The exercise pressor reflex and peripheral artery disease

Audrey J. Stone, Marc P Kaufman

Research output: Contribution to journalReview article

17 Scopus citations

Abstract

The exercise pressor reflex contributes to increases in cardiovascular and ventilatory function during exercise. These reflexive increases are caused by both mechanical stimulation and metabolic stimulation of group III and IV afferents with endings in contracting skeletal muscle. Patients with peripheral artery disease (PAD) have an augmented exercise pressor reflex. Recently, an animal model of PAD was established which allows further investigation of possible mechanisms involved in this augmented reflex. Earlier studies have identified ASIC3 channels, bradykinin receptors, P2X receptors, endoperoxide receptors, and thromboxane receptors as playing a role in evoking the exercise pressor reflex in healthy rats. This review focuses on recent studies using a rat model of PAD in order to determine possible mechanisms contributing to the exaggerated exercise pressor reflex seen in patients with this disease.

Original languageEnglish (US)
Pages (from-to)69-73
Number of pages5
JournalAutonomic Neuroscience: Basic and Clinical
Volume188
DOIs
StatePublished - Mar 1 2015
Externally publishedYes

Keywords

  • Autonomic control
  • Claudication
  • Mean arterial pressure
  • Muscle afferents
  • Static contraction

ASJC Scopus subject areas

  • Endocrine and Autonomic Systems
  • Clinical Neurology
  • Cellular and Molecular Neuroscience

Fingerprint Dive into the research topics of 'The exercise pressor reflex and peripheral artery disease'. Together they form a unique fingerprint.

  • Cite this