The epidemiology of venous thromboembolism

Research output: Contribution to journalArticle

1469 Citations (Scopus)

Abstract

Venous thromboembolism (VTE) occurs for the first time in ≈100 persons per 100,000 each year in the United States, and rises exponentially from <5 cases per 100,000 persons <15 years old to ≈500 cases (0.5%) per 100,000 persons at age 80 years. Approximately one third of patients with symptomatic VTE manifest pulmonary embolism (PE), whereas two thirds manifest deep vein thrombosis (DVT) alone. Despite anticoagulant therapy, VTE recurs frequently in the first few months after the initial event, with a recurrence rate of ≈7% at 6 months. Death occurs in ≈6% of DVT cases and 12% of PE cases within 1 month of diagnosis. The time of year may affect the occurrence of VTE, with a higher incidence in the winter than in the summer. One major risk factor for VTE is ethnicity, with a significantly higher incidence among Caucasians and African Americans than among Hispanic persons and Asian-Pacific Islanders. Overall, ≈25% to 50% of patient with first-time VTE have an idiopathic condition, without a readily identifiable risk factor. Early mortality after VTE is strongly associated with presentation as PE, advanced age, cancer, and underlying cardiovascular disease.

Original languageEnglish (US)
JournalCirculation
Volume107
Issue numberSUPPL. 23
DOIs
StatePublished - Jun 2003

Fingerprint

Venous Thromboembolism
Epidemiology
Pulmonary Embolism
Venous Thrombosis
Incidence
Hispanic Americans
African Americans
Anticoagulants
Cardiovascular Diseases
Recurrence
Mortality
Neoplasms

Keywords

  • Epidemiology
  • Prognosis
  • Pulmonary embolism
  • Thrombosis
  • Veins
  • Venous thromboembolism

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

The epidemiology of venous thromboembolism. / White, Richard H.

In: Circulation, Vol. 107, No. SUPPL. 23, 06.2003.

Research output: Contribution to journalArticle

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