Research output: Contribution to journalArticle

173 Citations (Scopus)

Abstract

Although there is widespread agreement that the hippocampus is critical for explicit episodic memory retrieval, it is controversial whether this region can also support indirect expressions of relational memory when explicit retrieval fails. Here, using functional magnetic resonance imaging (fMRI) with concurrent indirect, eye-movement-based memory measures, we obtained evidence that hippocampal activity predicted expressions of relational memory in subsequent patterns of viewing, even when explicit, conscious retrieval failed. Additionally, activity in the lateral prefrontal cortex and functional connectivity between the hippocampus and prefrontal cortex were greater for correct than for incorrect trials. Together, these results suggest that hippocampal activity can support the expression of relational memory even when explicit retrieval fails and that recruitment of a broader cortical network may be required to support explicit associative recognition.

Original languageEnglish (US)
Pages (from-to)592-599
Number of pages8
JournalNeuron
Volume63
Issue number5
DOIs
StatePublished - Sep 10 2009

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Eye Movements
Prefrontal Cortex
Hippocampus
Episodic Memory
Magnetic Resonance Imaging

Keywords

  • SYSNEURO

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

The Eyes Have It : Hippocampal Activity Predicts Expression of Memory in Eye Movements. / Hannula, Deborah E.; Ranganath, Charan.

In: Neuron, Vol. 63, No. 5, 10.09.2009, p. 592-599.

Research output: Contribution to journalArticle

Hannula, Deborah E. ; Ranganath, Charan. / The Eyes Have It : Hippocampal Activity Predicts Expression of Memory in Eye Movements. In: Neuron. 2009 ; Vol. 63, No. 5. pp. 592-599.
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