The evaluation of brain activity in response to taste stimuli - A pilot study and method for central taste activation as assessed by event-related fMRI

Guido K. Frank, Walter H. Kaye, Cameron S Carter, Sarah Brooks, Christopher May, Kate Fissell, V. Andrew Stenger

Research output: Contribution to journalArticle

47 Scopus citations

Abstract

Background: Brain pathways contribute to the regulation of appetite behaviors, and advancements in brain imaging offer new opportunities in determining whether disturbances of these pathways play a role in pathological feeding behaviors in humans. We developed a standardized method for the assessment of brain activation in response to taste stimuli. Methods: Five healthy control women were positioned in a 1.5T GE magnet resonance (MR) scanner for functional MR imaging (fMRI). They received 1.0cm3 samples of 1M glucose solution or artificial saliva (25mM KCl, 2mM NaHCO 3). Fluid challenges were delivered by a programmable syringe pump (J-Kem Scientific, St. Louis, MO). E-Prime software (Psychology Software Tools Inc., Pittsburgh, PA) coordinated taste stimulation with MR scanning. Data were analyzed using NeuroImaging software (NIS). Results: Healthy women showed increased orbitofrontal cortex activation when glucose was compared to artificial saliva. In addition, mesial and lateral temporal cortical regions contrasted glucose from artificial saliva. Conclusions: This study demonstrates a design for the systematic study of brain activation after taste stimulation using fMRI and computer controlled stimulus delivery. The results are consistent with previous studies, showing activation in higher order brain centers that are involved in emotional coding of taste experience.

Original languageEnglish (US)
Pages (from-to)99-105
Number of pages7
JournalJournal of Neuroscience Methods
Volume131
Issue number1-2
DOIs
StatePublished - Dec 30 2003
Externally publishedYes

Keywords

  • Activation
  • Amygdala
  • Functional magnet resonance imaging (fMRI)
  • Orbitofrontal cortex
  • Taste
  • Temporal cortex

ASJC Scopus subject areas

  • Neuroscience(all)

Fingerprint Dive into the research topics of 'The evaluation of brain activity in response to taste stimuli - A pilot study and method for central taste activation as assessed by event-related fMRI'. Together they form a unique fingerprint.

  • Cite this