The expression and function of galectins in skin physiology and pathology

Nan Lin Wu, Fu-Tong Liu

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The galectin family comprises β-galactoside–binding proteins widely expressed in many organisms. There are at least 16 family members, which can be classified into three groups based on their carbohydrate-recognition domains. Pleiotropic functions of different galectins in physiological and pathological processes through extracellular or intracellular actions have been revealed. In the skin, galectins are expressed in a variety of cells, including keratinocytes, melanocytes, fibroblasts, dendritic cells, lymphocytes, macrophages and endothelial cells. Expression of specific galectins is reported to affect cell status, such as activation or death, and regulate the interaction between different cell types or between cells and the extracellular matrix. In vitro cellular studies, in vivo animal studies and studies of human clinical material have revealed the pathophysiologic roles of galectins in the skin. The pathogenesis of diverse non-malignant skin disorders, such as atopic dermatitis, psoriasis, contact dermatitis and wound healing, as well as skin cancers, such as melanoma, squamous cell carcinoma, basal cell carcinoma and cutaneous haematologic malignancy can be regulated by different galectins. Revelation of biological roles of galectins in skin may pave the way to future development of galectin-based therapeutic strategies for skin diseases.

Original languageEnglish (US)
Pages (from-to)217-226
Number of pages10
JournalExperimental Dermatology
Volume27
Issue number3
DOIs
StatePublished - Mar 1 2018

Fingerprint

Skin Physiological Phenomena
Galectins
Physiology
Pathology
Skin
Dermatitis
Physiological Phenomena
Lymphocytes
Macrophages
Melanocytes
Basal Cell Carcinoma
Contact Dermatitis
Endothelial cells
Skin Neoplasms
Hematologic Neoplasms
Pathologic Processes
Atopic Dermatitis
Fibroblasts
Keratinocytes
Psoriasis

Keywords

  • cancer
  • galectin
  • inflammation
  • skin

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Dermatology

Cite this

The expression and function of galectins in skin physiology and pathology. / Wu, Nan Lin; Liu, Fu-Tong.

In: Experimental Dermatology, Vol. 27, No. 3, 01.03.2018, p. 217-226.

Research output: Contribution to journalArticle

Wu, Nan Lin ; Liu, Fu-Tong. / The expression and function of galectins in skin physiology and pathology. In: Experimental Dermatology. 2018 ; Vol. 27, No. 3. pp. 217-226.
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