The expression of tenascin-C and tenascin-W in human ossicles

Richard P Tucker, Cathryn A. Peterson, Ismail Hendaoui, Sandrine Bichet, Ruth Chiquet-Ehrismann

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The ossicles of the middle ear (the malleus, incus and stapes) transmit forces resulting from vibrations of the tympanic membrane to the cochlea where they are coded as sound. Hearing loss can result from diseases such as rheumatoid arthritis (RA) that affect the joints between the ossicles or degenerative processes like otosclerosis that lead to ankylosis of the footplate of the stapes in the oval window of the cochlea. In this study, immunohistochemistry was used to determine if the extracellular matrix glycoproteins tenascin-C or tenascin-W are expressed in the incudomalleolar and incudostapedial joints of ossicles dissected from human cadavers. Tenascin-C, which is expressed during inflammatory conditions including RA, was seen in the articular cartilage of the incudomalleolar joints and the head of the stapes. Tenascin-W, in contrast, was enriched in the annular ligament that anchors the footplate of the stapes into the oval window of the cochlea.

Original languageEnglish (US)
Pages (from-to)416-421
Number of pages6
JournalJournal of Anatomy
Volume229
Issue number3
DOIs
StatePublished - Sep 1 2016

Fingerprint

Stapes
Tenascin
joints (animal)
Cochlea
rheumatoid arthritis
Joints
ankylosis
Rheumatoid Arthritis
hearing
Malleus
Incus
ligaments
anchor
Otosclerosis
vibration
extracellular matrix
Ankylosis
cartilage
Tympanic Membrane
immunohistochemistry

Keywords

  • arthritis
  • extracellular matrix
  • hearing loss
  • ossicle
  • tenascin

ASJC Scopus subject areas

  • Anatomy
  • Ecology, Evolution, Behavior and Systematics
  • Histology
  • Molecular Biology
  • Developmental Biology
  • Cell Biology

Cite this

Tucker, R. P., Peterson, C. A., Hendaoui, I., Bichet, S., & Chiquet-Ehrismann, R. (2016). The expression of tenascin-C and tenascin-W in human ossicles. Journal of Anatomy, 229(3), 416-421. https://doi.org/10.1111/joa.12496

The expression of tenascin-C and tenascin-W in human ossicles. / Tucker, Richard P; Peterson, Cathryn A.; Hendaoui, Ismail; Bichet, Sandrine; Chiquet-Ehrismann, Ruth.

In: Journal of Anatomy, Vol. 229, No. 3, 01.09.2016, p. 416-421.

Research output: Contribution to journalArticle

Tucker, RP, Peterson, CA, Hendaoui, I, Bichet, S & Chiquet-Ehrismann, R 2016, 'The expression of tenascin-C and tenascin-W in human ossicles', Journal of Anatomy, vol. 229, no. 3, pp. 416-421. https://doi.org/10.1111/joa.12496
Tucker RP, Peterson CA, Hendaoui I, Bichet S, Chiquet-Ehrismann R. The expression of tenascin-C and tenascin-W in human ossicles. Journal of Anatomy. 2016 Sep 1;229(3):416-421. https://doi.org/10.1111/joa.12496
Tucker, Richard P ; Peterson, Cathryn A. ; Hendaoui, Ismail ; Bichet, Sandrine ; Chiquet-Ehrismann, Ruth. / The expression of tenascin-C and tenascin-W in human ossicles. In: Journal of Anatomy. 2016 ; Vol. 229, No. 3. pp. 416-421.
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