The evolving science of pharmacogenetics: Clinical and ethnic perspectives

Keh Ming Lin, Russell E. Poland, Yu-Jui Yvonne Wan, Michael W. Smith, Ira M. Lesser

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

The field of pharmacogenetics has witnessed remarkable progress during the past several decades. Clinical observations of severe toxic reactions and findings of dramatic interindividual as well as cross-ethnic differences in response to therapeutic agents have been instrumental in fostering advances of the field. Research on cytochrome P450 isozymes may be of particular importance to the field of psychiatry, because most psychotropics depend on these enzymes for their biotransformation. This article traces the progress of research in this area and highlights the importance of clinical and cross- ethnic observations in providing the impetus and direction for the field. Knowledge derived from this line of research is likely to make important contributions toward establishment of rational guidelines for psychopharmacotherapy. In addition, research on these enzymes may also have profound implications in regard to the pathogenesis of a number of major disorders, including several types of commonly encountered cancers, as well as neuropsychiatric problems, including Parkinson's disease, tardive dyskinesia, addiction, and drug-induced neurotoxicity.

Original languageEnglish (US)
Pages (from-to)205-217
Number of pages13
JournalPsychopharmacology Bulletin
Volume32
Issue number2
StatePublished - 1996

Fingerprint

Pharmacogenetics
Research
Foster Home Care
Poisons
Enzymes
Biotransformation
Cytochrome P-450 Enzyme System
Isoenzymes
Substance-Related Disorders
Parkinson Disease
Psychiatry
Guidelines
Neoplasms
Therapeutics

Keywords

  • ethnicity
  • metabolism
  • P450
  • pharmacogenetics
  • psychotropics

ASJC Scopus subject areas

  • Pharmacology
  • Psychiatry and Mental health

Cite this

Lin, K. M., Poland, R. E., Wan, Y-J. Y., Smith, M. W., & Lesser, I. M. (1996). The evolving science of pharmacogenetics: Clinical and ethnic perspectives. Psychopharmacology Bulletin, 32(2), 205-217.

The evolving science of pharmacogenetics : Clinical and ethnic perspectives. / Lin, Keh Ming; Poland, Russell E.; Wan, Yu-Jui Yvonne; Smith, Michael W.; Lesser, Ira M.

In: Psychopharmacology Bulletin, Vol. 32, No. 2, 1996, p. 205-217.

Research output: Contribution to journalArticle

Lin, KM, Poland, RE, Wan, Y-JY, Smith, MW & Lesser, IM 1996, 'The evolving science of pharmacogenetics: Clinical and ethnic perspectives', Psychopharmacology Bulletin, vol. 32, no. 2, pp. 205-217.
Lin, Keh Ming ; Poland, Russell E. ; Wan, Yu-Jui Yvonne ; Smith, Michael W. ; Lesser, Ira M. / The evolving science of pharmacogenetics : Clinical and ethnic perspectives. In: Psychopharmacology Bulletin. 1996 ; Vol. 32, No. 2. pp. 205-217.
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