The ex utero intrapartum treatment (EXIT) procedure

Shinjiro Hirose, Michael R. Harrison

Research output: Contribution to journalReview articlepeer-review

59 Scopus citations


The ex utero intrapartum treatment (EXIT) procedure was originally developed to reverse temporary tracheal occlusion in patients who had undergone foetal surgery for severe congenital diaphragmatic hernia (CDH). In a select group of foetuses with CDH, tracheal occlusion is used to obstruct the normal flow of foetal lung fluid and to stimulate lung expansion and growth. With the airway obstructed, airway management at birth is critical. The solution was to arrange delivery in such a way that the occlusion could be removed and the airway secured while the baby remained on placental support. If the uterus was kept relaxed and the utero-placental blood flow kept intact, the foetus could remain on a maternal 'heart-lung machine' while the airway was secured. While the technique of tracheal occlusion remains under study in clinical trials, EXIT procedures have been shown to be useful for management of other causes of foetal airway obstruction.

Original languageEnglish (US)
Pages (from-to)207-214
Number of pages8
JournalSeminars in Neonatology
Issue number3
StatePublished - Jan 1 2003


  • Airway management
  • Ex utero intrapartum treatment procedure
  • Foetal airway
  • Foetal surgery
  • Neck mass
  • Placental support

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


Dive into the research topics of 'The ex utero intrapartum treatment (EXIT) procedure'. Together they form a unique fingerprint.

Cite this