The evolving role of C-reactive protein in atherothrombosis

Sridevi Devaraj, Uma Singh, Ishwarlal Jialal

Research output: Contribution to journalArticle

145 Scopus citations

Abstract

Background: Inflammation is pivotal in all phases of atherosclerosis. Among the numerous inflammatory biomarkers, the largest amount of published data supports a role for C-reactive protein (CRP) as a robust and independent risk marker in the prediction of primary and secondary adverse cardiovascular events. In addition to being a risk marker, there is much evidence indicating that CRP may indeed participate in athero-genesis. content: In this review, we focus on the role of CRP in promoting atherothrombosis by discussing its effects on endothelial cells, endothelial progenitor cells, monocyte-macrophages, and smooth muscle cells. conclusions: CRP is clearly a risk marker for cardiovascular disease and is recommended for use in primary prevention. In addition, CRP appears also to contribute to atherogenesis. However, much further research is needed, especially in appropriate animal models, to confirm the possible role of CRP in promoting atherothrombosis.

Original languageEnglish (US)
Pages (from-to)229-238
Number of pages10
JournalClinical Chemistry
Volume55
Issue number2
DOIs
StatePublished - Feb 1 2009

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Biochemistry, medical

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