The evolution of extracellular matrix

Suat Özbek, Prakash G. Balasubramanian, Ruth Chiquet-Ehrismann, Richard P Tucker, Josephine C. Adams

Research output: Contribution to journalArticle

170 Citations (Scopus)

Abstract

We present a perspective on the molecular evolution of the extracellular matrix (ECM) in metazoa that draws on research publications and data from sequenced genomes and expressed sequence tag libraries. ECM components do not function in isolation, and the biological ECM system or "adhesome" also depends on posttranslational processing enzymes, cell surface receptors, and extracellular proteases. We focus principally on the adhesome of internal tissues and discuss its origins at the dawn of the metazoa and the expansion of complexity that occurred in the chordate lineage. The analyses demonstrate very high conservation of a core adhesome that apparently evolved in a major wave of innovation in conjunction with the origin of metazoa. Integrin, CD36, and certain domains predate the metazoa, and some ECM-related proteins are identified in choanoflagellates as predicted sequences. Modern deuterostomes and vertebrates have many novelties and elaborations of ECM as a result of domain shuffling, domain innovations and gene family expansions. Knowledge of the evolution of metazoan ECM is important for understanding how it is built as a system, its roles in normal tissues and disease processes, and has relevance for tissue engineering, the development of artificial organs, and the goals of synthetic biology.

Original languageEnglish (US)
Pages (from-to)4300-4305
Number of pages6
JournalMolecular Biology of the Cell
Volume21
Issue number24
DOIs
StatePublished - Dec 15 2010

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Extracellular Matrix
Choanoflagellata
Synthetic Biology
Chordata
Artificial Organs
Molecular Evolution
Extracellular Matrix Proteins
Expressed Sequence Tags
Cell Surface Receptors
Tissue Engineering
Prednisolone
Integrins
Vertebrates
Publications
Peptide Hydrolases
Genome
Enzymes
Research
Genes

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

Cite this

Özbek, S., Balasubramanian, P. G., Chiquet-Ehrismann, R., Tucker, R. P., & Adams, J. C. (2010). The evolution of extracellular matrix. Molecular Biology of the Cell, 21(24), 4300-4305. https://doi.org/10.1091/mbc.E10-03-0251

The evolution of extracellular matrix. / Özbek, Suat; Balasubramanian, Prakash G.; Chiquet-Ehrismann, Ruth; Tucker, Richard P; Adams, Josephine C.

In: Molecular Biology of the Cell, Vol. 21, No. 24, 15.12.2010, p. 4300-4305.

Research output: Contribution to journalArticle

Özbek, S, Balasubramanian, PG, Chiquet-Ehrismann, R, Tucker, RP & Adams, JC 2010, 'The evolution of extracellular matrix', Molecular Biology of the Cell, vol. 21, no. 24, pp. 4300-4305. https://doi.org/10.1091/mbc.E10-03-0251
Özbek S, Balasubramanian PG, Chiquet-Ehrismann R, Tucker RP, Adams JC. The evolution of extracellular matrix. Molecular Biology of the Cell. 2010 Dec 15;21(24):4300-4305. https://doi.org/10.1091/mbc.E10-03-0251
Özbek, Suat ; Balasubramanian, Prakash G. ; Chiquet-Ehrismann, Ruth ; Tucker, Richard P ; Adams, Josephine C. / The evolution of extracellular matrix. In: Molecular Biology of the Cell. 2010 ; Vol. 21, No. 24. pp. 4300-4305.
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