Abstract
The teneurins are a family of four transmembrane proteins expressed in the developing vertebrate nervous system, though the Drosophila teneurin ten-m is also a pair-rule gene. Whole-mount in situ hybridization was used to localize teneurin-4 transcripts in the chicken embryo. The earliest signal is detected at stage 19 in the somites and limb buds. By stage 20 teneurin-4 transcripts are detected in temporal periocular mesenchyme, branchial arches, diencephalon and somites. Teneurin-4 expression in the limbs changes dramatically during development. Between stages 19 and 21 teneurin-4 expression is concentrated proximally in the zone of polarizing activity. Between stages 24 and 26 teneurin-4 is expressed in the mesenchyme of the anterodistal part of the limb. As in Drosophila, vertebrate teneurins are expressed not only in the nervous system, but also in non-neuronal tissues during pattern formation. Copyright (C) 2000 Elsevier Science Ireland Ltd.
Original language | English (US) |
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Pages (from-to) | 187-191 |
Number of pages | 5 |
Journal | Mechanisms of Development |
Volume | 98 |
Issue number | 1-2 |
DOIs | |
State | Published - Nov 1 2000 |
Keywords
- Chick embryo
- DOC4
- In situ hybridization
- Limb development
- Morphogenesis
- Neurestin
- Odz
- Somite
- ten-a
- ten-m
- Teneurin-1
ASJC Scopus subject areas
- Developmental Biology
- Developmental Neuroscience