The entorhinal cortex of the monkey

III. Subcortical afferents

R. Insausti, David G Amaral, W. M. Cowan

Research output: Contribution to journalArticle

171 Citations (Scopus)

Abstract

The subcortical afferent connections of the entorhinal cortex of the Macaca fascicularis monkey were investigated by the placement of small injections of the retrograde tracer wheat germ agglutinin conjugated to horseradish peroxidase into each of its subdivisions. Retrogradely labeled cells were observed in several subcortical regions including the amygdaloid complex, claustrum, basal forebrain, thalamus, hypothalamus, and brainstem. In the amygdala, labeled cells were observed prinicipally in the lateral nucleus, the accessory basal nucleus, the deep or paralaminar portion of the basal nucleus, and the periamygdaloid cortex. Additional retrogradely labeled cells were found in the endopiriform nucleus, the anterior amygdaloid area, and the cortical nuclei. Retrogradely labeled cells were observed throughout much of the rostrocaudal extent of the claustrum and tended to be located in its ventral half. In the basal forebrain, retrogradely labeled cells were observed in the medial septal nucleus, the nucleus of the diagonal band, and to a lesser extent within the substantia innominata. Several of the cells in the latter region were large and located within the densely packed neuronal clusters of the basal nucleus of Meynert. Most of the labeled cells in the thalamus were located in the midline nuclei. Many were found in nucleus reuniens, but even greater numbers wre located in the centralis complex. Additional labeled cells were located in the paraventricular and parataenial nuclei. In all cases, numerous retrogradely labeled cells were observed in the medial pulvinar. In the hypothalamus, most of the retrogradely labeled cells were located in the supramamillary area, though scattered cells were also observed in the perifornical region and in the lateral hypothalamic area. Caudal to the mamillary nuclei there were labeled cells in the ventral tegmental area. There were relatively few labeled cells in the brainstem and these were invariably located either in the raphe nuclei or locus coeruleus.

Original languageEnglish (US)
Pages (from-to)396-408
Number of pages13
JournalJournal of Comparative Neurology
Volume264
Issue number3
StatePublished - 1987
Externally publishedYes

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Entorhinal Cortex
Haplorhini
Basal Ganglia
Midline Thalamic Nuclei
Septal Nuclei
Thalamus
Hypothalamus
Brain Stem
Substantia Innominata
Pulvinar
Basal Nucleus of Meynert
Lateral Hypothalamic Area
Ventral Tegmental Area
Wheat Germ Agglutinins
Raphe Nuclei
Locus Coeruleus
Macaca fascicularis
Paraventricular Hypothalamic Nucleus
Horseradish Peroxidase
Amygdala

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

The entorhinal cortex of the monkey : III. Subcortical afferents. / Insausti, R.; Amaral, David G; Cowan, W. M.

In: Journal of Comparative Neurology, Vol. 264, No. 3, 1987, p. 396-408.

Research output: Contribution to journalArticle

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