The expression of teneurin-4 in the avian embryo

Richard P Tucker, Doris Martin, Robert Kos, Ruth Chiquet-Ehrismann

Research output: Contribution to journalArticlepeer-review

27 Scopus citations


The teneurins are a family of four transmembrane proteins expressed in the developing vertebrate nervous system, though the Drosophila teneurin ten-m is also a pair-rule gene. Whole-mount in situ hybridization was used to localize teneurin-4 transcripts in the chicken embryo. The earliest signal is detected at stage 19 in the somites and limb buds. By stage 20 teneurin-4 transcripts are detected in temporal periocular mesenchyme, branchial arches, diencephalon and somites. Teneurin-4 expression in the limbs changes dramatically during development. Between stages 19 and 21 teneurin-4 expression is concentrated proximally in the zone of polarizing activity. Between stages 24 and 26 teneurin-4 is expressed in the mesenchyme of the anterodistal part of the limb. As in Drosophila, vertebrate teneurins are expressed not only in the nervous system, but also in non-neuronal tissues during pattern formation. Copyright (C) 2000 Elsevier Science Ireland Ltd.

Original languageEnglish (US)
Pages (from-to)187-191
Number of pages5
JournalMechanisms of Development
Issue number1-2
StatePublished - Nov 1 2000


  • Chick embryo
  • DOC4
  • In situ hybridization
  • Limb development
  • Morphogenesis
  • Neurestin
  • Odz
  • Somite
  • ten-a
  • ten-m
  • Teneurin-1

ASJC Scopus subject areas

  • Developmental Biology
  • Developmental Neuroscience


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