The etiology and pathogenesis of ovine pulmonary carcinoma (sheep pulmonary adenomatosis)

James C. Demartini, Raul H. Rosadio, Michael Dale Lairmore

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Ovine pulmonary carcinoma (OPC, sheep pulmonary adenomatosis, jaagsiekte) occurs naturally as a contagious bronchioloalveolar carcinona of sheep in the Americas, Europe, Africa and Asia. The disease is endemic and economically important in Peru and apparently more common than previously suspected in the U.S.A. The tumor is a result of transformation of type II alveolar epithelial cells or non-ciliated bronchiolar cells of the lung. Clinically affected sheep develop dyspnea, tachypnea and often a watery nasal discharge that originates from tumor secretions. The course is progressive and death usually occurs within a few weeks. To study the viral etiology and pathogenesis of OPC in the U.S.A., the disease was experimentally transmitted to neonatal or young lambs with a success rate of 69%. Ovine lentivirus (OvLV), present in the inocula, was concurrently transmitted and induced lymphoid interstitial pneumonia in most animals. While morphological, immunological and other studies implicate a type D or type B retrovirus as the etiologic agent of OPC, this virus has not yet been cultured and the role of ovine lentivirus in the disease remains unknown.

Original languageEnglish (US)
Pages (from-to)219-236
Number of pages18
JournalVeterinary Microbiology
Volume17
Issue number3
DOIs
StatePublished - 1988
Externally publishedYes

Fingerprint

Ovine Pulmonary Adenomatosis
Pulmonary Adenomatosis
ovine pulmonary adenomatosis
etiology
Sheep
pathogenesis
lungs
sheep
Retroviridae
Lentivirus
neoplasms
dyspnea
Peru
pneumonia
inoculum
epithelial cells
lambs
Alveolar Epithelial Cells
Tachypnea
Endemic Diseases

ASJC Scopus subject areas

  • Animal Science and Zoology
  • Microbiology
  • veterinary(all)

Cite this

The etiology and pathogenesis of ovine pulmonary carcinoma (sheep pulmonary adenomatosis). / Demartini, James C.; Rosadio, Raul H.; Lairmore, Michael Dale.

In: Veterinary Microbiology, Vol. 17, No. 3, 1988, p. 219-236.

Research output: Contribution to journalArticle

@article{15c8df33dc734fd2ace242c8322ff014,
title = "The etiology and pathogenesis of ovine pulmonary carcinoma (sheep pulmonary adenomatosis)",
abstract = "Ovine pulmonary carcinoma (OPC, sheep pulmonary adenomatosis, jaagsiekte) occurs naturally as a contagious bronchioloalveolar carcinona of sheep in the Americas, Europe, Africa and Asia. The disease is endemic and economically important in Peru and apparently more common than previously suspected in the U.S.A. The tumor is a result of transformation of type II alveolar epithelial cells or non-ciliated bronchiolar cells of the lung. Clinically affected sheep develop dyspnea, tachypnea and often a watery nasal discharge that originates from tumor secretions. The course is progressive and death usually occurs within a few weeks. To study the viral etiology and pathogenesis of OPC in the U.S.A., the disease was experimentally transmitted to neonatal or young lambs with a success rate of 69{\%}. Ovine lentivirus (OvLV), present in the inocula, was concurrently transmitted and induced lymphoid interstitial pneumonia in most animals. While morphological, immunological and other studies implicate a type D or type B retrovirus as the etiologic agent of OPC, this virus has not yet been cultured and the role of ovine lentivirus in the disease remains unknown.",
author = "Demartini, {James C.} and Rosadio, {Raul H.} and Lairmore, {Michael Dale}",
year = "1988",
doi = "10.1016/0378-1135(88)90067-3",
language = "English (US)",
volume = "17",
pages = "219--236",
journal = "Veterinary Microbiology",
issn = "0378-1135",
publisher = "Elsevier",
number = "3",

}

TY - JOUR

T1 - The etiology and pathogenesis of ovine pulmonary carcinoma (sheep pulmonary adenomatosis)

AU - Demartini, James C.

AU - Rosadio, Raul H.

AU - Lairmore, Michael Dale

PY - 1988

Y1 - 1988

N2 - Ovine pulmonary carcinoma (OPC, sheep pulmonary adenomatosis, jaagsiekte) occurs naturally as a contagious bronchioloalveolar carcinona of sheep in the Americas, Europe, Africa and Asia. The disease is endemic and economically important in Peru and apparently more common than previously suspected in the U.S.A. The tumor is a result of transformation of type II alveolar epithelial cells or non-ciliated bronchiolar cells of the lung. Clinically affected sheep develop dyspnea, tachypnea and often a watery nasal discharge that originates from tumor secretions. The course is progressive and death usually occurs within a few weeks. To study the viral etiology and pathogenesis of OPC in the U.S.A., the disease was experimentally transmitted to neonatal or young lambs with a success rate of 69%. Ovine lentivirus (OvLV), present in the inocula, was concurrently transmitted and induced lymphoid interstitial pneumonia in most animals. While morphological, immunological and other studies implicate a type D or type B retrovirus as the etiologic agent of OPC, this virus has not yet been cultured and the role of ovine lentivirus in the disease remains unknown.

AB - Ovine pulmonary carcinoma (OPC, sheep pulmonary adenomatosis, jaagsiekte) occurs naturally as a contagious bronchioloalveolar carcinona of sheep in the Americas, Europe, Africa and Asia. The disease is endemic and economically important in Peru and apparently more common than previously suspected in the U.S.A. The tumor is a result of transformation of type II alveolar epithelial cells or non-ciliated bronchiolar cells of the lung. Clinically affected sheep develop dyspnea, tachypnea and often a watery nasal discharge that originates from tumor secretions. The course is progressive and death usually occurs within a few weeks. To study the viral etiology and pathogenesis of OPC in the U.S.A., the disease was experimentally transmitted to neonatal or young lambs with a success rate of 69%. Ovine lentivirus (OvLV), present in the inocula, was concurrently transmitted and induced lymphoid interstitial pneumonia in most animals. While morphological, immunological and other studies implicate a type D or type B retrovirus as the etiologic agent of OPC, this virus has not yet been cultured and the role of ovine lentivirus in the disease remains unknown.

UR - http://www.scopus.com/inward/record.url?scp=0024041164&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024041164&partnerID=8YFLogxK

U2 - 10.1016/0378-1135(88)90067-3

DO - 10.1016/0378-1135(88)90067-3

M3 - Article

VL - 17

SP - 219

EP - 236

JO - Veterinary Microbiology

JF - Veterinary Microbiology

SN - 0378-1135

IS - 3

ER -