Abstract
Treatment of prepupae of the cabbage looper, Trichoplusia ni (Hübner), with the anti juvenile hormone (AJH) fluoromevalonolactone (FMev) reduces juvenile hormone esterase (JHE) activity and either delays or inhibits the normal larval-pupal ecdysis in a dose-dependent manner, resulting in the formation of pupae with a suite of characteristic abnormalities. A variety of putative AJHs were evaluated using these teratogenic effects and changes in JHE activity as indicators of AJH activity. Like FMev, the compactin analog L-643,049-01K01 and, at very high doses, 3,3-dichloro-2-propenyl hexanoate (DPH) behaved as AJHs. FMev and L-643,049-01K01 were most effective when larvae were treated at gut purge, while DPH was the most effective after the initiation of spinning behavior.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1011-1016 |
| Number of pages | 6 |
| Journal | Insect Biochemistry |
| Volume | 17 |
| Issue number | 7 |
| DOIs | |
| State | Published - 1987 |
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Keywords
- anti juvenile hormone
- juvenile hormone
- juvenile hormone esterase
- Trichoplusia ni
Cite this
The evaluation of anti juvenile hormones using last stadium larvae of the cabbage looper, Trichoplusia ni (Hübner). / Sparks, Thomas C.; Michael Roe, R.; Buehler, Adrian; Hammock, Bruce D.
In: Insect Biochemistry, Vol. 17, No. 7, 1987, p. 1011-1016.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The evaluation of anti juvenile hormones using last stadium larvae of the cabbage looper, Trichoplusia ni (Hübner)
AU - Sparks, Thomas C.
AU - Michael Roe, R.
AU - Buehler, Adrian
AU - Hammock, Bruce D.
PY - 1987
Y1 - 1987
N2 - Treatment of prepupae of the cabbage looper, Trichoplusia ni (Hübner), with the anti juvenile hormone (AJH) fluoromevalonolactone (FMev) reduces juvenile hormone esterase (JHE) activity and either delays or inhibits the normal larval-pupal ecdysis in a dose-dependent manner, resulting in the formation of pupae with a suite of characteristic abnormalities. A variety of putative AJHs were evaluated using these teratogenic effects and changes in JHE activity as indicators of AJH activity. Like FMev, the compactin analog L-643,049-01K01 and, at very high doses, 3,3-dichloro-2-propenyl hexanoate (DPH) behaved as AJHs. FMev and L-643,049-01K01 were most effective when larvae were treated at gut purge, while DPH was the most effective after the initiation of spinning behavior.
AB - Treatment of prepupae of the cabbage looper, Trichoplusia ni (Hübner), with the anti juvenile hormone (AJH) fluoromevalonolactone (FMev) reduces juvenile hormone esterase (JHE) activity and either delays or inhibits the normal larval-pupal ecdysis in a dose-dependent manner, resulting in the formation of pupae with a suite of characteristic abnormalities. A variety of putative AJHs were evaluated using these teratogenic effects and changes in JHE activity as indicators of AJH activity. Like FMev, the compactin analog L-643,049-01K01 and, at very high doses, 3,3-dichloro-2-propenyl hexanoate (DPH) behaved as AJHs. FMev and L-643,049-01K01 were most effective when larvae were treated at gut purge, while DPH was the most effective after the initiation of spinning behavior.
KW - anti juvenile hormone
KW - juvenile hormone
KW - juvenile hormone esterase
KW - Trichoplusia ni
UR - http://www.scopus.com/inward/record.url?scp=38249038530&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=38249038530&partnerID=8YFLogxK
U2 - 10.1016/0020-1790(87)90112-0
DO - 10.1016/0020-1790(87)90112-0
M3 - Article
AN - SCOPUS:38249038530
VL - 17
SP - 1011
EP - 1016
JO - Insect Biochemistry and Molecular Biology
JF - Insect Biochemistry and Molecular Biology
SN - 0965-1748
IS - 7
ER -