The environment as a driver of immune and endocrine responses in dolphins (Tursiops truncatus)

Patricia A. Fair, Adam M. Schaefer, Dorian S. Houser, Gregory D. Bossart, Tracy A. Romano, Cory D. Champagne, Jeffrey L Stott, Charles D. Rice, Natasha White, John S. Reif

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Immune and endocrine responses play a critical role in allowing animals to adjust to environmental perturbations. We measured immune and endocrine related markers in multiple samples from individuals from two managed-care care dolphin groups (n = 82 samples from 17 dolphins and single samples collected from two wild dolphin populations: Indian River Lagoon, (IRL) FL (n = 26); and Charleston, (CHS) SC (n = 19). The immune systems of wild dolphins were more upregulated than those of managed-care-dolphins as shown by higher concentrations of IgG and increases in lysozyme, NK cell function, pathogen antibody titers and leukocyte cytokine transcript levels. Collectively, managed-care care dolphins had significantly lower levels of transcripts encoding pro-inflammatory cytokine TNF, anti-viral MX1 and INFα and regulatory IL-10. IL-2Rα and CD69, markers of lymphocyte activation, were both lower in managed-care care dolphins. IL-4, a cytokine associated with TH2 activity, was lower in managed-care care dolphins compared to the free-ranging dolphins. Differences in immune parameters appear to reflect the environmental conditions under which these four dolphin populations live which vary widely in temperature, nutrition, veterinary care, pathogen/contaminant exposures, etc. Many of the differences found were consistent with reduced pathogenic antigenic stimulation in managed-care care dolphins compared to wild dolphins. Managed-care care dolphins had relatively low TH2 lymphocyte activity and fewer circulating eosinophils compared to wild dolphins. Both of these immunologic parameters are associated with exposure to helminth parasites which is uncommon in managed-care care dolphins. Less consistent trends were observed in a suite of hormones but significant differences were found for cortisol, ACTH, total T4, free T3, and epinephrine. While the underlying mechanisms are likely multiple and complex, the marked differences observed in the immune and endocrine systems of wild and managed-care care dolphins appear to be shaped by their environment.

Original languageEnglish (US)
Article numbere0176202
JournalPLoS One
Volume12
Issue number5
DOIs
StatePublished - May 1 2017

Fingerprint

Bottle-Nosed Dolphin
Dolphins
Tursiops truncatus
dolphins
Lymphocytes
Pathogens
Cytokines
Managed Care Programs
Immune system
Muramidase
Nutrition
Interleukin-4
Interleukin-10
Adrenocorticotropic Hormone
Epinephrine
Hydrocortisone
Animals
Immunoglobulin G
Rivers
Chemical activation

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Fair, P. A., Schaefer, A. M., Houser, D. S., Bossart, G. D., Romano, T. A., Champagne, C. D., ... Reif, J. S. (2017). The environment as a driver of immune and endocrine responses in dolphins (Tursiops truncatus). PLoS One, 12(5), [e0176202]. https://doi.org/10.1371/journal.pone.0176202

The environment as a driver of immune and endocrine responses in dolphins (Tursiops truncatus). / Fair, Patricia A.; Schaefer, Adam M.; Houser, Dorian S.; Bossart, Gregory D.; Romano, Tracy A.; Champagne, Cory D.; Stott, Jeffrey L; Rice, Charles D.; White, Natasha; Reif, John S.

In: PLoS One, Vol. 12, No. 5, e0176202, 01.05.2017.

Research output: Contribution to journalArticle

Fair, PA, Schaefer, AM, Houser, DS, Bossart, GD, Romano, TA, Champagne, CD, Stott, JL, Rice, CD, White, N & Reif, JS 2017, 'The environment as a driver of immune and endocrine responses in dolphins (Tursiops truncatus)', PLoS One, vol. 12, no. 5, e0176202. https://doi.org/10.1371/journal.pone.0176202
Fair PA, Schaefer AM, Houser DS, Bossart GD, Romano TA, Champagne CD et al. The environment as a driver of immune and endocrine responses in dolphins (Tursiops truncatus). PLoS One. 2017 May 1;12(5). e0176202. https://doi.org/10.1371/journal.pone.0176202
Fair, Patricia A. ; Schaefer, Adam M. ; Houser, Dorian S. ; Bossart, Gregory D. ; Romano, Tracy A. ; Champagne, Cory D. ; Stott, Jeffrey L ; Rice, Charles D. ; White, Natasha ; Reif, John S. / The environment as a driver of immune and endocrine responses in dolphins (Tursiops truncatus). In: PLoS One. 2017 ; Vol. 12, No. 5.
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