The etiology of transmissible murine colonic hyperplasia

Stephen W Barthold, G. L. Coleman, P. N. Bhatt, G. W. Osbaldiston, A. M. Jonas

Research output: Chapter in Book/Report/Conference proceedingChapter

93 Scopus citations


The etiology of a transmissible colonic mucosal hyperplasia of mice was investigated. Hyperplasia was produced in mice inoculated with unfiltered colonic suspension from affected mice, but infectivity was lost after passage through a 0.45 μm filter. The etiologic agent was subsequently identified as a variant of Citrobacter freundii. The organism induced colonic mucosal hyperplasia when inoculated into germfree mice, and it was recovered in pure culture from the affected animals.

Original languageEnglish (US)
Title of host publicationLaboratory Animal Science
StatePublished - 1976
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)


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